PS02.192: TWO CASES OF PRIMARY MALIGNANT MELANOMA OF ESOPHAGUS TREATED WITH SUBTOTAL ESOPHAGECTOMY

Abstract Background Malignant melanoma of the primary esophagus is rare, in general it has high malignancy and poor prognosis. We report two cases of early-stage primary malignant melanoma of esophagus (PMME) underwent subtotal esophagectomy. Methods Case presentation Results [Case 1]A 66-year-old man was pointed out a black legion on the lower esophagus by upper gastrointestinal endoscope for screening purposes. The lesion was diagnosed as malignant melanoma by biopsy. In addition, another black lesion was also found in the pharynx, but there was no malignant cell. Other examinations did not reveal any findings of lymph node metastasis and distant metastasis. We diagnosed PMME (T1aN0M0 Stage 0) and performed surgical resection. Pathologically it was pT1a (LPM), pN0. There is no recurrence, and it is under observation. [Case 2] A 51-year-old woman was conducted upper gastrointestinal endoscopy for the purpose of scarring epigastric pain, and a black lesion was pointed out in lower esophagus. Surgical resection was performed with diagnosis of PMME (T1bN0M0 Stage I). The pathological stage was pT1a (MM), pN0. Conclusion The 5 year survival rate of malignant melanoma of primary esophagus is poor with about 30 to 35%, and especially in cases with lymph node metastasis, the survival rate further decreases. The both cases were discovered accidentally by endoscopic examination, leading to early diagnosis and early treatment. Therefore, long survival is expected. There is also a report that melanosis is associated with melanoma, so case 1 requires careful follow-up observation. Disclosure All authors have declared no conflicts of interest.

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Molecular Diagnosis of the Sentinel Lymph Node Metastasis in Patients with Malignant Melanoma

The Kitakanto Medical Journal ◽

10.2974/kmj.54.209 ◽

2004 ◽

Vol 54 (3) ◽

pp. 209-214

Author(s):

Atsushi Tamura ◽

Yukie Endo ◽

Sachiko Ogino ◽

Yuko Takeuchi ◽

Yayoi Nagai ◽

...

Keyword(s):

Lymph Node ◽

Sentinel Lymph Node ◽

Malignant Melanoma ◽

Lymph Node Metastasis ◽

Molecular Diagnosis ◽

Sentinel Lymph Node Metastasis ◽

Node Metastasis

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Usefulness of 2‐D shear wave elastography for the diagnosis of inguinal lymph node metastasis of malignant melanoma and squamous cell carcinoma

The Journal of Dermatology ◽

10.1111/1346-8138.15545 ◽

2020 ◽

Vol 47 (11) ◽

pp. 1312-1316

Author(s):

Yu Kawahara ◽

Yaei Togawa ◽

Yosuke Yamamoto ◽

Seiichiro Wakabayashi ◽

Hiroyuki Matsue ◽

...

Keyword(s):

Squamous Cell Carcinoma ◽

Lymph Node ◽

Malignant Melanoma ◽

Lymph Node Metastasis ◽

Cell Carcinoma ◽

Shear Wave ◽

Inguinal Lymph Node ◽

Shear Wave Elastography ◽

Inguinal Lymph Node Metastasis ◽

Node Metastasis

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Effects of Concentrated Growth Factor and Cervical Lymph Node Metastasis on the Prognosis of Mucoepidermoid Carcinoma of the Parotid Gland

Nepalese Journal of Cancer ◽

10.3126/njc.v4i1.31775 ◽

2020 ◽

Vol 4 (1) ◽

pp. 45-50

Author(s):

Shang-Zhi Han ◽

Xin Lv ◽

Xi-Bo Chen ◽

Ying-Ying Xu ◽

Rui Liu ◽

...

