Short-term mortality risk of serum potassium levels in acute heart failure following myocardial infarction

Introduction: Angiopoietin-like protein 7 (ANGPTL7) is involved in extracellular matrix expression and inflammatory responses. However, the prognostic utility of ANGPTL7 among patients with acute heart failure (AHF) remains unclear. Objective: To evaluate the association between ANGPTL7 and short-term mortality due to AHF. Methods and Results: Patients with AHF were prospectively studied. Serum levels of ANGPTL7 were measured by an enzyme-linked immunosorbent assay. Associations between 30- and 90-day mortality and tertiles of ANGPTL7 were assessed by multivariate logistic regression models. The study comprised 142 patients. Median patient age was 68 years, and 69.7% were male. There were 20 deaths within 30 days and 37 deaths within 90 days. Crude rates of 30-day mortality in low, intermediate, and high tertiles of ANGPTL7 were 4.6, 14.6, and 22.9%, respectively. Crude rates of 90-day mortality of corresponding tertiles were 15.2, 25.0, and 37.5%. After adjusting for potential confounders, including NT-proBNP, the high tertile of ANGPTL7 was associated with a significantly increased risk of both 30-day mortality (odds ratio [OR]: 6.77, 95% confidence interval [CI]: 1.41–32.61, p = 0.017) and 90-day mortality (OR: 3.78, 95% CI: 1.38–10.36, p = 0.010) compared with the low tertile of ANGPTL7. Although mortality risk tended to be higher in the intermediate tertile than the low tertile, it did not reach statistical significance (OR: 3.75, 95% CI: 0.73–19.14, p = 0.113 for 30-day mortality; OR: 1.88, 95% CI: 0.66–5.34, p = 0.236 for 90-day mortality). Conclusions: Serum level of ANGPTL7 was independently associated with short-term mortality among patients with AHF.

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First episode of acute heart failure: Can we already predict the risk of short-term mortality?

European Journal of Internal Medicine ◽

10.1016/j.ejim.2020.04.041 ◽

2020 ◽

Vol 77 ◽

pp. 30-31

Author(s):

Pedro Moliner ◽

Josep Comin-Colet

Keyword(s):

Heart Failure ◽

Acute Heart Failure ◽

First Episode ◽

Short Term ◽

Short Term Mortality

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PROCALCITONIN AS PREDICTOR OF SHORT TERM MORTALITY IN PATIENT WITH ACUTE HEART FAILURE

Journal of the American College of Cardiology ◽

10.1016/s0735-1097(14)60792-0 ◽

2014 ◽

Vol 63 (12) ◽

pp. A792 ◽

Cited By ~ 1

Author(s):

Sun Hee Park ◽

Dong Heon Yang ◽

Jang Hoon Lee ◽

Myung Hwan Bae ◽

Se Yong Jang ◽

...

Keyword(s):

Heart Failure ◽

Acute Heart Failure ◽

Short Term ◽

Short Term Mortality

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Blood lactate is a predictor of short-term mortality in patients with myocardial infarction complicated by heart failure but without cardiogenic shock

BMC Cardiovascular Disorders ◽

10.1186/s12872-018-0744-1 ◽

2018 ◽

Vol 18 (1) ◽

Cited By ~ 5

Author(s):

Grunde Gjesdal ◽

Oscar Ö. Braun ◽

J. Gustav Smith ◽

Fredrik Scherstén ◽

Patrik Tydén

Keyword(s):

Myocardial Infarction ◽

Heart Failure ◽

Cardiogenic Shock ◽

Blood Lactate ◽

Short Term ◽

Short Term Mortality

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Short‐ and Long‐Term Clinical Outcomes for Patients With Takotsubo Syndrome and Patients With Myocardial Infarction: A Report From the Swedish Coronary Angiography and Angioplasty Registry

Journal of the American Heart Association ◽

10.1161/jaha.119.017290 ◽

2021 ◽

Vol 10 (17) ◽

Author(s):

Björn Redfors ◽

Sandeep Jha ◽

Sigurdur Thorleifsson ◽

Tomas Jernberg ◽

Oskar Angerås ◽

...

Keyword(s):

Myocardial Infarction ◽

Heart Failure ◽

Coronary Angiography ◽

Cardiogenic Shock ◽

Acute Heart Failure ◽

Mortality Risk ◽

Takotsubo Syndrome ◽

Killip Class ◽

St Segment Elevation ◽

Similar Risk

Background Takotsubo syndrome (TS) is a potentially life‐threatening acute cardiac syndrome with a clinical presentation similar to myocardial infarction and for which the natural history, management, and outcome remain incompletely understood. Our aim was to assess the relative short‐term mortality risk of TS, ST‐segment–elevation myocardial infarction (STEMI), and non‐STEMI (NSTEMI) and to identify predictors of in‐hospital complications and poor prognosis in patients with TS. Methods and Results This is an observational cohort study based on the data from the SCAAR (Swedish Coronary Angiography and Angioplasty Registry). We included all patients (n=117 720) who underwent coronary angiography in Sweden attributed to TS (N=2898 [2.5%]), STEMI (N=48 493 [41.2%]), or NSTEMI (N=66 329 [56.3%]) between January 2009 and February 2018. We compared patients with TS to those with NSTEMI or STEMI. The primary end point was all‐cause mortality at 30 days. Secondary outcomes were acute heart failure (Killip Class ≥2) and cardiogenic shock (Killip Class 4) at the time of angiography. Patients with TS were more often women compared with patients with STEMI or NSTEMI. TS was associated with unadjusted and adjusted 30‐day mortality risks lower than STEMI (adjusted hazard ratio [adjHR], 0.60; 95% CI, 0.48–0.76; P <0.001), but higher than NSTEMI (adjHR, 2.70; 95% CI, 2.14–3.41; P <0.001). Compared with STEMI, TS was associated with a similar risk of acute heart failure (adjHR, 1.26; 95% CI, 0.91–1.76; P =0.16) but a lower risk of cardiogenic shock (adjHR, 0.55; 95% CI, 0.34–0.89; P =0.02). The relative 30‐day mortality risk for TS versus STEMI and NSTEMI was higher for smokers than nonsmokers (adjusted P interaction STEMI=0.01 and P interaction NSTEMI=0.01). Conclusions The 30‐day mortality rate in TS was higher than in NSTEMI but lower than STEMI despite a similar risk of acute heart failure in TS and STEMI. Among patients with TS, smoking was an independent predictor of mortality.

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