scholarly journals N-acetylcysteine does not prevent hepatorenal ischaemia-reperfusion injury in patients undergoing orthotopic liver transplantation

2010 ◽  
Vol 25 (7) ◽  
pp. 2328-2333 ◽  
Author(s):  
I. A. Hilmi ◽  
Z. Peng ◽  
R. M. Planinsic ◽  
D. Damian ◽  
F. Dai ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Reperfusion Injury ◽  
Orthotopic Liver Transplantation ◽  
Ischaemia Reperfusion Injury ◽  
Ischaemia Reperfusion

Nitric Oxide in Early Ischaemia Reperfusion Injury during Human Orthotopic Liver Transplantation

2004 ◽  
Vol 78 (2) ◽  
pp. 250-256 ◽  
Author(s):  
Raghu Varadarajan ◽  
Lucy Golden-Mason ◽  
Leonie Young ◽  
Paul McLoughlin ◽  
Niamh Nolan ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Liver Transplantation ◽  
Reperfusion Injury ◽  
Orthotopic Liver Transplantation ◽  
Ischaemia Reperfusion Injury ◽  
Ischaemia Reperfusion

scholarly journals Ischaemia–reperfusion injury in liver transplantation—from bench to bedside

2012 ◽  
Vol 10 (2) ◽  
pp. 79-89 ◽  
Author(s):  
Yuan Zhai ◽  
Henrik Petrowsky ◽  
Johnny C. Hong ◽  
Ronald W. Busuttil ◽  
Jerzy W. Kupiec-Weglinski
Keyword(s):  
Liver Transplantation ◽  
Reperfusion Injury ◽  
Ischaemia Reperfusion Injury ◽  
Ischaemia Reperfusion

scholarly journals IL-4 Alleviates Ischaemia-Reperfusion Injury by Inducing Kupffer Cells M2 Polarization via STAT6-JMJD3 Pathway after Rat Liver Transplantation

2020 ◽  
Vol 2020 ◽  
pp. 1-12
Author(s):  
Minghua Deng ◽  
Jingyuan Wang ◽  
Hao Wu ◽  
Menghao Wang ◽  
Ding Cao ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Reperfusion Injury ◽  
Kupffer Cells ◽  
Interleukin 4 ◽  
Ischaemia Reperfusion Injury ◽  
Ischaemia Reperfusion ◽  
M2 Polarization ◽  
Hepatocellular Apoptosis

Background. Liver ischaemia-reperfusion injury (IRI) remains a problem in liver transplantation. Interleukin-4 (IL-4) has been found to reduce liver IRI, but the exact mechanism remains unclear. Methods. Donor livers were infused with recombinant IL-4 or normal saline during cold storage, and the hepatocellular apoptosis and the inflammatory response were detected. The effect of IL-4 treatment on Kupffer cells (KCs) polarization and expression of the STAT6-JMJD3 pathway was evaluated in vivo and in vitro. KCs in donor livers were depleted by clodronate liposome treatment or JMJD3 was inhibited by GSK-J4 before liver transplantation to determine whether the protective effect of IL-4 treatment was dependent on KCs. Results. IL-4 treatment decreased sALT and sAST levels and alleviated hepatocellular apoptosis and inflammation at 6 h after liver transplantation. IL-4 treatment induced KCs alternatively activated (M2) polarization in vitro and in vivo, and the expression of STAT6 and JMJD3 was increased. JMJD3 knockdown abolished KCs M2 polarization and reduced the antiapoptotic and anti-inflammatory effects induced by IL-4 treatment in vitro. In addition, the protection of IL-4 treatment against IRI induced by liver transplantation was significantly reduced after the depletion of KCs or the inhibition of JMJD3 in donor livers. Conclusions. IL-4 treatment-induced KCs M2 polarization was dependent on the STAT6-JMJD3 pathway and protected liver grafts from IRI after liver transplantation.

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