scholarly journals Decreased TCF7L2 protein levels in type 2 diabetes mellitus correlate with downregulation of GIP- and GLP-1 receptors and impaired beta-cell function

2009 ◽  
Vol 18 (13) ◽  
pp. 2388-2399 ◽  
Author(s):  
Luan Shu ◽  
Aleksey V. Matveyenko ◽  
Julie Kerr-Conte ◽  
Jae-Hyoung Cho ◽  
Christopher H.S. McIntosh ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Beta Cell ◽  
Beta Cell Function ◽  
Cell Function ◽  
Protein Levels

scholarly journals Decreased TCF7L2 protein levels in type 2 diabetes mellitus correlate with downregulation of GIP- and GLP-1 receptors and impaired beta-cell function

2015 ◽  
Vol 24 (10) ◽  
pp. 3004-3004 ◽  
Author(s):  
L. Shu ◽  
A. V. Matveyenko ◽  
J. Kerr-Conte ◽  
J.-H. Cho ◽  
C. H. S. McIntosh ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Beta Cell ◽  
Beta Cell Function ◽  
Cell Function ◽  
Protein Levels

scholarly journals Diabetic macro- and microvascular disease in type 2 diabetes

2007 ◽  
Vol 4 (2_suppl) ◽  
pp. S7-S11 ◽  
Author(s):  
Michel P Hermans
Keyword(s):  
Diabetes Mellitus ◽  
Insulin Resistance ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Beta Cell ◽  
Beta Cell Function ◽  
Cell Function ◽  
Microvascular Disease ◽  
Patients With Diabetes

Before a patient develops overt type 2 diabetes mellitus, there is typically a prolonged period of patho-physiological change. In the common form of type 2 diabetes mellitus, there are years of insulin resistance, initially compensated by increased beta cell function, then impaired glucose tolerance develops, and finally type 2 diabetes. We know from studies such as the United Kingdom Prospective Diabetes Study (UKPDS) and the Belfast study that loss of beta cell function and insulin resistance are usually relentless.1, 2 Thus, therapy to reduce blood glucose has to be gradually increased with time for patients with diabetes. What is less well known is that every person has a different slope for beta cell function loss which intersects with insulin resistance.

Near-normoglycaemic remission in African-Americans with Type 2 diabetes mellitus is associated with recovery of beta cell function

2001 ◽  
Vol 18 (1) ◽  
pp. 10-16 ◽  
Author(s):  
S. I. McFarlane ◽  
R. L. Chaiken ◽  
S. Hirsch ◽  
P. Harrington ◽  
H. E. Lebovitz ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
African Americans ◽  
Beta Cell ◽  
Beta Cell Function ◽  
Cell Function

Insulin Resistance, Beta Cell Function and Hepatic Steatosis in Youth-onset Type 2 Diabetes Mellitus

2008 ◽  
Vol 32 (4) ◽  
pp. 310
Author(s):  
Kristy Wittmeier ◽  
Samatha Carey ◽  
Joanne Hamilton ◽  
Andrea Macintosh ◽  
Elizabeth Sellers ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Insulin Resistance ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Beta Cell ◽  
Hepatic Steatosis ◽  
Beta Cell Function ◽  
Cell Function ◽  
Onset Type

The Postprandial C-peptide–to–Glucose Ratio Correlated with Beta-Cell Function in Japanese Patients with Type 2 Diabetes Mellitus

Diabetes ◽  
2018 ◽  
Vol 67 (Supplement 1) ◽  
pp. 1831-P
Author(s):  
YUKI MATSUHASHI ◽  
SHINJI CHIKAZAWA ◽  
HIROFUMI NAKAYAMA ◽  
MASAYA MURABAYASHI ◽  
SATORU MIZUSHIRI ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Beta Cell ◽  
Beta Cell Function ◽  
Cell Function ◽  
Japanese Patients ◽  
C Peptide ◽  
Glucose Ratio
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