scholarly journals Longitudinal Whole-Genome Analysis Identifies Variants Associated with Vancomycin and Linezolid Resistance Changes in Enterococcus faecium in Response to Treatment

2016 ◽  
Vol 3 (suppl_1) ◽  
Author(s):  
Kieran Chacko ◽  
Theodore Pak ◽  
Robert Sebra ◽  
Andrew Kasarskis ◽  
Camille Hamula ◽  
...  
Keyword(s):  
Genome Analysis ◽  
Enterococcus Faecium ◽  
Response To Treatment ◽  
Whole Genome ◽  
Whole Genome Analysis ◽  
Linezolid Resistance

Whole-genome analysis of vancomycin-resistant Enterococcus faecium causing nosocomial outbreaks suggests the occurrence of few endemic clonal lineages in Bavaria, Germany

2020 ◽  
Vol 75 (6) ◽  
pp. 1398-1404 ◽  
Author(s):  
David Eisenberger ◽  
Christian Tuschak ◽  
Markus Werner ◽  
Christian Bogdan ◽  
Thomas Bollinger ◽  
...  
Keyword(s):  
Genetic Diversity ◽  
Genome Analysis ◽  
Enterococcus Faecium ◽  
Treatment Options ◽  
Health Concern ◽  
Snp Analysis ◽  
Whole Genome ◽  
Vancomycin Resistant Enterococcus ◽  
Whole Genome Analysis ◽  
Vancomycin Resistant

Abstract Objectives Infections caused by vancomycin-resistant Enterococcus faecium (VREfm) represent a major public health concern due to limited treatment options. Among invasive isolates of VREfm, ST117, ST80 and ST78 represent the most frequently detected STs by MLST in Germany. In this study, we investigated the genetic diversity of isolates of VREfm recovered from different nosocomial outbreaks in Bavaria, Germany, by WGS. Methods Between January 2018 and April 2019, 99 non-replicate isolates of VREfm originating from nosocomial outbreaks at eight different hospitals in Bavaria were investigated for genetic diversity by WGS. In detail, complex types (CTs) were identified by core-genome MLST. Furthermore, an SNP analysis was performed for all VREfm strains. Results Most of the isolates of this study (76%) belonged to three major clonal groups, which occurred in at least three hospitals: ST80/CT1065 vanB (n = 45; six hospitals), ST117/CT71 vanB (n = 11; four hospitals) and ST78/CT894like vanA (n = 19; three hospitals). Moreover, isolates of the predominant lineage ST80/CT1065 vanB showed a maximum difference of 36 SNPs as revealed by SNP analysis. Conclusions Whole-genome analysis of VREfm causing nosocomial outbreaks suggests the occurrence of few endemic clonal lineages in Bavarian hospital settings, namely ST80/CT1065 vanB, ST117/CT71 vanB and ST78/CT894like vanA. Further studies are needed for a better understanding of the factors affecting the successful spread of the above-mentioned lineages.

scholarly journals Whole-genome analysis uncovers loss of blaZ associated to carriage isolates belonging to MRSA clone ST5-VI in Cape Verde

2021 ◽  
Author(s):  
Magdalena Wysocka ◽  
Tamar Monteiro ◽  
Carine de Pina ◽  
Deisy Gonçalves ◽  
Sandrine de Pina ◽  
...  
Keyword(s):  
Genome Analysis ◽  
Cape Verde ◽  
Whole Genome ◽  
Whole Genome Analysis

Whole-genome analysis of the ammonia-oxidizing bacterium, Nitrosomonas eutropha C91: implications for niche adaptation

2007 ◽  
Vol 9 (12) ◽  
pp. 2993-3007 ◽  
Author(s):  
Lisa Y. Stein ◽  
Daniel J. Arp ◽  
Paul M. Berube ◽  
Patrick S. G. Chain ◽  
Loren Hauser ◽  
...  
Keyword(s):  
Genome Analysis ◽  
Whole Genome ◽  
Whole Genome Analysis ◽  
Niche Adaptation ◽  
Ammonia Oxidizing Bacterium

scholarly journals Whole-Genome Analysis of Oryza sativa Reveals Similar Architecture of Two-Component Signaling Machinery with Arabidopsis

2006 ◽  
Vol 142 (2) ◽  
pp. 380-397 ◽  
Author(s):  
Ashwani Pareek ◽  
Anupama Singh ◽  
Manoj Kumar ◽  
Hemant R. Kushwaha ◽  
Andrew M. Lynn ◽  
...  
Keyword(s):  
Oryza Sativa ◽  
Genome Analysis ◽  
Whole Genome ◽  
Whole Genome Analysis ◽  
Two Component
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