7,12-Dimethylbenz[a]anthracene-DNA adducts in Sprague-Dawley and Long-Evans female rats: the relationship of DNA adducts to mammary cancer

1984 ◽  
Vol 5 (8) ◽  
pp. 1021-1026 ◽  
Author(s):  
F. Bernard Daniel ◽  
Nancy J. Joyce
Keyword(s):  
Dna Adducts ◽  
Mammary Cancer ◽  
Female Rats ◽  
Sprague Dawley ◽  
Long Evans ◽  
Relationship Of ◽  
The Relationship

Further Studies on the Relationship of Adrenal and Gonadal Steroids in Pubertal Development in Female Rats

1979 ◽  
Vol 10 (2-3) ◽  
pp. 130-142 ◽  
Author(s):  
J.R. Ducharme ◽  
A.M. Morera ◽  
P. Laurin ◽  
R. Collu ◽  
L. Audi ◽  
...  
Keyword(s):  
Pubertal Development ◽  
Gonadal Steroids ◽  
Female Rats ◽  
Relationship Of ◽  
The Relationship

Defect in the Renal Tubular Reabsorption of Water Associated With Potassium Depletion in Rats

1957 ◽  
Vol 189 (3) ◽  
pp. 557-563 ◽  
Author(s):  
Walter Hollander ◽  
Robert W. Winters ◽  
T. Franklin Williams ◽  
John Bradley ◽  
Jean Oliver ◽  
...  
Keyword(s):  
Urinary Concentration ◽  
Potassium Depletion ◽  
Sprague Dawley ◽  
Sprague Dawley Rats ◽  
Renal Tubular Reabsorption ◽  
Renal Concentrating Mechanism ◽  
Renal Tubular ◽  
Relationship Of ◽  
The Relationship ◽  
K Depletion

The effect of graded degrees of K depletion on the ability to produce a concentrated urine was studied in Sprague-Dawley rats. With increasing degrees of K depletion, as measured by the concentration of K in fat-free skeletal muscle, there was a progrossive decrease in the maximum urinary concentration. This defect of the renal concentrating mechanism appeared to be better correlated with the degree than with the duration of potassium depletion and could be demonstrated either by the use of exogenous vasopressin or by water deprivation. The potassium-deficient rats in at least one experiment developed a significant polydipsia. The data do not allow any conclusions with respect to the relationship of the polydipsia to the renal concentrating defect except that the latter at least was not severe at the onset of the increased water intake.

Sex Differences in Body-Weight Change following Gonadectomy of Rats

1968 ◽  
Vol 22 (2) ◽  
pp. 547-554 ◽  
Author(s):  
Jan W. Kakolewski ◽  
Verne C. Cox ◽  
Elliot S. Valenstein
Keyword(s):  
Body Weight ◽  
Sex Differences ◽  
Female Rats ◽  
Body Weight Change ◽  
Review Of The Literature ◽  
Male And Female ◽  
Male And Female Rats ◽  
Relationship Of ◽  
The Relationship ◽  
Hypothalamic Damage

Data are presented to demonstrate that the effects of gonadectomy on body weight and food consumption differ in male and female rats. The findings are related to the authors' report of sex differences in the effects of ventromedial hypothalamic damage. A review of the literature on the relationship of the gonads to body weight in different species is presented.

Rem Sleep Deprivation and Pain Thresholds in Rats

1978 ◽  
Vol 47 (3) ◽  
pp. 848-850 ◽  
Author(s):  
Robert A. Hicks ◽  
John D. Moore ◽  
Pamela Findley ◽  
Claire Hirshfield ◽  
Virginia Humphrey
Keyword(s):  
Electrical Stimulation ◽  
Sleep Deprivation ◽  
Rem Sleep ◽  
Pain Threshold ◽  
Female Rats ◽  
Sprague Dawley ◽  
Rem Sleep Deprivation ◽  
Pain Thresholds ◽  
Significant Lowering ◽  
The Relationship

The relationship between REM sleep deprivation and pain threshold was measured using 36 Sprague-Dawley female rats. Relative to that of the controls, a significant lowering of threshold to painful electrical stimulation was observed during each of the post-treatment tests, i.e., immediate, and after 3- and 24-hr. recovery periods, for the animals which had been REM deprived.

MESENTERIC NEUTRAL FAT IN OBESE RATS

1958 ◽  
Vol 36 (1) ◽  
pp. 913-918
Author(s):  
Eldon M. Boyd ◽  
Eleanor M. Crandell
Keyword(s):  
Free Cholesterol ◽  
Dry Weight ◽  
Female Rats ◽  
Albino Rats ◽  
Fat Depots ◽  
Mesenteric Fat ◽  
Obese Rats ◽  
Physiologic Function ◽  
Relationship Of ◽  
The Relationship

The relationship of increasing obesity to storage of neutral fat in the mesentery was investigated in 48 albino rats. Calculated as grams per 100 g nonlipid dry weight, levels of mesenteric neutral fat were positively correlated with levels of mesenteric free cholesterol, phospholipid, and water, the correlation coefficient for water being higher in male than in female rats. These results suggest that storage of neutral fat is an active physiologic function of mesentery. On the other hand, the relative amount of body neutral fat which is stored in the mesentery became less as the animals became more obese. This indicates that in obese rats, some tissue other than mesentery is storing neutral fat at a rate greater than occurs in the mesenteric fat depots.

