The Four Noble Truths

2021 ◽  
pp. 71-89
Author(s):  
Jay L. Garfield

The four noble truths are the foundation of all of Buddhist thought, and especially ethical thought. This chapter examines Buddhist insight into the ways that suffering pervades every aspect of our lives, and the importance of the many different levels of suffering, including suffering from shame, suffering of change, and suffering of pervasive conditioning. The chapter also covers the Buddhist account of the origins of suffering, from the three pathologies of primal confusion, attraction, and aversion. Finally, it addresses the aspects of the eightfold path, and its applications as a way to attain the cessation of these forms of suffering.

Sexualities ◽  
2020 ◽  
pp. 136346072098169
Author(s):  
Aidan McKearney

This article focuses on the experiences of gay men in the rural west and northwest region of Ireland, during a period of transformational social and political change in Irish society. These changes have helped facilitate new forms of LGBTQI visibility, and local radicalism in the region. Same-sex weddings, establishment of rural LGBT groups and marching under an LGBT banner at St Patricks Day parades would have been unthinkable in the recent past; but they are now becoming a reality. The men report continuing challenges in their lives as gay men in the nonmetropolitan space, but the emergence of new visibility, voice and cultural acceptance of LGBT people is helping change their lived experiences. The study demonstrates the impact of local activist LGBT citizens. Through their testimonies we can gain an insight into the many, varied and interwoven factors that have interplayed to create the conditions necessary for the men to: increasingly define themselves as gay to greater numbers of people in their localities; to embrace greater visibility and eschew strategies of silence; and aspire to a host of legal, political, cultural and social rights including same-sex marriage. Organic forms of visibility and local radicalism have emerged in the region and through an analysis of their testimonies we can see how the men continue to be transformed by an ever-changing landscape.


2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Haomiao Cheng ◽  
Zhanru Shao ◽  
Chang Lu ◽  
Delin Duan

Abstract Background The nitrogen-containing polysaccharide chitin is the second most abundant biopolymer on earth and is found in the cell walls of diatoms, where it serves as a scaffold for biosilica deposition. Diatom chitin is an important source of carbon and nitrogen in the marine environment, but surprisingly little is known about basic chitinase metabolism in diatoms. Results Here, we identify and fully characterize 24 chitinase genes from the model centric diatom Thalassiosira pseudonana. We demonstrate that their expression is broadly upregulated under abiotic stresses, despite the fact that chitinase activity itself remains unchanged, and we discuss several explanations for this result. We also examine the potential transcriptional complexity of the intron-rich T. pseudonana chitinase genes and provide evidence for two separate tandem duplication events during their evolution. Conclusions Given the many applications of chitin and chitin derivatives in suture production, wound healing, drug delivery, and other processes, new insight into diatom chitin metabolism has both theoretical and practical value.


Materials ◽  
2018 ◽  
Vol 11 (12) ◽  
pp. 2557 ◽  
Author(s):  
Seo Lee ◽  
Jae Kang ◽  
Dokyoung Kim

Porous silicon has been utilized within a wide spectrum of industries, as well as being used in basic research for engineering and biomedical fields. Recently, surface modification methods have been constantly coming under the spotlight, mostly in regard to maximizing its purpose of use. Within this review, we will introduce porous silicon, the experimentation preparatory methods, the properties of the surface of porous silicon, and both more conventional as well as newly developed surface modification methods that have assisted in attempting to overcome the many drawbacks we see in the existing methods. The main aim of this review is to highlight and give useful insight into improving the properties of porous silicon, and create a focused description of the surface modification methods.


2020 ◽  
Vol 24 (3) ◽  
pp. 493-526
Author(s):  
JOAN C. BEAL ◽  
RANJAN SEN ◽  
NURIA YÁÑEZ-BOUZA ◽  
CHRISTINE WALLIS

Yod-coalescence involving alveolar consonants before Late Modern English /uː/ from earlier /iu > juː/ is still variable and diffusing in Present-day English. For example, the Oxford English Dictionary (OED) gives both (/tj dj/) and (/ʧ ʤ/) British English pronunciations for tune (/tjuːn/, /tʃuːn/), mature (/mǝˈtjʊǝ/, /mǝˈʧʊǝ/), duke (/djuːk/, /dʒuːk/) and endure (/ᵻnˈdjʊə/, /ɛnˈdjʊə/, /ᵻnˈdʒʊə/, /ɛnˈdʒʊə/, /ᵻnˈdjɔː/, /ɛnˈdjɔː/, /ᵻnˈdʒɔː/, /ɛnˈdʒɔː/). Extensive variability in yod-coalescence and yod-dropping is not recent in origin, and we can already detect relevant patterns in the eighteenth century from the evidence of a range of pronouncing dictionaries. Beal (1996, 1999) notes a tendency for northern English and Scottish authors to be more conservative with regard to yod-coalescence. She concludes that we require ‘a comprehensive survey of the many pronouncing dictionaries and other works on pronunciation’ (1996: 379) to gain more insight into the historical variation patterns underlying Present-day English.This article presents some results from such a ‘comprehensive survey’: the Eighteenth-Century English Phonology Database (ECEP). Transcriptions of all relevant words located are compared across a range of eighteenth-century sources in order to determine the chronology of yod-coalescence and yod-dropping as well as internal (e.g. stress, phoneme type, presence of a following /r/) and external (e.g. prescriptive, geographical, social) motivations for these developments.


