Neutral Lipids Rigidify Unsaturated Acyl Chains in Senescing Membranes

1983 ◽  
Vol 34 (3) ◽  
pp. 268-276 ◽  
Author(s):  
R. F. BARBER ◽  
J. E. THOMPSON
Keyword(s):  
Neutral Lipids ◽  
Unsaturated Acyl ◽  
Acyl Chains

scholarly journals Ferroptotic cell death triggered by conjugated linolenic acids is mediated by ACSL1

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Alexander Beatty ◽  
Tanu Singh ◽  
Yulia Y. Tyurina ◽  
Vladimir A. Tyurin ◽  
Svetlana Samovich ◽  
...  
Keyword(s):  
Cell Death ◽  
Therapeutic Potential ◽  
Neutral Lipids ◽  
Cell Types ◽  
Lipid Hydroperoxides ◽  
Conjugated Linolenic Acids ◽  
Cellular Lipids ◽  
Transcriptional Changes ◽  
Acyl Chains ◽  
Tumor Growth And Metastasis

AbstractFerroptosis is associated with lipid hydroperoxides generated by the oxidation of polyunsaturated acyl chains. Lipid hydroperoxides are reduced by glutathione peroxidase 4 (GPX4) and GPX4 inhibitors induce ferroptosis. However, the therapeutic potential of triggering ferroptosis in cancer cells with polyunsaturated fatty acids is unknown. Here, we identify conjugated linoleates including α-eleostearic acid (αESA) as ferroptosis inducers. αESA does not alter GPX4 activity but is incorporated into cellular lipids and promotes lipid peroxidation and cell death in diverse cancer cell types. αESA-triggered death is mediated by acyl-CoA synthetase long-chain isoform 1, which promotes αESA incorporation into neutral lipids including triacylglycerols. Interfering with triacylglycerol biosynthesis suppresses ferroptosis triggered by αESA but not by GPX4 inhibition. Oral administration of tung oil, naturally rich in αESA, to mice limits tumor growth and metastasis with transcriptional changes consistent with ferroptosis. Overall, these findings illuminate a potential approach to ferroptosis, complementary to GPX4 inhibition.

Unsaturated acyl chains dramatically enhanced cellular uptake by direct translocation of a minimalist oligo-arginine lipopeptide

2015 ◽  
Vol 51 (78) ◽  
pp. 14656-14659 ◽  
Author(s):  
J.-M. Swiecicki ◽  
M. Di Pisa ◽  
F. Lippi ◽  
S. Chwetzoff ◽  
C. Mansuy ◽  
...  
Keyword(s):  
Cellular Uptake ◽  
Acyl Chain ◽  
Unsaturated Acyl ◽  
Acyl Chains

Unsaturated acyl chain favours direct translocation of short cationic NBD-labelled peptide.

scholarly journals Gramicidin channels in phospholipid bilayers with unsaturated acyl chains

1997 ◽  
Vol 73 (3) ◽  
pp. 1310-1319 ◽  
Author(s):  
J. Girshman ◽  
D.V. Greathouse ◽  
R.E. Koeppe ◽  
O.S. Andersen
Keyword(s):  
Phospholipid Bilayers ◽  
Unsaturated Acyl ◽  
Acyl Chains

scholarly journals Epilipidomics platform for holistic profiling of oxidized complex lipids in blood plasma of obese individuals

2021 ◽  
Author(s):  
Angela Criscuolo ◽  
Palina Nepachalovich ◽  
Diego Fernando Garcia-del Rio ◽  
Mike Lange ◽  
Zhixu Ni ◽  
...  
Keyword(s):  
Type Ii Diabetes ◽  
Metabolic Disorders ◽  
Neutral Lipids ◽  
Structural Diversity ◽  
Oxidized Lipids ◽  
Lipid Modifications ◽  
Specific Manner ◽  
Acyl Chains ◽  
Complex Lipids ◽  
Regulatory Significance

Lipids are a structurally diverse class of biomolecules which can undergo a variety of chemical modifications. Among them, lipid (per)oxidation attracts most of the attention due to its significance in regulation of inflammation, cell proliferation and death programs. Despite their apparent regulatory significance, the molecular repertoire of oxidized lipids remains largely elusive as accurate annotation of lipid modifications is challenged by their low abundance and largely unknown, biological context-dependent structural diversity. Here we provide a holistic workflow based on the combination of bioinformatics and LC-MS/MS technologies to support identification and relative quantification of oxidized complex lipids in a modification type- and position-specific manner. The developed methodology was used to identify epilipidomics signatures of lean and obese individuals with and without type II diabetes. Characteristic signature of lipid modifications in lean individuals, dominated by the presence of modified octadecanoid acyl chains in phospho- and neutral lipids, was drastically shifted towards lipid peroxidation-driven accumulation of oxidized eicosanoids, suggesting significant alteration of endocrine signalling by oxidized lipids in metabolic disorders.

Anti-tumor-promoting activity of simple models of galactoglycerolipids with branched and unsaturated acyl chains

2005 ◽  
Vol 40 (1) ◽  
pp. 69-74 ◽  
Author(s):  
Diego Colombo ◽  
Laura Franchini ◽  
Lucio Toma ◽  
Fiamma Ronchetti ◽  
Nami Nakabe ◽  
...  
Keyword(s):  
Unsaturated Acyl ◽  
Acyl Chains ◽  
Simple Models
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