Pancreatic Hepatocytes Associated with Chronic 2,6-Dichloro-p-Phenylenediamine Administration in Fischer 344 Rats

1989 ◽  
Vol 17 (1_part_1) ◽  
pp. 1-6 ◽  
Author(s):  
Margarita M. McDonald ◽  
Gary A. Boorman
Keyword(s):  
Light Microscopy ◽  
Pancreatic Tissue ◽  
Female Rats ◽  
Fischer 344 Rats ◽  
Fischer 344 ◽  
Relationship Of ◽  
The Relationship ◽  
Pancreatic Hepatocytes

Pancreatic tissue (original and recut sections) from Fischer 344 rats fed 2,6-dichloro-p-phenylenediamine in a chronic (2-year) carcinogenesis bioassay was evaluated for presence of pancreatic hepatocytes (PH) by light microscopy. PH were found in dose groups as follows: males–0 ppm (controls)–0/50 (0%), 1,000 ppm–4/50 (8%), 2,000 ppm–9/50 (18%); females-0 ppm (controls)–1/50 (2%), 2,000 ppm–15/50 (30%), 6,000 ppm–15/49 (31%). This represented a significant dose-related increased incidence of PH in 2,000-ppm males, and 2,000- and 6,000-ppm females. A statistically significant increase ( p < 0.01) in pancreatic acinar atrophy and fibrosis was also seen in treated female rats, but the relationship of these lesions to the PH is unclear.

MESENTERIC NEUTRAL FAT IN OBESE RATS

1958 ◽  
Vol 36 (9) ◽  
pp. 913-918 ◽  
Author(s):  
Eldon M. Boyd ◽  
Eleanor M. Crandell
Keyword(s):  
Free Cholesterol ◽  
Dry Weight ◽  
Female Rats ◽  
Albino Rats ◽  
Fat Depots ◽  
Mesenteric Fat ◽  
Obese Rats ◽  
Physiologic Function ◽  
Relationship Of ◽  
The Relationship

The relationship of increasing obesity to storage of neutral fat in the mesentery was investigated in 48 albino rats. Calculated as grams per 100 g nonlipid dry weight, levels of mesenteric neutral fat were positively correlated with levels of mesenteric free cholesterol, phospholipid, and water, the correlation coefficient for water being higher in male than in female rats. These results suggest that storage of neutral fat is an active physiologic function of mesentery. On the other hand, the relative amount of body neutral fat which is stored in the mesentery became less as the animals became more obese. This indicates that in obese rats, some tissue other than mesentery is storing neutral fat at a rate greater than occurs in the mesenteric fat depots.

Blood Oxygen Capacity of Albino Rats

1956 ◽  
Vol 188 (1) ◽  
pp. 118-120 ◽  
Author(s):  
Jack D. Burke
Keyword(s):  
Body Weight ◽  
Rattus Norvegicus ◽  
Female Rats ◽  
Albino Rats ◽  
Blood Oxygen ◽  
Oxygen Capacity ◽  
Relationship Of ◽  
The Relationship ◽  
Weight Groups

The oxygen capacity of the blood of 64 albino Rattus norvegicus (Sherman strain) was determined by the microgasometric syringe method. Data were obtained showing the relationship of blood oxygen capacity to weight and sex of the animals. It was found that blood oxygen capacity in volumes per cent increased as the weight of the rats increased. Statistically, there was no difference in the blood values in either male or female rats as analyzed in different weight groups and ranges. Also, the oxygen capacity of the blood per unit of body weight decreased as the weight of the rats increased.

THE RELATIONSHIP OF SERUM PHOSPHATASES TO SEX HORMONES

1949 ◽  
Vol 27e (3) ◽  
pp. 202-209 ◽  
Author(s):  
Jules Tuba ◽  
Donald B. Baker ◽  
Max M. Cantor
Keyword(s):  
Serum Alkaline Phosphatase ◽  
Inorganic Phosphorus ◽  
Female Rats ◽  
Male Rats ◽  
Normal Male ◽  
Normal Female ◽  
Hormone Injection ◽  
Relationship Of ◽  
The Relationship ◽  
Phosphorus Levels

Castration produces a fall in serum inorganic phosphorus values in adult male rats but not in adult female rats. The alterations of phosphorus levels that occur following castration in male rats and after the injection of some hormones into normal and castrated rats of both sexes may be accounted for by corresponding alterations in metabolic requirements. Neither castration nor hormone injection produces any significant change in serum acid phosphatase activity in male or in female rats. A fall of about 30% to levels approaching values for normal female rats is found in serum alkaline phosphatase of castrated male rats in about eight weeks. There is no change in the enzyme values in castrated females. In those instances where injections of a sex hormone into castrated or normal rats produce alterations in alkaline serum phosphatase values such changes may be accounted for on the basis of altered food intake. The sole exception to this finding is the very marked decrease in the activity of the enzyme produced by progesterone after oestrogen in normal male rats.

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