scholarly journals P059. Two new genetic mouse models for ulcerative colitis based on lateral tight junction disruption.

2016 ◽  
Vol 10 (suppl 1) ◽  
pp. S118.1-S118
Keyword(s):  
Ulcerative Colitis ◽  
Tight Junction ◽  
Mouse Models ◽  
Tight Junction Disruption ◽  
Genetic Mouse Models

scholarly journals Genetic Mouse Models with Intestinal-Specific Tight Junction Deletion Resemble an Ulcerative Colitis Phenotype

2017 ◽  
Vol 11 (10) ◽  
pp. 1247-1257 ◽  
Author(s):  
Wolfgang Stremmel ◽  
Simone Staffer ◽  
Mathias Jochen Schneider ◽  
Hongying Gan-Schreier ◽  
Andreas Wannhoff ◽  
...  
Keyword(s):  
Ulcerative Colitis ◽  
Tight Junction ◽  
Mouse Models ◽  
Genetic Mouse Models

Functional genetic mouse models: promising tools for investigation of the proteolytic internet

2009 ◽  
Vol 390 (2) ◽  
pp. 91-97 ◽  
Author(s):  
Achim Krüger
Keyword(s):  
Mouse Models ◽  
Knockout Mice ◽  
Gold Standard ◽  
Disease Susceptibility ◽  
Molecular Polymorphism ◽  
Specific Protease ◽  
Molecular Phenotypes ◽  
The Impact ◽  
Genetic Mouse Models

Abstract Knockout mice are the gold standard to probe for the role of a specific protease within the interacting network of proteases, substrates, and inhibitors. This proteolytic network, or protease web, determines cell signaling and organ homeostasis. Therefore, protease deficiency or inhibition is intrinsically tied to alterations within this network, always leading to new molecular phenotypes, which define susceptibility of an organ to disease. Furthermore, recent hints, mainly from research on matrix metalloproteinases, about the impact of the protease web on inter-organ signaling molecules suggest the existence of a proteolytic internet of communicating local organ- or molecular polymorphism-specific networks, thereby defining homeostasis and disease susceptibility in the whole organism.

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