scholarly journals NCMP-01. RISK FACTORS ASSOCIATED WITH LATE HYPERGLYCEMIA IN BRAIN TUMOR PATIENTS WITH POSTOPERATIVE ADMINISTRATION OF DEXAMETHASONE

2019 ◽  
Vol 21 (Supplement_6) ◽  
pp. vi179-vi179
Author(s):  
Seung Ho Yang
Keyword(s):  
Brain Tumor ◽  
Blood Glucose ◽  
Brain Tumors ◽  
Fasting Blood Glucose ◽  
Smoking History ◽  
Diabetic Patients ◽  
Tumor Patients ◽  
Corticosteroid Administration ◽  
Glucose Levels ◽  
Diabetes Patients

Abstract Dexamethasone is the corticosteroid most commonly used for the management of vasogenic edema in patients with brain tumors. The occurrence of hyperglycemia following corticosteroid administration is well known to physicians and health care givers. The purpose of the study is to investigate late onset of hyperglycemia and associated factors in patients with brain tumors. The inclusion criteria are as follows; 1) brain tumor patients underwent craniotomy; 2) steroid administered for at least 3 days longer perioperatively or postoperatively; 3) serum glucose levels examined for at least 3 months postoperatively The exclusion criteria are as follows; 1) steroid administered for less than 3 days; 2) patients diagnosed with type 1 diabetes, renal failure, hepatic failure or autoimmune diseases; 3) other medical illness treated with corticosteroid. A total of 101 patients were enrolled for the analysis. Fasting blood glucose of diabetes patients and non-diabetes patients was 160±93 mg/dl and 114±43 mg/dl, respectively. There was no difference of type of brain tumors, body mass index, hypertension, smoking history, hyperlipidemia, GOT, GPT, ESR, CRP, and Cr between diabetes patients and non-diabetes patients. The peak of Fasting blood glucose was noted on day 1 postoperatively in non-diabetes patients. Two peak of Fasting glucose levels were found on day 1 and 6 postoperatively in diabetes patients. Late hyperglycemia was determined as in patients with fasting blood glucose of >125 mg/dl during 3~6 months postoperatively. Fifteen patients out of 86 non-diabetes patients developed late hyperglycemia. There were significant differences of duration and total dose of dexamethasone administration between late hyperglycemia patients and non-late hyperglycemia patients. Steroid-induced hyperglycemia can develop late postoperatively even in non-diabetic patients with brain tumor treated with dexamethasone. Fasting blood glucose during the first week postoperatively can predict late hyperglycemia. Duration and total dosage of dexamethasone administered are associated with late hyperglycemia.

scholarly journals Frequency of impaired fasting glucose in first degree relatives of Type-II diabetic patients and its association with Body Mass Index

2020 ◽  
Vol 36 (3) ◽  
Author(s):  
Alia Ali Muhammed ◽  
Azeem Taj ◽  
Muhammed Uthman Ahmed ◽  
Elsa Tabrez
Keyword(s):  
Body Mass Index ◽  
Blood Glucose ◽  
Impaired Fasting Glucose ◽  
Type Ii Diabetes ◽  
Fasting Glucose ◽  
Fasting Blood Glucose ◽  
Diabetic Patients ◽  
Type Ii ◽  
Glucose Levels ◽  
First Degree Relatives

Objectives: To determine the frequency of impaired fasting glucose in first degree relatives of people with Type-II diabetes and its association with BMI. Methods: This cross-sectional study was conducted in Diabetic clinic of Shaikh Zayed Hospital, Lahore from July to December 2017. Individuals aged ≥35 years, first degree relatives of people with Type-II diabetes, were selected and their fasting blood glucose levels were checked twice a week apart. Study participants were divided into 3 groups. Group-I were those with normal fasting blood glucose (FBS: <100mg/dl), Group-II were those with impaired fasting glucose (100-125mg/dl), considered as high risk and Group-III included those who turned out to be having frank diabetes (FBS: ≥126mg/dl). Exclusion criteria were known diabetes and pregnancy. Proportions of impaired fasting glucose levels versus BMI were compared using Chi-square test. Significance was considered at P <0.001. Results: A total of hundred subjects were included in the study with the mean age of 44.27 years. Sixty percent participants had normal FBS, 31% showed impaired FBS and 09% had frank diabetes (P <0.001). Significant association was found between impaired fasting glucose and BMI, as with increasing BMI the frequency of impaired fasting glucose increases. Conclusion: First-degree relatives of people with Type-II diabetes showed higher frequency of impaired fasting glucose and obesity was an important risk factor. doi: https://doi.org/10.12669/pjms.36.3.57 How to cite this:Ali A, Taj A, Ahmed MU, Tabrez E. Frequency of impaired fasting glucose in first degree relatives of Type-II diabetic patients and its association with Body Mass Index. Pak J Med Sci. 2020;36(3):407-411. doi: https://doi.org/10.12669/pjms.36.3.57 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

