scholarly journals Vascular insights into the treatment of acute myocardial infarction by post-mortem in situ microcomputed tomography and histology

2010 ◽  
Vol 31 (15) ◽  
pp. 1935-1935 ◽  
Author(s):  
Timothy C. Ball ◽  
Jason R. Foerst ◽  
Marc Vorpahl
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Microcomputed Tomography ◽  
Post Mortem

scholarly journals Detection of circRNA Biomarker for Acute Myocardial Infarction Based on System Biological Analysis of RNA Expression

2021 ◽  
Vol 12 ◽  
Author(s):  
Wen Yang ◽  
Li Sun ◽  
Xun Cao ◽  
Luyifei Li ◽  
Xin Zhang ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Coronary Stenosis ◽  
Myocardial Necrosis ◽  
Diagnostic Biomarker ◽  
Blood Samples ◽  
Human Cardiomyocytes ◽  
High Incidence ◽  
High Incidence Rate

Acute myocardial infarction (AMI) is myocardial necrosis caused by the persistent interruption of myocardial blood supply, which has high incidence rate and high mortality in middle-aged and elderly people in the worldwide. Biomarkers play an important role in the early diagnosis and treatment of AMI. Recently, more and more researches confirmed that circRNA may be a potential diagnostic biomarker and therapeutic target for cardiovascular diseases. In this paper, a series of biological analyses were performed to find new effective circRNA biomarkers for AMI. Firstly, the expression levels of circRNAs in blood samples of patients with AMI and those with mild coronary stenosis were compared to reveal circRNAs which were involved in AMI. Then, circRNAs which were significant expressed abnormally in the blood samples of patients with AMI were selected from those circRNAs. Next, a ceRNA network was constructed based on interactions of circRNA, miRNA and mRNA through biological analyses to detect crucial circRNA associated with AMI. Finally, one circRNA was selected as candidate biomarker for AMI. To validate effectivity and efficiency of the candidate biomarker, fluorescence in situ hybridization, hypoxia model of human cardiomyocytes, and knockdown and overexpression analyses were performed on candidate circRNA biomarker. In conclusion, experimental results demonstrated that the candidate circRNA was an effective biomarker for diagnosis and therapy of AMI.

scholarly journals Edema is a sign of early acute myocardial infarction on post-mortem magnetic resonance imaging

2013 ◽  
Vol 9 (4) ◽  
pp. 501-505 ◽  
Author(s):  
Thomas D. Ruder ◽  
Lars C. Ebert ◽  
Ahmed A. Khattab ◽  
Robert Rieben ◽  
Michael J. Thali ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Magnetic Resonance ◽  
Post Mortem ◽  
Resonance Imaging

scholarly journals Cardiac Rupture in Acute Myocardial Infarction: Post-mortem MR Imaging

2011 ◽  
Vol 10 (4) ◽  
pp. 255-258 ◽  
Author(s):  
Yasuyoshi KUROIWA ◽  
Atsushi YAMASHITA ◽  
Kensaku NISHIHIRA ◽  
Yoshisato SHIBATA ◽  
Yunosuke MATSUURA ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Mr Imaging ◽  
Cardiac Rupture ◽  
Post Mortem

scholarly journals CX3CR1 Receptor Polymorphisms, Th1 Cell Recruitment, and Acute Myocardial Infarction Outcome: Looking for a Link

2013 ◽  
Vol 2013 ◽  
pp. 1-9 ◽  
Author(s):  
S. Pucci ◽  
P. Mazzarelli ◽  
M. J. Zonetti ◽  
T. Fisco ◽  
E. Bonanno ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Protective Factor ◽  
Coronary Plaque ◽  
Th1 Cell ◽  
Cell Recruitment ◽  
Fractalkine Receptor ◽  
Infarct Related Artery ◽  
Atherosclerotic Process

