scholarly journals Pre-referral Rectal Artesunate Treatment by Community-Based Treatment Providers in Ghana, Guinea-Bissau, Tanzania, and Uganda (Study 18): A Cluster-Randomized Trial

2016 ◽  
Vol 63 (suppl 5) ◽  
pp. S312-S321 ◽  
Author(s):  
Marian Warsame ◽  
Margaret Gyapong ◽  
Betty Mpeka ◽  
Amabelia Rodrigues ◽  
Jan Singlovic ◽  
...  
Keyword(s):  
Randomized Trial ◽  
Cluster Randomized Trial ◽  
Community Based ◽  
Treatment Providers ◽  
Guinea Bissau ◽  
Cluster Randomized ◽  
Rectal Artesunate

scholarly journals A Cluster Randomized Trial of a Community-Based Intervention Among African-American Adults: Effects on Dietary and Physical Activity Outcomes

2020 ◽  
Vol 21 (3) ◽  
pp. 344-354
Author(s):  
Leah Frerichs ◽  
Kiana Bess ◽  
Tiffany L. Young ◽  
Stephanie M. Hoover ◽  
Larissa Calancie ◽  
...  
Keyword(s):  
Physical Activity ◽  
African American ◽  
Randomized Trial ◽  
Cluster Randomized Trial ◽  
Community Based ◽  
African American Adults ◽  
Cluster Randomized

1053 Early Combined Immunosuppression for the Management of Crohn's Disease: A Community-Based Cluster Randomized Trial

2014 ◽  
Vol 146 (5) ◽  
pp. S-187 ◽  
Author(s):  
Reena Khanna ◽  
Barrett G. Levesque ◽  
Brian Bressler ◽  
Guangyong Zou ◽  
Larry Stitt ◽  
...  
Keyword(s):  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Randomized Trial ◽  
Cluster Randomized Trial ◽  
Community Based ◽  
Cluster Randomized

scholarly journals Community-Based Accompaniment with Supervised Antiretrovirals for HIV-Positive Adults in Peru: A Cluster-Randomized Trial

2017 ◽  
Vol 22 (1) ◽  
pp. 287-296 ◽  
Author(s):  
Megan M. McLaughlin ◽  
Molly F. Franke ◽  
Maribel Muñoz ◽  
Adrianne K. Nelson ◽  
Olga Saldaña ◽  
...  
Keyword(s):  
Randomized Trial ◽  
Cluster Randomized Trial ◽  
Hiv Positive ◽  
Community Based ◽  
Hiv Positive Adults ◽  
Cluster Randomized

scholarly journals Community Intervention for Child Tuberculosis Active Contact Investigation and Management: Study Protocol for A Cluster Randomized Trial

2020 ◽  
Author(s):  
Anca Vasiliu ◽  
Sabrina Eymard-Duvernay ◽  
Boris Tchounga ◽  
Daniel Atwine ◽  
Elisabete de Carvalho ◽  
...  
Keyword(s):  
Randomized Trial ◽  
Standard Of Care ◽  
Cluster Randomized Trial ◽  
Preventive Therapy ◽  
Community Based ◽  
High Burden ◽  
Eligible Child ◽  
Contact Investigation ◽  
Cluster Randomized ◽  
The Impact

Abstract Background: There are major gaps in the management of pediatric tuberculosis (TB) contact investigation for rapid identification of active tuberculosis and initiation of preventive therapy. This study aims to evaluate the impact of a community-based intervention as compared to facility-based model for the management of children in contact with bacteriologically confirmed pulmonary TB adults in low-resource high-burden settings.Methods/design: This multicenter cluster-randomized trial is composed of three phases: I, baseline phase in which retrospective data are collected, quality of data recording in facility registers is checked and expected acceptability and feasibility of the intervention is assessed; II, intervention phase with enrolment of index cases and contact cases in either facility- or community based models; and III, explanatory phase including endpoint data analysis, cost effectiveness analysis and post-intervention acceptability assessment by heath care providers and beneficiaries. The study uses both quantitative and qualitative analysis methods. The community-based intervention includes identification and screening of all household contacts, referral of contact with TB-suggestive symptoms to the facility for investigation, and household initiation of preventive therapy with follow-up of eligible child contacts by community healthcare workers, i.e. all young (<5 years) child contacts or older (5-14 years) child contacts living with HIV, and with no evidence of TB disease. Twenty clusters representing TB diagnostic and treatment facilities with their catchment areas are randomized in a 1:1 ratio to either the community-based intervention arm or the facility-based standard of care arm in Cameroon and Uganda. The primary endpoint is the proportion of eligible child contacts who initiate and complete the preventive therapy. The sample size is of 1500 child contacts to identify a 10% difference between the arms with the assumption that 60% of children will complete the preventive therapy in the standard of care arm.Discussion: This study will provide evidence of the impact of a community-based intervention on household child contact screening, and management of TB preventive therapy in order to improve care and prevention of childhood TB in high low resource high-burden settings.Trial registration: the study has been registered on the 6th of February 2019 on ClinicalTrials.gov with the number NCT03832023 (https://clinicaltrials.gov/ct2/show/NCT03832023?term=CONTACT&cond=Tuberculosis&cntry=UG&draw=2&rank=1 )

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