scholarly journals One-Carbon Metabolites, B Vitamin Intake, Apolipoprotein E Genotype, and Their Interactive Effects on Cognitive Performance: Secondary Outcomes of the REACH Cohort

2021 ◽  
Vol 5 (Supplement_2) ◽  
pp. 16-16
Author(s):  
Nicola Gillies ◽  
Amber Milan ◽  
David Cameron-Smith ◽  
Cathryn Conlon ◽  
Pamela von Hurst ◽  
...  
Keyword(s):  
Apolipoprotein E ◽  
Cognitive Performance ◽  
Regression Models ◽  
Interactive Effects ◽  
Linear Regression Models ◽  
Vitamin Intake ◽  
Ε4 Allele ◽  
B Vitamin ◽  
Apolipoprotein E Genotype ◽  
Apolipoprotein Ε4

Abstract Objectives To investigate associations between one-carbon metabolites and cognitive performance in older adults, and to examine the interactive effects of B vitamin intake, apolipoprotein E genotype, and one-carbon metabolites on cognition. Methods Three hundred and thirteen healthy older men and women (65–74 years, 65% female) were included in this secondary analysis of the REACH cohort. Cognitive performance was assessed by the Computerised Mental Performance Assessment System (COMPASS). Fasting plasma one-carbon metabolites (betaine, choline, cysteine, dimethylglycine, glycine, homocysteine, methionine, S-adenosylmethionine, serine) were quantified by ultra high performance liquid chromatography with tandem mass spectrometry, and four-day food records were analyzed for nutrient intake. Presence of the apolipoprotein E ε4 allele was measured by polymerase chain reaction amplification. Linear regression models were adjusted for age, sex, batch effects, education level, physical activity, energy intake and supplement use. Interaction terms were fit between continuous (metabolites) and categorical (quartiles of B vitamin intake or metabolites not fit as the main independent variable, presence of apolipoprotein ε4 allele) variables. Results Higher glycine concentrations were associated with better global cognitive performance (β = 1.340, P = 0.017), episodic memory (β = 1.396, P = 0.016) and location learning (β = 1.394, P = 0.027) in linear regression models, although this relationship was not apparent in participants with higher choline concentrations or the apolipoprotein ε4 genotype (interaction, P < 0.05). Conversely, the apolipoprotein ε4 genotype and higher vitamin B12 intake both attenuated the inverse association between Hcy and cognition across several domains of cognitive performance (interaction, P < 0.05). Conclusions The relationship between cognitive performance and one-carbon metabolites, notably glycine and homocysteine, is modified by vitamin B12 intake, apolipoprotein E genotype, and status of inter-connected metabolites. These findings point towards the need for a personalized approach to dietary interventions which protect against age-related cognitive decline. Funding Sources This work was supported by the Health Research Council of New Zealand and AgResearch Ltd.

P-159: Vitamin B12, apolipoprotein E genotype, and cognitive performance

2007 ◽  
Vol 3 (3S_Part_2) ◽  
pp. S149-S149
Author(s):  
Lei Feng ◽  
Tze-Pin NG ◽  
Mathew NITI ◽  
Keng-Bee YAP ◽  
Ee-Heok KUA
Keyword(s):  
Vitamin B12 ◽  
Apolipoprotein E ◽  
Cognitive Performance ◽  
Apolipoprotein E Genotype

scholarly journals Leisure Activities, APOE ε4, and Cognitive Decline: A Longitudinal Cohort Study

2021 ◽  
Vol 13 ◽  
Author(s):  
Yun Zhang ◽  
Shihui Fu ◽  
Ding Ding ◽  
Michael W. Lutz ◽  
Yi Zeng ◽  
...  
Keyword(s):  
Cognitive Decline ◽  
Regression Models ◽  
Mini Mental State Examination ◽  
Leisure Activities ◽  
Interactive Effects ◽  
Logistic Regression Models ◽  
Healthy Longevity ◽  
Productive Activities ◽  
Ε4 Allele ◽  
State Examination

Background: Both leisure activities and the ε4 allele of the apolipoprotein E (APOE ε4) have been shown to affect cognitive health. We aimed to determine whether engagement in leisure activities protects against APOE ε4-related cognitive decline.Methods: We used the cohort data from the Chinese Longitudinal Healthy Longevity Survey. A total of 3,017 participants (mean age of 77.0 years, SD = 9.0; 49.3% female) from 23 provinces of China were recruited in 2008 and were reinterviewed in 2014. We assessed cognitive function using the Mini-Mental State Examination (MMSE). We calculated cognitive decline using subtraction of the MMSE score of each participant in 2008 and 2014. We genotyped a number of APOE ε4 alleles for each participant at baseline and determined the Index of Leisure Activities (ILAs) by summing up the frequency of nine types of typical activities in productive, social, and physical domains. We used ordinal logistic regression models to estimate the effects of leisure activities, APOE ε4, and their interaction on cognitive decline, statistically adjusted for a range of potential confounders.Results: There were significant associations between APOE ε4 and faster cognitive decline, independent of potential confounders, and between leisure activities and mitigated cognitive decline. The odds ratios were 1.25 (95% CI: 1.03, 1.53) and 0.93 (95% CI: 0.89, 0.97), respectively. We found significant interactions of APOE ε4 with leisure activities with a P-value of 0.018. We also observed interactive effects of subtypes of leisure activities: participants who regularly engaged in productive activities were more likely to reduce the risk of APOE ε4-related cognitive decline.Conclusion: Our findings provide support for the indication that participating in leisure activities reduces the risk of APOE ε4-related cognitive decline.

