Intercellular adhesion molecule-1 and leukocyte function-associated antigen-1 are involved in protection mediated by CD3+TCRαβ−T cells at the early stage after infection with Listeria monocytogenes in rats

1994 ◽  
Vol 6 (7) ◽  
pp. 955-961 ◽  
Author(s):  
Shin Tomida ◽  
Takashi Hasegawa ◽  
Makoto Takeuchi ◽  
Naoya Nliml ◽  
Minoru Ueda ◽  
...  
Keyword(s):  
T Cells ◽  
Listeria Monocytogenes ◽  
Adhesion Molecule ◽  
Early Stage ◽  
Intercellular Adhesion ◽  
Intercellular Adhesion Molecule ◽  
Intercellular Adhesion Molecule 1 ◽  
Leukocyte Function

scholarly journals Lymphocytic Infiltration and Expression of Intercellular Adhesion Molecule-1 in Photochemically Induced Ischemia of the Rat Cortex

1995 ◽  
Vol 15 (1) ◽  
pp. 42-51 ◽  
Author(s):  
Sebastian Jander ◽  
Matthias Kraemer ◽  
Michael Schroeter ◽  
Otto W. Witte ◽  
Guido Stoll
Keyword(s):  
T Cells ◽  
Adhesion Molecule ◽  
Immune Reaction ◽  
Lymphocytic Infiltration ◽  
Intercellular Adhesion ◽  
Border Zone ◽  
Intercellular Adhesion Molecule ◽  
Intercellular Adhesion Molecule 1 ◽  
Ischemic Lesion ◽  
New Approach

The contribution of the immune system to the pathogenesis of ischemic lesions is still uncertain. We have analyzed leukocyte infiltration in photochemically induced focal ischemia of the rat parietal cortex by immunocytochemistry. Between 1 and 2 days after photothrombosis, CD5 + T cells adhered to subpial and cortical vessels and infiltrated the ischemic lesion prior to macrophages. By day 3 numerous T cells and some macrophages, whose number increased further between day 3 and day 7, had infiltrated the border zone around the lesion sparing the center. In addition, CD5–/CD8+ lymphocytes that probably represent natural killer cells were found. Intercellular adhesion molecule-1 (ICAM-1) was expressed on endothelial cells on days 1 and 2 and in the border zone on infiltrating leukocytes from day 3 to day 7. Starting on day 7, macrophages infiltrated the core of the lesion to remove debris. When the entire lesion was covered by macrophages at day 14, the number of T cells had decreased and ICAM-1 immunoreactivity was no longer found in or around the infarct. In conclusion, our study shows that ischemic lesions can lead to a local immune reaction in the CNS. Thus, blocking of lymphocyte-derived cytokines or cell adhesionmolecules may provide a new approach to confining the sequelae of stroke.

Sign in / Sign up

Export Citation Format

Share Document