scholarly journals Markers of CNS Injury in Adults Living With HIV With CSF HIV Not Detected vs Detected <20 Copies/mL

2019 ◽  
Vol 6 (12) ◽  
Author(s):  
Shelli F Farhadian ◽  
Hetal Mistry ◽  
Tobias Kirchwey ◽  
Jennifer Chiarella ◽  
Rachela Calvi ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Neuropsychological Testing ◽  
Cns Injury ◽  
Limit Of Quantification ◽  
Barrier Integrity ◽  
Hiv Rna ◽  
Standard Assay ◽  
Cns Pathology ◽  
Living With Hiv ◽  
Blood Brain Barrier Integrity

Abstract The presence of quantifiable HIV RNA in cerebrospinal fluid (CSF) during antiretroviral therapy (ART) can associate with central nervous system (CNS) pathology, but the significance of RNA detected below the limit of quantification (LOQ) on a standard assay during ART remains unknown. We compared CNS parameters between individuals with CSF RNA detected below the LOQ (20 copies/mL) with those with HIV RNA not detected. Detection of CSF HIV RNA associated with decreased blood–brain barrier integrity and with decreased executive function, but not with CNS immune activation or poorer performance in overall neuropsychological testing.

scholarly journals Endothelial β-Catenin Signaling Is Required for Maintaining Adult Blood–Brain Barrier Integrity and Central Nervous System Homeostasis

Circulation ◽  
2016 ◽  
Vol 133 (2) ◽  
pp. 177-186 ◽  
Author(s):  
Khiem A. Tran ◽  
Xianming Zhang ◽  
Dan Predescu ◽  
Xiaojia Huang ◽  
Roberto F. Machado ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Blood Brain Barrier ◽  
Brain Barrier ◽  
Barrier Integrity ◽  
Blood Brain ◽  
Blood Brain Barrier Integrity

scholarly journals Gpr124 is essential for blood–brain barrier integrity in central nervous system disease

2017 ◽  
Vol 23 (4) ◽  
pp. 450-460 ◽  
Author(s):  
Junlei Chang ◽  
Michael R Mancuso ◽  
Carolina Maier ◽  
Xibin Liang ◽  
Kanako Yuki ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Blood Brain Barrier ◽  
Central Nervous System Disease ◽  
Nervous System Disease ◽  
Brain Barrier ◽  
Barrier Integrity ◽  
System Disease ◽  
Blood Brain ◽  
Blood Brain Barrier Integrity

A rare case of HIV CNS escape in a patient previously considered a viral controller

2020 ◽  
Vol 31 (7) ◽  
pp. 694-698
Author(s):  
Jessica Magid-Bernstein ◽  
Chu-Yueh Guo ◽  
Felicia C Chow ◽  
Kiran T Thakur
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Hiv Infection ◽  
Viral Suppression ◽  
Cns Infection ◽  
People Living With Hiv ◽  
Hiv Rna ◽  
Perinatal Hiv ◽  
The Central Nervous System ◽  
Living With Hiv

Human immunodeficiency virus (HIV) ribonucleic acid (RNA) levels generally remain undetectable in the cerebrospinal fluid of people living with HIV with peripheral viral suppression. Secondary HIV central nervous system (CNS) escape refers to the rare independent replication of HIV RNA in the central nervous system despite peripheral viral suppression that occurs in the setting of a concomitant non-HIV infection. We describe here a young man with perinatal HIV infection considered a viral controller who developed secondary HIV CNS escape in the setting of a presumed fungal CNS infection.

scholarly journals Lipoic Acid Affects Cellular Migration into the Central Nervous System and Stabilizes Blood-Brain Barrier Integrity

2006 ◽  
Vol 177 (4) ◽  
pp. 2630-2637 ◽  
Author(s):  
Gerty Schreibelt ◽  
René J. P. Musters ◽  
Arie Reijerkerk ◽  
Lody R. de Groot ◽  
Susanne M. A. van der Pol ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Blood Brain Barrier ◽  
Lipoic Acid ◽  
Cellular Migration ◽  
Brain Barrier ◽  
Barrier Integrity ◽  
Blood Brain ◽  
The Central Nervous System ◽  
Blood Brain Barrier Integrity
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