scholarly journals UDSNB 3.0 Neuropsychological Test Norms in Older Adults from a Diverse Community: Results from the Einstein Aging Study (EAS)

2021 ◽  
Vol 83 (4) ◽  
pp. 1665-1678
Author(s):  
Cuiling Wang ◽  
Mindy J. Katz ◽  
Katherine H. Chang ◽  
Jiyue Qin ◽  
Richard B. Lipton ◽  
...  
Keyword(s):  
Cognitive Performance ◽  
Sex Education ◽  
Regression Models ◽  
Normative Data ◽  
First Language ◽  
Linear Regression Models ◽  
Community Based ◽  
Aging Study ◽  
Diverse Community ◽  
Race Ethnicity

Background: The Uniform Data Set, Version 3 Neuropsychological Battery (UDSNB3.0), from the database of the University of Washington’s National Alzheimer’s Coordinating Center (NACC), is widely used to characterize cognitive performance in clinical and research settings; however, norms for underrepresented community-based samples are scarce. Objective: We compared UDSNB 3.0 test scores between the Einstein Aging Study (EAS), composed of racially/ethnically diverse, community-dwelling older adults aged≥70 and the NACC, and report normative data from the EAS. Methods: Analyses included 225 cognitively normal EAS participants and comparable data from 5,031 NACC database participants. Linear regression models compared performance between the samples, adjusting for demographics (sex, age, education, race/ethnicity), depressive symptoms, and whether English was the first language. Linear regression models to examine demographic factors including age, sex, education and race/ethnicity as predictors for the neuropsychological tests were applied in EAS and NACC separately and were used to create a demographically adjusted z-score calculator. Results: Cognitive performance across all domains was worse in the EAS than in the NACC, adjusting for age, sex, education, race/ethnicity, and depression, and the differences remained in visuo-construction, visuospatial memory, confrontation naming, visual attention/processing speed, and executive functioning after further adjusting for whether English was the first language. In both samples, non-Hispanic Whites outperformed non-Hispanic Blacks and more education was associated with better cognitive performance. Conclusion: Differences observed in demographic, clinical, and cognitive characteristics between the community-based EAS sample and the nationwide NACC sample suggest that separate normative data that more accurately reflect non-clinic, community-based populations should be established.

Apolipoprotein E allele polymorphism and ageing: Decreased prevalence of apolipoprotein ε4 allele in old individuals

1995 ◽  
Vol 115 ◽  
pp. S113
Author(s):  
C. Gabelli ◽  
F. Anzolin ◽  
A. Codemo ◽  
G.M. Barbato ◽  
S. Martini ◽  
...  
Keyword(s):  
Apolipoprotein E ◽  
Allele Polymorphism ◽  
Ε4 Allele ◽  
Apolipoprotein Ε4

Cognitive asymmetries associated with apolipoprotein E genotype in patients with Alzheimer's disease

2003 ◽  
Vol 9 (5) ◽  
pp. 751-759 ◽  
Author(s):  
MICHAEL J. FINTON ◽  
JOHN A. LUCAS ◽  
JULIE D. RIPPETH ◽  
DARYL L. BOHAC ◽  
GLENN E. SMITH ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Apolipoprotein E ◽  
Cognitive Performance ◽  
Cognitive Abilities ◽  
Apoe Genotype ◽  
Unique Contribution ◽  
Apoe Ε4 ◽  
Ε4 Allele ◽  
The Relationship

The relationship between apolipoprotein E (apoE) genotype and cognitive performance was examined in 200 patients with probable Alzheimer's disease (AD). Differences between composite measures of verbal and nonverbal functioning were used to define asymmetric patterns of cognition. Patients who were homozygous for apoE ε4 demonstrated relatively worse nonverbal as compared to verbal cognitive ability. In contrast, participants who were heterozygous for apoE ε4 or who possessed no ε4 allele demonstrated relatively equivalent verbal and nonverbal cognitive abilities. Although age and dementia severity also contributed to these patterns, apoE genotype appears to have a significant unique contribution to cognitive performance in these individuals. The ε4 allele may thus be associated with a specific neurocognitive phenotype among patients with AD, with the overall pattern of cognitive asymmetry dependent upon ε4 dose. (JINS, 2003, 9, 751–759.)

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