scholarly journals Effectiveness of Direct-Acting Antiviral (DAA) Regimens in Genotype 1 Human Immunodeficiency Virus/Hepatitis C Virus (HIV/HCV)-Coinfected Patients: An Analysis of the Department of Veterans Affairs (VA) National Clinical Case Registry

2016 ◽  
Vol 3 (suppl_1) ◽  
Author(s):  
Debika Bhattacharya ◽  
Pamela Belperio ◽  
Troy Shahoumian ◽  
Timothy Loomis ◽  
Matthew Bidwell Goetz ◽  
...  
Keyword(s):  
Human Immunodeficiency Virus ◽  
Hepatitis C ◽  
Clinical Case ◽  
Veterans Affairs ◽  
Department Of Veterans Affairs ◽  
Virus Hepatitis ◽  
Genotype 1 ◽  
Direct Acting Antiviral ◽  
Immunodeficiency Virus ◽  
Direct Acting

scholarly journals Hepatitis C Care Continuum in a Human Immunodeficiency Virus (HIV) Positive Cohort: Data From the HIV Atlanta Veterans Affairs Cohort Study

2020 ◽  
Vol 7 (4) ◽  
Author(s):  
Ruth O Adekunle ◽  
Kathryn DeSilva ◽  
Emily J Cartwright
Keyword(s):  
Human Immunodeficiency Virus ◽  
Cohort Study ◽  
Hepatitis C ◽  
Healthcare System ◽  
Sustained Virologic Response ◽  
Virologic Response ◽  
Veterans Affairs ◽  
Resistance Mutations ◽  
Immunodeficiency Virus ◽  
Direct Acting

Abstract Background Human immunodeficiency virus (HIV) and hepatitis C virus (HCV) coinfection is associated with accelerated progression to cirrhosis, end-stage liver disease, and liver-associated death. It is fortunate that curative direct-acting antivirals for the treatment of HCV are widely available in the VA healthcare system. We attempted to identify, evaluate, and treat all HIV/HCV-coinfected persons at the Atlanta VA Healthcare System. Methods Human immunodeficiency virus/HCV-coinfected persons at Atlanta VA between 2015 and 2018 were identified using the HIV Atlanta Veterans Affairs Cohort Study and Hepatitis C VA Clinical Case Registry. Retrospective reviews of each electronic medical record were conducted by the hepatitis C clinical team for validation. The primary end point was achieving sustained virologic response. Results One hundred thirty-eight veterans with HIV and hepatitis C viremia were identified. One hundred twenty-five (90%) were evaluated for treatment and 113 (91%) were initiated on direct-acting antiviral therapy. Median age at initiation of treatment was 60 years and the majority were black race (90%). Genotype 1a was most common (70%) and 41% had compensated cirrhosis. One hundred eight completed treatment and 96% achieved sustained virologic response. Six veterans had virologic relapse; 4 had treatment-emergent resistance mutations in the NS5a gene. Mean CD4 was 580 cells/mm3 with HIV viral suppression in 82% of the cohort. In those not treated, unstable housing (25%), active substance use (31%), and psychiatric conditions (42%) were identified barriers to care. Conclusions Through a concerted, systematic effort, over 80% of HIV/hepatitis C persons in the Atlanta VA have been initiated on treatment for hepatitis C, 96% of which have been cured.

