1204Comparison of inpatient mortality trends after acute myocardial infarction between men and women: a 10 year analysis

Introduction: The WHO MONICA Project (Multinational Monitoring of Trends and Determinants in Cardiovascular Disease) was initiated in 1982. The purpose was to evaluate to what extent mortality trends could be explained by changes over time in the population load of conventional cardiovascular risk factors. To test this hypothesis, time trends in cardiovascular event rates have been correlated with trends in levels of risk factors in 35- to 64-year-old men and women in 38 populations. In most MONICA populations, the study has covered a period of 10 years or more. Methods: All acute myocardial infarction and stroke events have been registered in a population-based setting in Norrbotten and Västerbotten counties from 1985 and onwards. The total population is approximately 510,000 inhabitants. In the frame of the WHO MONICA Project, the same strict criteria have been used in all years. Another part of the MONICA Project is population risk factor surveys. In Northern Sweden the first survey took place in 1986 and the following surveys were performed in 1990, 1994, and 1999, including the age group 25 - 74 years (the first two surveys were of the age range 25 - 64 years). Results: From 1985 to 2000, in total 18,105 suspected stroke events, aged 25 - 74 years, were scrutinized and validated at the central stroke office in Northern Sweden. Of these, 13,908 were found to fulfil the MONICA criteria of an acute stroke. During the period 1985 to 1998, in total 13,228 cases of suspected acute myocardial infarction, aged 25 - 64 years, were registered. Of these, 8,744 fulfilled the MONICA criteria for acute myocardial infarction. In the four surveys, in total 9,000 randomly selected men and women were invited for survey. Of these 6,952 (77%) participated in the surveys. Conclusion: From 1985 and onwards, the WHO MONICA project has been going on in Northern Sweden. During the whole time the same strict WHO criteria have been followed.

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Mortality trends in men and women with acute myocardial infarction in coronary care units in Israel. A comparison between 1981–1983 and 1992–1994

European Heart Journal ◽

10.1053/euhj.1999.1868 ◽

2000 ◽

Vol 21 (4) ◽

pp. 284-295 ◽

Cited By ~ 19

Author(s):

S Gottlieb

Keyword(s):

Myocardial Infarction ◽

Acute Myocardial Infarction ◽

Mortality Trends ◽

Men And Women ◽

Coronary Care ◽

Coronary Care Units

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Contemporary Determinants of Delayed Benchmark Timelines in Acute Myocardial Infarction in Men and Women

The American Journal of Cardiology ◽

10.1016/j.amjcard.2017.07.085 ◽

2017 ◽

Vol 120 (10) ◽

pp. 1715-1719 ◽

Cited By ~ 5

Author(s):

Hilmi Alnsasra ◽

Doron Zahger ◽

Diklah Geva ◽

Shlomi Matetzky ◽

Roy Beigel ◽

...

Keyword(s):

Myocardial Infarction ◽

Acute Myocardial Infarction ◽

Men And Women

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Concerning gender and therapy after acute myocardial infarction: are there differences between men and women?

European Heart Journal ◽

10.1053/euhj.1999.1901 ◽

2000 ◽

Vol 21 (4) ◽

pp. 261-262 ◽

Cited By ~ 1

Author(s):

J Alpert

Keyword(s):

Myocardial Infarction ◽

Acute Myocardial Infarction ◽

Men And Women

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Abstract 327: Gender Differences In The Association Between Hemoglobin Change After Acute Myocardial Infarction And Outcomes

Circulation Cardiovascular Quality and Outcomes ◽

10.1161/circoutcomes.6.suppl_1.a327 ◽

2013 ◽

Vol 6 (suppl_1) ◽

Author(s):

Lauren E Thompson ◽

Frederick A Masoudi ◽

Kensey L Gosch ◽

Pamela N Peterson ◽

Adam C Salisbury ◽

...

Keyword(s):

Myocardial Infarction ◽

Acute Myocardial Infarction ◽

Similar Magnitude ◽

Men And Women ◽

Absolute Change ◽

Hospitalization Rates ◽

Lower Baseline ◽

The Relationship ◽

Baseline Hemoglobin

Background: Hemoglobin decline following acute myocardial infarction (AMI) is associated with long-term morbidity. Since women have lower baseline hemoglobin levels than men, whether the same absolute change in hemoglobin after AMI similarly affects outcomes in women and men is unknown. Methods: We examined patients discharged after AMI in the TRIUMPH registry between 2005 and 2008 who had admission and discharge hemoglobin levels. We compared the relationship between absolute change in hemoglobin during hospitalization with 6- and 12-month mortality and re-hospitalization by gender after adjusting for clinical variables including admission hemoglobin. Results: Of the 4,243 patients with AMI, 33% (1,400 of 4,243) were women. Women were older, had more co-morbidities, and were less likely to present with STEMI, or receive catheterization. Women had lower admission hemoglobin (12.9 g/dL ± 1.9 vs 14.5 ± 2.0, p= <0.01) and a smaller mean absolute change in hemoglobin during hospitalization (-1.5 g/dL ± 1.8 vs -1.6 ±1.8, p = 0.01) compared to men. The association between hemoglobin declines during hospitalization and mortality and re-hospitalization rates at 6 and 12-months were of a similar magnitude between men and women (all interaction p > 0.05). (Figure 1) Conclusion: Although women with AMI had lower admission hemoglobin values, similar declines in hemoglobin during hospitalization were associated with increases in mortality and re-hospitalization in women and men. These findings suggest that absolute change in hemoglobin is equally important at predicting outcomes in women and men, regardless of admission hemoglobin levels.

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