Fractalkine is a proinflammatory chemokine that participates in atherosclerotic process mediating the interactions of vascular cells and leukocytes and selective recruitment of Th1 lymphocytes, through interaction with CX3CR1 receptor. The polymorphism of the fractalkine receptor 280M-containing haplotype, which codifies for a receptor with minor expression and with a reduced binding capability, represents a novel protective factor of atherosclerotic disease. We investigated the association among CX3CR1 genotype, the inflammatory infiltrate subpopulations recruited in the plaque, and the in situ expression of fractalkine and its receptor, in patients who died of myocardial infarction (AMI) compared with subjects who died of noncardiac causes. Patients with nonlethal AMI (AMI survivors) were also investigated to correlate the CX3CR1 polymorphisms and the incidence of lethal AMI. A strong T cells infiltrate was found in infarct related artery (IRA) plaques of AMI patients presenting the V249T280haplotype (84%). Conversely, a decreased T cell recruitment was associated with I249T280haplotype in the controls (64%). The significant higher presence of the variant allele I249 in homo- and heterozygosis, found in controls (91%) and in AMI survivors (94%), with respect to the patients who died of AMI (48%), showed the relevance of this polymorphism both in the onset and outcome of acute myocardial infarction. The presence of CX3CR1 polymorphisms could influence the incidence and the outcome of acute myocardial infarction, altering the inflammation of the whole coronary tree by the impaired recruitment of Th1 polarized subpopulation in the coronary plaque.

scholarly journals Acute myocardial infarction in non-cardiac critically ill patients: a clinical-pathological study

2015 ◽  
Vol 74 (4) ◽  
Author(s):  
Giorgio Berlot ◽  
Antonella Vergolini ◽  
Cristina Calderan ◽  
Rossana Bussani ◽  
Lucio Torelli ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Critically Ill ◽  
Critically Ill Patients ◽  
Correct Diagnosis ◽  
Post Mortem ◽  
Post Mortem Examination ◽  
Group 2 ◽  
Clinical Records ◽  
Group 1

Background: in patients admitted to the Intensive Care Unit (ICU) for non cardiac disease, the diagnosis of acute coronary syndromes can be challenging. The aim of the study was to define the rate of discrepancies concerning the diagnosis of acute myocardial infarction and to evaluate the presence of risk factors that could be helpful in identifying patients at higher risk of missed diagnosis. Methods: we compared clinical and autopsy records of 600 critically ill patients who died in our ICU in a 10-years period. We identified patients in whom acute myocardial infarction was reported as the cause of death on the clinical records or was discovered only at post-mortem examination. These subjects were subsequently divided into two Groups: patients in Group 1 underwent diagnostic evaluation for acute myocardial infarction whereas those in Group 2 were not investigated for. Results: In Group 1, a definite clinical diagnosis was reached in 11 patients (14,7%) but remained undetermined in 37 patients (48%). The diagnosis was totally missed in 8 patients in Group 1 (10,6%) and in 20 patients of Group 2 (26,6%). The diagnostic discrepancy was higher in septic patients, in whom the correct diagnosis of acute myocardial infarction was established at a rate lower than 50% in respect to non-septic patients. Conclusions: Our experience strengthens the role of post-mortem examination as a source of feed-back of the overall diagnostic and therapeutic approach especially in septic patients, where the diagnostic error is more frequent.

An electron microscopic study of the intra-myocardial lesions in cases of acute myocardial infarction

1978 ◽  
Vol 36 (2) ◽  
pp. 484-485
Author(s):  
Masahiro Ono ◽  
Kaoru Aihara ◽  
Gompachi Yajima
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Coronary Vessels ◽  
Vascular Wall ◽  
Vascular Changes ◽  
Electron Microscopic ◽  
Main Trunk ◽  
Mechanical Destruction ◽  
Transmission Electron ◽  
Myocardial Lesions

The pathogenesis of the arteriosclerosis in the acute myocardial infarction is the matter of the extensive survey with the transmission electron microscopy in experimental and clinical materials. In the previous communication,the authors have clarified that the two types of the coronary vascular changes could exist. The first category is the case in which we had failed to observe no occlusive changes of the coronary vessels which eventually form the myocardial infarction. The next category is the case in which occlusive -thrombotic changes are observed in which the myocardial infarction will be taken placed as the final event. The authors incline to designate the former category as the non-occlusive-non thrombotic lesions. The most important findings in both cases are the “mechanical destruction of the vascular wall and imbibition of the serous component” which are most frequently observed at the proximal portion of the coronary main trunk.

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