Keyword(s):

Lymph Node ◽

Survival Rate ◽

Lymph Node Metastasis ◽

Parotid Gland ◽

Distant Metastasis ◽

Mucoepidermoid Carcinoma ◽

Cervical Lymph Node Metastasis ◽

Pathological Grade ◽

Node Metastasis ◽

Independent Risk Factors

Introduction: Mucoepidermoid carcinoma (MEC) is a common salivary gland malignancy. As studies reported on large cases of mucoepidermoid carcinoma of the parotid glands are few, this paper aims to research the effects of clinical and pathological factors, such as applying concentrated growth factor (CGF) on repairing and cervical lymph node metastasis, on the prognosis of mucoepidermoid carcinoma of the parotid gland. Methods: The retrospective analysis of prognostic factors was conducted based on 176 cases with mucoepidermoidcarcinoma of the parotid gland, who received treatment at the Affiliated Hospital of Chengde Medical College during the period of March 2000 to March 2012. Results: The Five-year overall survival rate was 75.57%, while the Five-year tumor-free survival rate was 64.77%. Univariate analysis showed that the influential factors for the prognosis of mucoepidermoid carcinoma of the parotid gland included surgical approach, tumor size, clinical stage, pathological grade, lymph node metastasis, and distant metastasis, etc; among which pathological grade, lymph node metastasis, and distant metastasis were indicated by multivariate analysis to be the independent risk factors. Conclusion: The survival rate of mucoepidermoid carcinoma of the parotid gland is relatively high. Lymph node metastasis, pathological grade, and distant metastasis are the independent risk factors that affect the prognosis of patients with mucous epidermis carcinoma of the parotid gland.

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Clinical Pathological Analysis of Surgically Resected Superficial Esophageal Carcinoma to Determine Criteria for Deciding on Treatment Strategy

Diagnostic and Therapeutic Endoscopy ◽

10.1155/dte.3.211 ◽

1997 ◽

Vol 3 (4) ◽

pp. 211-220 ◽

Cited By ~ 16

Author(s):

H. Makuuchi ◽

H. Shimada ◽

K. Mizutani ◽

O. Chino ◽

T. Nishi ◽

...

Keyword(s):

Lymph Node ◽

Lymph Node Metastasis ◽

Surgical Resection ◽

Lymph Vessel ◽

Depth Of Invasion ◽

Submucosal Cancer ◽

Node Metastasis ◽

Wide Range ◽

Esophageal Carcinomas ◽

Radical Surgical Resection

We performed a clinical pathological study of conventionally resected superficial esophageal carcinomas since this type of lesion has been increasing, in order to develop criteria of determination for therapeutic strategies. Pathological studies were performed on specimens obtained by radical surgical resection in 133 cases of superficial esophageal cancer. Evaluation was performed in terms of the gross classification of the lesion type, depth of invasion, lymph node metastasis, vascular invasion, size of the lesion, outcome, etc. In 0-I, 0-IIc+0-IIa, and 0-III type submucosal cancer lesions the rate of metastasis to lymph nodes was more than 40%, but in 0-IIa and 0-IIb mucosal cancer cases no lymph node metastasis was observed. 0-IIc type lesions showed a wide range of invasiveness, ranging from m1 to sm3. In cases with m1 or m2 invasion, no lymph node or lymph-vessel invasion was recognized, but in m3, sm1, sm2, and sm3 cases lymph node metastasis was recognized in 12.5%, 22.2%, 44.0% and 47.4%, respectively. In 47% of lesions with a greatest dimension of less than 30 mm invasion was limited to the mucosa. Seventy-two percent of m1 and m2 cases were 30 mm in size or less. Lymph node metastasis was recognized in only 16.7% of cases less than 30 mm in size, but in cases of lesions 30 mm or more the rate of lymph node metastasis was 35.8%. 0-IIb and 0-IIa type lesions are indications for endoscopic esophageal mucosal resection (EEMR), while 0-I, 0-IIc+0-IIa, and 0-III lesions should be candidates for radical surgical resection. In the 0-IIc category, lesions in which the depression is relatively flat and with a finely granular surface are indications for EEMR, but those cases in which the surface of depression shows granules of varying sizes should be treated with radical surgical resection. Cases of 0-IIa type 30 mm or larger in greatest dimension which have a gently sloping protruding margin shoulder or reddening should be treated with caution, but EEMR can be performed first and subsequent therapeutic strategy decided on, based on the pathological findings of the specimen.

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