Treatment of Hepatitis C in Patients Infected with Human Immunodeficiency Virus in the Direct-Acting Antiviral Era

2012 ◽  
Vol 26 (4) ◽  
pp. 931-948 ◽  
Author(s):  
Vincent Soriano ◽  
Pablo Labarga ◽  
Eugenia Vispo ◽  
José Vicente Fernández-Montero ◽  
Pablo Barreiro
Keyword(s):  
Human Immunodeficiency Virus ◽  
Hepatitis C ◽  
Direct Acting Antiviral ◽  
Immunodeficiency Virus ◽  
Direct Acting

scholarly journals Liver Cirrhosis as a Risk Factor for Direct-Acting Antiviral Therapy Failure in Real-Life Hepatitis C Virus/Human Immunodeficiency Virus Coinfection

2017 ◽  
Vol 4 (3) ◽  
Author(s):  
Christoph Boesecke ◽  
Patrick Ingiliz ◽  
Florian Berger ◽  
Thomas Lutz ◽  
Knud Schewe ◽  
...  
Keyword(s):  
Human Immunodeficiency Virus ◽  
Liver Cirrhosis ◽  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Treatment Guidelines ◽  
Real Life ◽  
Direct Acting Antiviral ◽  
Hiv Coinfection ◽  
Immunodeficiency Virus ◽  
Direct Acting

Abstract Current hepatitis C virus (HCV) treatment guidelines recommend treating HCV/human immunodeficiency virus (HIV)-coinfected individuals similar to HCV-monoinfected individuals. Recently inferior response rates to direct acting antiviral (DAA) therapy in HCV/HIV coinfection have been reported. Our German hepatitis C cohort (GECCO) cohort data show that coinfected patients with liver cirrhosis are less likely to achieve viral eradication.

scholarly journals Antiretroviral Use in the CEASE Cohort Study and Implications for Direct-Acting Antiviral Therapy in Human Immunodeficiency Virus/Hepatitis C Virus Coinfection

2016 ◽  
Vol 3 (2) ◽  
Author(s):  
Marianne Martinello ◽  
Gregory J. Dore ◽  
Jasmine Skurowski ◽  
Rohan I. Bopage ◽  
Robert Finlayson ◽  
...  
Keyword(s):  
Human Immunodeficiency Virus ◽  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Major Advance ◽  
Potential Ddis ◽  
Direct Acting Antiviral ◽  
Immunodeficiency Virus ◽  
Hcv Coinfection ◽  
Direct Acting ◽  
Prescribing Information

AbstractBackground.  Interferon-free direct-acting antiviral (DAA) regimens for hepatitis C virus (HCV) provide a major advance in clinical management, including in human immunodeficiency virus (HIV)/HCV coinfection. Drug-drug interactions (DDIs) with combination antiretroviral therapy (cART) require consideration. This study aimed to characterize the cART regimens in HIV/HCV-coinfected individuals and assess the clinical significance of DDIs with DAAs in a real-world cohort.Methods.  This analysis included participants enrolled in CEASE-D, a prospective cohort of HIV/HCV-coinfected individuals in Sydney, Australia, between July 2014 and December 2015. A simulation of potential DDIs between participants' cART and interferon-free DAA regimens was performed using www.hep-druginteractions.org and relevant prescribing information.Results.  In individuals on cART with HCV genotype (GT) 1 and 4 (n = 128), category 3 DDIs (contraindicated or not recommended) were noted in 0% with sofosbuvir/ledipasvir, 0% with sofosbuvir plus daclatasvir, 17% with sofosbuvir/velpatasvir, 36% with ombitasvir/paritaprevir/ritonavir ± dasabuvir, 51% with grazoprevir/elbasvir, and 51% with sofosbuvir plus simeprevir; current cART regimens were suitable for coadministration in 100%, 100%, 73%, 64%, 49%, and 49%, respectively. In individuals with HCV GT 2 or 3 (n = 53), category 3 DDIs were evident in 0% with sofosbuvir plus daclatasvir, 0% with sofosbuvir and ribavirin, and 13% with sofosbuvir/velpatasvir; current cART regimens were suitable in 100%, 100%, and 81%, respectively.Conclusions.  Potential DDIs are expected and will impact on DAA prescribing in HIV/HCV coinfection. Sofosbuvir in combination with an NS5A inhibitor or ribavirin appeared to be the most suitable regimens in this cohort. Evaluation of potential DDIs is required to prevent adverse events or treatment failure.

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