scholarly journals Genome-wide gene–environment interaction analysis for asbestos exposure in lung cancer susceptibility

2012 ◽  
Vol 33 (8) ◽  
pp. 1531-1537 ◽  
Author(s):  
Sheng Wei ◽  
Li-E Wang ◽  
Michelle K. McHugh ◽  
Younghun Han ◽  
Momiao Xiong ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cancer Susceptibility ◽  
Interaction Analysis ◽  
Asbestos Exposure ◽  
Environment Interaction ◽  
Gene Environment Interaction ◽  
Gene Environment ◽  
Genome Wide ◽  
Lung Cancer Susceptibility

scholarly journals Haplotype and Haplotype-Environment Interaction Analysis Revealed Roles of SPRY2 for NSCL/P among Chinese Populations

2019 ◽  
Vol 16 (4) ◽  
pp. 557 ◽  
Author(s):  
Ren Zhou ◽  
Mengying Wang ◽  
Wenyong Li ◽  
Siyue Wang ◽  
Hongchen Zheng ◽  
...  
Keyword(s):  
Interaction Analysis ◽  
Genome Wide Association ◽  
Environment Interaction ◽  
Genome Wide Association Studies ◽  
Gene Effects ◽  
Multivitamin Supplementation ◽  
Chinese Populations ◽  
Gene Environment Interaction ◽  
Gene Environment ◽  
Genome Wide

Non-syndromic cleft lip with or without cleft palate (NSCL/P) is one of common birth defects in China, with genetic and environmental components contributing to the etiology. Genome wide association studies (GWASs) have identified SPRY1 and SPRY2 to be associated with NSCL/P among Chinese populations. This study aimed to further explore potential genetic effect and gene—environment interaction among SPRY genes based on haplotype analysis, using 806 Chinese case—parent NSCL/P trios drawn from an international consortium which conducted a genome-wide association study. After the process of quality control, 190 single nucleotide polymorphisms (SNPs) of SPRY genes were included for analyses. Haplotype and haplotype—environment interaction analyses were conducted in Population-Based Association Test (PBAT) software. A 2-SNP haplotype and three 3-SNP haplotypes showed a significant association with the risk of NSCL/P after Bonferroni correction (corrected significance level = 2.6 × 10−4). Moreover, haplotype—environment interaction analysis identified these haplotypes respectively showing statistically significant interactions with maternal multivitamin supplementation or maternal environmental tobacco smoke. This study showed SPRY2 to be associated with NSCL/P among the Chinese population through not only gene effects, but also a gene—environment interaction, highlighting the importance of considering environmental exposures in the genetic etiological study of NSCL/P.

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