HYPOGLYCEMIC EFFECT OF FLAXSEED LIGNAN AND β GLUCAN IN POSTMENOPAUSAL DIABETIC PATIENTS

2021 ◽  
Vol 5 ◽  
pp. 32-40
Author(s):  
Faiqa Javed
Keyword(s):  
Blood Glucose ◽  
Fasting Blood Glucose ◽  
Diabetic Patients ◽  
Beta Glucan ◽  
Weekly Basis ◽  
Glucose Levels ◽  
Blood Glucose Levels ◽  
Liver And Kidney ◽  
The Subject ◽  
Significant Health

Diabetes mellitus is an important metabolic disorder and owing to its significant health impacts is a leading cause of death around the globe. According to WHO estimates, Pakistan is the 7th highest diabetes affected population of the world where almost 7 million peoples are suffering from the disease. Flaxseed lignan and beta glucan have constructive role in controlling diabetes. In connection to their enhanced insulin sensitivity, dietary supplementation of flaxseed fiber has shown potential results in postmenopausal diabetic women. The subject population was feed with lignan and beta glucan capsules and hypoglycemic activity was monitored both on daily and weekly basis. Blood samples was taken to observe the blood glucose by use of flaxseed lignan and β glucan in postmenopausal women. Fasting and random glucose levels of postmenopausal diabetic women in 4 weeks fed on flaxseed lignan and β glucan (P<0.01). Liver and kidney functioning tests are found to be non-significant. This research indicates that flaxseed lignan and β glucan reduces the random and fasting blood glucose levels in postmenopausal patients.

scholarly journals Mean platelet volume: An economical diagnostic marker of cardiovascular risk assessment in altered fasting blood glucose levels

2015 ◽  
Vol 7 (1) ◽  
pp. 30-33
Author(s):  
Shivali Kapoor ◽  
Manjit Kaur ◽  
Amrit Pal Singh Rana ◽  
A Suryanarayan
Keyword(s):  
Blood Glucose ◽  
Mean Platelet Volume ◽  
Fasting Blood Glucose ◽  
Progressive Increase ◽  
Diabetic Patients ◽  
Platelet Volume ◽  
Glucose Levels ◽  
Blood Glucose Levels ◽  
Group I ◽  
Increased Risk

Background: Platelets with altered morphology or large size are more thrombogenic and are likely to be associated with increased risk of vascular disease. Platelet parameters especially high mean platelet volume (MPV) has been reported in diabetic patients as major contributing factor. The aim of the present study was to find correlation between fasting blood glucose value and hematological variables (PC and MPV), not only in diabetics, but also in the normoglycemic subjects and patients with impaired fasting blood glucose levels.Materials and Methods: In the present study 3471 subjects were analyzed retrospectively and categorized into three groups based on the fasting blood glucose levels as Group I - normoglycemics (FBG ? 109 mg/dl, n = 1158), Group II- impaired fasting blood glucose (FBG ? 126 mg/dl, n = 1158) and Group III – Diabetics (FBG ? 127 mg/dl, n = 1155).Results: We found progressive increase in value of MPV with the increasing FBG levels, in the following order: G1 (8.44 ± 0.842 fl), G2 (8.98 ± 0.898 fl), G3 (9.31 ± 0.967 fl). The platelet count however, did not show much statistical significance with rising glucose levels.Conclusions: MPV increased proportionally with increasing plasma glucose levels. Although the variation between the normoglycemics and impaired fasting group was not very significant, the parameters still showed progressive increase with rising sugar levels significant in diabetic group.Asian Journal of Medical Sciences Vol.7(1) 2015 30-33

scholarly journals Comparison of Frequency Distribution of Diabetes in Hepatitis B and C Patients and Other People in Birjand

2021 ◽  
Vol 18 (1) ◽  
Author(s):  
Masood Ziaee ◽  
Mahboube Saljoughi ◽  
Forough Fardinfar ◽  
Farah Madarshahian ◽  
Azadeh  Ebrahimzadeh
Keyword(s):  
Blood Glucose ◽  
Hepatitis C ◽  
Hepatitis B ◽  
Frequency Distribution ◽  
Statistical Tests ◽  
Fasting Blood Glucose ◽  
Diabetic Patients ◽  
Retrospective Case ◽  
Glucose Levels ◽  
Significant Difference

