Neural Mechanisms Underlying Pain

2018 ◽  
Author(s):  
Massieh Moayedi ◽  
Karen D. Davis
Keyword(s):  
Chronic Pain ◽  
Historical Development ◽  
Pain Treatment ◽  
Behavioral Responses ◽  
Neural Mechanisms ◽  
Imaging Studies ◽  
Defensive Behaviors ◽  
Chronic Pain Treatment ◽  
Personalized Approach ◽  
The Brain

The chapter reviews brain imaging studies investigating the sensory, affective, cognitive, and motivational components of pain. It highlights the historical development and significant advancements in thinking about pain, its representation in the brain, its interactions with and impact on cognition, and how it motivates defensive behaviors. Modern imaging and electro-physiological approaches that are currently being applied to study pain are rapidly accumulating data pertaining to acute pain and its transition to chronic pain states in the context of individual psychological factors and behavioral responses so that in the coming era pain science can work toward a more precise and personalized approach to chronic pain treatment.

INTRATHECAL OPIOIDS IN THE INTRA - AND POSTOPERATIVE PAIN MANAGEMENT

2013 ◽  
pp. 89-94
Author(s):  
Van Minh Nguyen
Keyword(s):  
Chronic Pain ◽  
Regional Anesthesia ◽  
Historical Development ◽  
Pain Treatment ◽  
Opioid Analgesics ◽  
Perioperative Period ◽  
Postoperative Pain Management ◽  
Clinical Use ◽  
Chronic Pain Treatment ◽  
Intrathecal Analgesia

Opioid analgesics have long been considered as among the most effective treatments for pain, but these medications was used without a fully known mechanism of action until finding its receptor. The discovery of opioid receptors in the dorsal horn has opened a new pain treatment. Intrathecal opioids are widely used as useful adjuncts to anesthesia during regional anesthesia, in the treatment of postoperative acute pain and chronic pain treatment. This article summarizes the historical development and examines the current use of intrathecal opioids in the perioperative period. Pharmacology and clinical use were also reviewed in detail, including dosage in different surgeries, side effects and the treatment. Key words: opioid, intrathecal analgesia, regional anesthesia

Yoga as an Effective Mind--Body Therapy in Chronic-Pain Treatment

2007 ◽  
Author(s):  
Malinda Breda ◽  
Richard Gevirtz ◽  
Melanie A. Greenberg ◽  
James L. Spira
Keyword(s):  
Chronic Pain ◽  
Pain Treatment ◽  
Body Therapy ◽  
Chronic Pain Treatment

scholarly journals Telemedicine for chronic pain treatment during the COVID‐19 pandemic: Do pain intensity and anxiousness correlate with patient acceptance?

Pain Practice ◽  
2021 ◽  
Author(s):  
Michael Alexander Harnik ◽  
Larissa Blättler ◽  
Andreas Limacher ◽  
Florian Reisig ◽  
Martin Grosse Holtforth ◽  
...  
Keyword(s):  
Chronic Pain ◽  
Pain Intensity ◽  
Pain Treatment ◽  
Patient Acceptance ◽  
Chronic Pain Treatment

Problematic Prescription Opioid Use in a Chronic Pain Treatment Facility: The Role of Emotional Processes

2018 ◽  
Vol 54 (3) ◽  
pp. 495-505 ◽  
Author(s):  
Lindsay M. S. Oberleitner ◽  
Mark A. Lumley ◽  
Emily R. Grekin ◽  
Kathryn M. Z. Smith ◽  
Amy M. Loree ◽  
...  
Keyword(s):  
Chronic Pain ◽  
Pain Treatment ◽  
Prescription Opioid ◽  
Opioid Use ◽  
Treatment Facility ◽  
Emotional Processes ◽  
Chronic Pain Treatment ◽  
Prescription Opioid Use

scholarly journals Optogenetics and photopharmacology in pain research and therapeutics

STEMedicine ◽  
2020 ◽  
Vol 1 (3) ◽  
pp. e43 ◽  
Author(s):  
Federico Iseppon ◽  
Manuel Arcangeletti
Keyword(s):  
Chronic Pain ◽  
Pain Treatment ◽  
Molecular Switches ◽  
Genetic Profiling ◽  
Pain Research ◽  
Recent Advances ◽  
Cellular Components ◽  
The Brain

Pain afflicts billions of people worldwide, who suffer especially from long-term chronic pain. This gruelling condition affects the nervous system at all levels: from the brain to the spinal cord, the Dorsal Root Ganglia (DRG) and the peripheral fibres innervating the skin. The nature of the different molecular and cellular components of the somatosensory modalities, as well as the complexity of the peripheral and central circuitry are yet poorly understood. Light-based techniques such as optogenetics, in concert with the recent advances in single-cell genetic profiling, can help to elucidate the role of diverse neuronal sub-populations in the encoding of different sensory and painful stimuli by switching these neurons on and off via optically active proteins, namely opsins.  Recently, photopharmacology has emerged from the efforts made to advance optogenetics. The introduction of azo-benzene-based light-sensitive molecular switches has been applied to a wide variety of molecular targets, from ion channels and receptors to transporters, enzymes and many more, some of which are paramount for pain research and therapy. In this Review, we summarise the recent advances in the fields of optogenetics and photopharmacology and we discuss the use of light-based techniques for the study of acute and chronic pain physiology, as well as their potential for future therapeutic use to improve pain treatment.

scholarly journals Drop-out from chronic pain treatment programmes: Is randomization justified in biopsychosocial approaches?

2021 ◽  
pp. 0
Author(s):  
A Bicego ◽  
J Monseur ◽  
F Rousseaux ◽  
M Faymonville ◽  
N Malaise ◽  
...  
Keyword(s):  
Chronic Pain ◽  
Pain Treatment ◽  
Drop Out ◽  
Chronic Pain Treatment
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