Defective Polymorphonuclear Leukocyte Chemotaxis in Homosexual Men with Persistent Lymph Node Syndrome

1984 ◽  
Vol 150 (2) ◽  
pp. 267-271 ◽  
Author(s):  
F. H. Valone ◽  
D. G. Payan ◽  
D. I. Abrams ◽  
E. J. Goetzl
1979 ◽  
Vol 21 (1) ◽  
pp. 55-55 ◽  
Author(s):  
Akira Shirahata ◽  
Kaneo Yamada ◽  
Toshio Nojiri ◽  
Yoshikazu Miyaji ◽  
Yukio Iwasaki ◽  
...  

Chemotherapy ◽  
1986 ◽  
Vol 32 (4) ◽  
pp. 379-382 ◽  
Author(s):  
A. Eyraud ◽  
J. Descotes ◽  
J.Y. Lombard ◽  
A. Laschi-Loquerie ◽  
P. Tachon ◽  
...  

1982 ◽  
Vol 5 (10) ◽  
pp. 555-559 ◽  
Author(s):  
T. Takamoto ◽  
A. Niwa ◽  
K. Taniguchi ◽  
J. Takeuchi

Blood ◽  
1985 ◽  
Vol 66 (5) ◽  
pp. 1092-1097
Author(s):  
GS Wood ◽  
CF Garcia ◽  
RF Dorfman ◽  
RA Warnke

Follicle lysis is a characteristic alteration of B cell follicles described recently in lymph node biopsies from homosexual men. It consists of disruption of germinal centers by aggregates of small mature lymphocytes variably associated with erythrocyte extravasation. We studied the immunohistology of follicle lysis identified in lymph node biopsies from 11 homosexual men. The results indicate that follicle lysis has two principal immunohistologic features: (1) intrafollicular aggregates of small lymphocytes predominantly of polytypic mantle B cell phenotype (T015+/Leu-8+/mu+/delta+/k+ or lambda+), and (2) disruption of the normal, unified follicular meshwork of R4/23+ dendritic reticulum cells by these B cell aggregates. These structural alterations may affect the functional integrity of the germinal center as it pertains to the abnormal B cell effector function and the increased prevalence of B cell lymphoma recently documented in the acquired immunodeficiency syndrome and related disorders. Because dendritic reticulum cells weakly express the Leu-3 (T4) antigen, which is known to be an essential component of the receptor for human T- lymphotropic virus type III/lymphadenopathy-associated virus (HTLV- III/LAV) retrovirus infection, it is possible that retroviral infection of dendritic reticulum cells may play a role in the pathogenesis of follicle lysis.


Author(s):  
Karoline Rossi ◽  
Danilo José Silva Moreira ◽  
Juliana Brito da Fonseca ◽  
Suzana dos Santos Vasconcelos ◽  
Vinicius Faustino Lima de Oliveira ◽  
...  

Kawasaki disease (KD) or Mucocutaneous Lymph node Syndrome is a systemic vasculitis, which mainly affects children under five years of age with Asian descent, but can also reach other age groups, as well as any other breed. The clinical picture of KD has three stages: acute febrile stage, in which conjunctival congestion, oral mucositis, erythema, flaking, polymorphic rash and laterocervical lymphadenopathy, appear as main symptoms; the subacute stage, which occurs at the end of fever, and leads to the appearance of skin flaking in the limbs, arthritis, arthralgia and thrombocytosis and finally the stage of convalescence that arises when symptoms are almost dissipating and continues until their normalization. The most used treatment occurs from the administration of intravenous immunoglobulin, which for better prognosis of the pathology should be initiated early.


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