Background: Diabetes and hepatitis are among the most common diseases in the world. Hepatitis C virus leads to extra-liver manifestations, including endocrine disease and diabetes. The prevalence of hepatitis C and B in diabetic patients and the prevalence of diabetes in hepatitis C and B patients are higher than those in normal populations, and if each is added to the other, the complications will be more and the consequences will be worse. Objectives: This study aimed to compare the frequency distribution of diabetes and serum lipid levels in hepatitis B and C patients and other people. Methods: In this retrospective case-control study, 80 patients with hepatitis B and C and 160 patients without hepatitis were included. In both groups, those with two glucose levels above 126 mg/dL were considered as diabetic subjects. Also, the tests for factors such as cholesterol, TG, LDL, HbA1c, HDL, and liver ultrasonography were performed for patients. Data were collected and entered into SPSS 23 software and analyzed using descriptive statistical tests (t test and chi-square or Fisher's exact test) at a significance level of α = 0.05. Results: A total of 240 patients [80 cases (hepatitis B or C positive) and 160 controls] were enrolled. Of them, 46.3% were females and most of them were in the age range of 45-55 years. Besides, 14 (5.8%) subjects had high fasting blood glucose levels of more than 126 mg/dl twice, and were considered to have diabetes. Among them, four (5.0%) cases (all having hepatitis B) and 10 (6.3%) controls were diabetics. Statistical analysis showed no significant difference in the mean serum lipids of cholesterol and LDL between the case and control groups (P < 0.1) but there was a significant association between HDL and TG in both groups (P = 0.02). Conclusions: All patients with hepatitis B and C should be screened for diabetes, and in addition to fasting blood glucose, we suggest that HbA1c be measured to confirm or rule out diabetes.

scholarly journals Assessment of the salivary glucose as a non-invasive test for diabetic patients

2019 ◽  
Vol 6 (6) ◽  
pp. 2289
Author(s):  
Kajol Thapa ◽  
Saroj Kunwar ◽  
Sonu Thapa ◽  
Asmita Phuyal ◽  
Sahil Rupakheti
Keyword(s):  
Diabetes Mellitus ◽  
Blood Glucose ◽  
Glucose Level ◽  
Fasting Blood Glucose ◽  
Diabetic Patients ◽  
Glucose Levels ◽  
Non Invasive ◽  
Invasive Test ◽  
Blood Glucose Levels ◽  
Institutional Review

Background: Over the recent year there has been a startling rise in the number of people suffering from diabetes mellitus. Estimation of blood glucose levels has been an essential laboratory investigation for screening and monitoring of diabetes. Saliva is one of the secretions in human body whose collection is easy and non-invasive. Salivary glucose hence could serve as an easy and non-invasive tool.Methods: Institutional review committee of NHRC gave us permission to carry out this study. 105 subjects with Type 2 diabetes mellitus who attended the OPD at Star hospital, Sanepa, Lalitpur, Nepal and 106 healthy individuals were consented to participate in this study. Glucose was measured by the GOD-POD (Glucose oxidase peroxidase) methods using the semi-autoanalyser and salivary glucose was compared with corresponding blood glucose levels.Results: A significant positive correlation of fasting salivary glucose level and fasting blood glucose level was observed in healthy (r=0.241, p=0.001) and in diabetic patients (r=0.202, p=0.001).Conclusions: The study implies a potential for saliva in monitoring and screening of diabetes mellitus.

scholarly journals Effect of ranolazine on HbA1c and blood glucose levels in diabetic patients with chronic angina

2019 ◽  
Vol 8 (3) ◽  
pp. 377
Author(s):  
Shilpa B. N. ◽  
Shashikala G. H. ◽  
Siddesh . ◽  
Mallesh P.
Keyword(s):  
Blood Glucose ◽  
Fasting Blood Glucose ◽  
Preventive Therapy ◽  
Antidiabetic Drugs ◽  
Diabetic Patients ◽  
Glucose Levels ◽  
Blood Glucose Levels ◽  
Patients With Diabetes ◽  
Chronic Angina ◽  
Group 2

