scholarly journals Chemical synthesis of a very long oligoribonucleotide with 2-cyanoethoxymethyl (CEM) as the 2′-O-protecting group: structural identification and biological activity of a synthetic 110mer precursor-microRNA candidate

2007 ◽  
Vol 35 (10) ◽  
pp. 3287-3296 ◽  
Author(s):  
Yoshinobu Shiba ◽  
Hirofumi Masuda ◽  
Naoki Watanabe ◽  
Takeshi Ego ◽  
Kazuchika Takagaki ◽  
...  
Keyword(s):  
Biological Activity ◽  
Chemical Synthesis ◽  
Structural Identification ◽  
Protecting Group

Synthesis and Biological Activity Study of Tanshinone Derivatives: A Literature and Patent Review

2020 ◽  
Vol 20 (28) ◽  
pp. 2520-2534
Author(s):  
He Huang ◽  
Chuanjun Song ◽  
Junbiao Chang
Keyword(s):  
Biological Activity ◽  
Herbal Medicine ◽  
Chemical Synthesis ◽  
Bioactive Compounds ◽  
Chinese Herbal Medicine ◽  
Salvia Miltiorrhiza ◽  
Salvia Miltiorrhiza Bunge ◽  
Chinese Herbal ◽  
Patent Review

: Tanshinones are a class of bioactive compounds present in the Chinese herbal medicine Danshen (Salvia miltiorrhiza Bunge), containing among others, abietane diterpene quinone scaffolds. Chemical synthesis and biological activity studies of natural and unnatural tanshinone derivatives have been reviewed in this article.

scholarly journals Enantioselective Catalytic C-H Amidations: An Highlight

Catalysts ◽  
2021 ◽  
Vol 11 (4) ◽  
pp. 471
Author(s):  
Eleonora Tosi ◽  
Renata Marcia de Figueiredo ◽  
Jean-Marc Campagne
Keyword(s):  
Biological Activity ◽  
Chemical Synthesis ◽  
Crucial Role ◽  
Medicinal Chemistry ◽  
Life Sciences ◽  
Biological Processes ◽  
Chiral Molecules ◽  
Material Sciences ◽  
Innovative Approaches

The crucial role played by compounds bearing amide functions, not only in biological processes but also in several fields of chemistry, life polymers and material sciences, has brought about many significant discoveries and innovative approaches for their chemical synthesis. Indeed, a plethora of strategies has been developed to reach such moieties. Amides within chiral molecules are often associated with biological activity especially in life sciences and medicinal chemistry. In most of these cases, their synthesis requires extensive rethinking methodologies. In the very last years (2019–2020), enantioselective C-H functionalization has appeared as a straightforward alternative to reach chiral amides. Therein, an overview on these transformations within this timeframe is going to be given.

scholarly journals Cordycepin analogues of 2-5A and its derivatives. Chemical synthesis and biological activity.

1983 ◽  
Vol 258 (3) ◽  
pp. 1671-1677
Author(s):  
H Sawai ◽  
J Imai ◽  
K Lesiak ◽  
M I Johnston ◽  
P F Torrence
Keyword(s):  
Biological Activity ◽  
Chemical Synthesis

Chemical Synthesis, Structural Modeling, and Biological Activity of the Epidermal Growth Factor-like Domain of HumanCripto

Biochemistry ◽  
1997 ◽  
Vol 36 (13) ◽  
pp. 3837-3845 ◽  
Author(s):  
Matthias Lohmeyer ◽  
Paul M. Harrison ◽  
Subha Kannan ◽  
Marta DeSantis ◽  
Nicola J. O'Reilly ◽  
...  
Keyword(s):  
Biological Activity ◽  
Growth Factor ◽  
Epidermal Growth Factor ◽  
Chemical Synthesis ◽  
Structural Modeling ◽  
Epidermal Growth

Acyl Glucuronides: Biological Activity, Chemical Reactivity, and Chemical Synthesis

ChemInform ◽  
2007 ◽  
Vol 38 (14) ◽  
Author(s):  
Andrew V. Stachulski ◽  
John R. Harding ◽  
John C. Lindon ◽  
James L. Maggs ◽  
B. Kevin Park ◽  
...  
Keyword(s):  
Biological Activity ◽  
Chemical Synthesis ◽  
Chemical Reactivity ◽  
Acyl Glucuronides

scholarly journals Chemical synthesis of the pentasaccharide repeating unit of the O-specific polysaccharide from Escherichia coli O132 in the form of its 2-aminoethyl glycoside

2019 ◽  
Vol 15 ◽  
pp. 2563-2568
Author(s):  
Debasish Pal ◽  
Balaram Mukhopadhyay
Keyword(s):  
Escherichia Coli ◽  
Chemical Synthesis ◽  
Building Blocks ◽  
Protecting Group ◽  
E Coli ◽  
Specific Polysaccharide

The total chemical synthesis of the pentasaccharide repeating unit of the O-polysaccharide from E. coli O132 is accomplished in the form of its 2-aminoethyl glycoside. The 2-aminoethyl glycoside is particularly important as it allows further glycoconjugate formation utilizing the terminal amine without affecting the stereochemistry of the reducing end. The target was achieved through a [3 + 2] strategy where the required monosaccharide building blocks are prepared from commercially available sugars through rational protecting group manipulation. The NIS-mediated activation of thioglycosides was used extensively for the glycosylation reactions throughout.

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