Background: Diabetes mellitus is the fifth leading cause of death worldwide and is one of the common co-morbid conditions associated with coronary artery disease (CAD). The overall prevalence of CAD is 7.4% but the prevalence of CAD in diabetics is 9%. Hence treatment of hyperglycemia is a key goal of secondary preventive therapy with a target of reducing HbA1c to <7%. The risk of CAD has been reported to occur 2 to3 decades prior in diabetics compared to non-diabetics. Hence discovery of drugs with potential role in both diabetes and CAD seems to be necessary. Ranolazine is a novel oral anti anginal drug known to reduce HbA1c and fasting blood glucose levels in angina patients with diabetes. The objective of this study is to show the effect of ranolazine (antianginal drug) on HbA1c and fasting blood glucose levels in diabetic patients with chronic angina.Methods: Patients were divided into: Group 1 continued with previous antidiabetic drugs and antianginal drugs. Group 2 were prescribed Tab ranolazine 1000mg b.d (orally) as add on therapy along with previous antidiabetic drugs and antianginal drugs.Results: There was a significant reduction in HbA1c and FBS levels in Group 2 patients who were on ranolazine. Reduction of HbA1c in group1 and Group 2 was 0.21±0.65% and 1.30±1.16% respectively. Reduction of FBS in group1 and group2 was 10.66±27.80mg/dl and 29.97±31.49mg/dl respectively.Conclusions: From the present study we can conclude that ranolazine, an antianginal drug when given at a dose of 1000mg bd in diabetic patients with chronic angina reduces HbA1c and FBS levels. 

scholarly journals Family Medical History (Knowledge, Attitude) and Management Practices of Diabetes Patients Attending Medical Out Patient Department in Federal Capital Territory Abuja

2021 ◽  
Author(s):  
Kulu Wakili ◽  
Tayo Micheal Anjuwon ◽  
Oluwafemi Abiodun Adepoju ◽  
Ijeoma Okolo ◽  
Binda Tembeng Andongma ◽  
...  
Keyword(s):  
Blood Glucose ◽  
Management Practices ◽  
Fasting Blood Glucose ◽  
Lifestyle Changes ◽  
Nutrition Status ◽  
Diabetic Patients ◽  
Cross Sectional Survey ◽  
Cross Sectional ◽  
Family Medical History ◽  
Diabetes Patients

Objective: The study assessed the knowledge, attitude and management practices of diabetes patients attending medical outpatient department in Federal Capital Territory Abuja. Materials and Methods: A total of 120 randomly selected respondents between 18 - 65 years were assessed using standard methods in a cross-sectional survey involving the use of validated semi-structured questionnaires. Results: The findings revealed that 60% of patients were without health insurance despite the fact that they are educated; 53% have been diagnosed and began their treatment between 2 and 5 years. For the knowledge indicators, 50% of the patients know two types of diabetes, 35% were able to list two types of diabetes while 56.70% could not list any type of diabetes. Attitude assessment among the diabetic patients revealed that 79.17%, 62.50%, 68.33% and 51.67% visit a physician; do monitor their blood glucose, have altered their eating habit and agreed that sedentary lifestyle is not good respectively; 41.67% of the respondents read health materials. In the area of lifestyle, changes made by the diabetic patients include check-up (3.33%), diet (18.33%) and exercise (20.00); 40.00% and 14.17% made a combination of two and three lifestyle changes respectively. Majority of the respondents do have their blood glucose level checked monthly. Conclusion: Based on the research findings, the diabetic patients’ knowledge, attitude and dietary practices are contributing factors to their high fasting blood glucose and poor nutrition status.

scholarly journals EFFECT OF EXERCISE ON INSULIN RESISTANCE IN OBESE TYPE 2 DIABETES PATIENTS

2022 ◽  
Vol 28 (1) ◽  
pp. 59-61
Author(s):  
Bin Zhang
Keyword(s):  
Diabetes Mellitus ◽  
Insulin Resistance ◽  
Type 2 Diabetes ◽  
Blood Glucose ◽  
Fasting Blood Glucose ◽  
Resistance Index ◽  
Control Group ◽  
Diabetic Patients ◽  
Diabetes Patients

ABSTRACT Introduction: Type 2 diabetes mellitus (T2DM), also known as non-insulin-dependent diabetes mellitus (NIDDM), accounts for more than 90% of the total number of diabetes mellitus cases and often occurs in middle-aged and elderly people. Objective: To investigate the effect of exercise intervention on insulin resistance in obese type 2 diabetes patients. Methods: Eighty-six obese diabetic patients were screened as experimental subjects in physical examinations and randomly divided into observation and control groups. Visceral fat volume, fasting blood glucose, and fasting insulin of all subjects were measured before and after completion of the 6-month experimental implementation. The insulin resistance was calculated for both groups and the values for each indicator were compared statistically between groups. Results: Control of body weight, body mass index, blood glucose, blood lipids and insulin resistance index were better in the observation group than in the control group, and the difference was statistically significant (P < 0.05). Conclusions: Basal intervention with quantitative exercise can significantly improve insulin resistance in obese type 2 diabetes patients and the effect is better than treatment with diet and conventional exercise. Level of evidence II; Therapeutic studies - investigation of treatment results.

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