2020 ◽  
Author(s):  
Justin Martin ◽  
Kyleigh Leddy ◽  
Liane Young ◽  
Katherine McAuliffe

Among the many factors that influence our moral judgments, two are especially important: whether the person caused a bad outcome and whether they intended for it to happen. Notably, the weight accorded to these factors in adulthood varies by the type of judgment being made. For punishment decisions, intentions and outcomes carry relatively equal weight; for partner choice decisions (i.e., deciding whether or not to interact with someone again), intentions are weighted much more heavily. These behavioral differences in punishment and partner choice judgments may also reflect more fundamental differences in the cognitive processes supporting these decisions. Exploring how punishment and partner choice emerge in development provides important and unique insight into these processes as they emerge and mature. Here, we explore the developmental emergence of punishment and partner choice decisions in 4- to 9-year-old children. Given the importance of intentions for partner choice decisions¬–from both theoretical and empirical perspectives–we targeted the sensitivity of these two responses to others’ intentions as well as outcomes caused. Our punishment results replicate past work: young children are more focused on outcomes caused and become increasingly sensitive to intentions with age. In contrast, partner choice judgments exhibit sensitivity to intentions at an earlier age than punishment judgments, manifesting as earlier partner choice in cases of attempted violations. These results reveal distinct developmental trajectories for punishment and partner choice judgments, with implications for our understanding of the processes underlying these two responses as well as the development of moral judgment more broadly.


2021 ◽  
Vol 40 (3) ◽  
pp. 93-126
Author(s):  
Michael Lewin

Transcendental philosophy was not born like Athena out of Zeus’s head, mature and in full armour from the very beginning. That is why in both prefaces to the Critique of Pure Reason (1781 and 1787) Kant introduces the concept of transcendental philosophy as an “idea.” The idea understood architectonically develops slowly and only gradually acquires a definite form. As witnessed by the works of Kant himself and of his predecessors and followers, the idea of transcendental philosophy has undergone a series of changes and adjustments compared to the initial plan. In this context, my goal is not simply exegesis and historical investigation of transcendental philosophy, but also to look at it from a systematic and methodological perspective. I examine the concept of transcendental philosophy from the viewpoint of programmatic metaphilosophy. The first part discusses programmatics as a distinct subsection of metaphilosophy. I argue that Kant’s architectonic methodology and the methodology of Lakatos can be used to understand the inception, development and degradation of philosophical systems. In the second part I look at the project of transcendental philosophy and the stages of its development from the standpoint of architectonics. The third part shows that Lakatos’s methodology can provide a detailed insight into the elements of transcendental philosophy, a clear idea of its logic and identify the component parts that can be improved and developed. In spite of the different levels of detailing and epistemological prerequisites, the methodologies of Kant and Lakatos can be combined to achieve a metaphilosophically informed and progressive understanding of philosophical projects.


2021 ◽  
Vol 12 ◽  
Author(s):  
Ulrich Hegerl ◽  
Ines Heinz ◽  
Ainslie O'Connor ◽  
Hannah Reich

Due to the many different factors contributing to diagnostic and therapeutic deficits concerning depression and the risk of suicidal behaviour, community-based interventions combining different measures are considered the most efficient way to address these important areas of public health. The network of the European Alliance Against Depression has implemented in more than 120 regions within and outside of Europe community-based 4-level-interventions that combine activities at four levels: (i) primary care, (ii) general public, (iii) community facilitators and gatekeepers (e.g., police, journalists, caregivers, pharmacists, and teachers), and (iv) patients, individuals at high risk and their relatives. This review will discuss lessons learned from these broad implementation activities. These include targeting depression and suicidal behaviour within one approach; being simultaneously active on the four different levels; promoting bottom-up initiatives; and avoiding any cooperation with the pharmaceutical industry for reasons of credibility.


2003 ◽  
Vol 81 (3) ◽  
pp. 161-167 ◽  
Author(s):  
Katherine L Dunn ◽  
James R Davie

The nuclear factor CTCF was first identified as one of the factors binding to the regulatory regions of the c-myc gene. Further study of this protein revealed roles in transcriptional repression, insulator function, and imprinting genetic information. Recent studies have provided new insight into the mechanism through which this factor acts at various levels of gene regulation.Key words: CTCF, insulator, transcription.


Author(s):  
Carey K. Morewedge ◽  
Daniella M. Kupor

Intuitions, attitudes, images, mind-wandering, dreams, and religious messages are just a few of the many kinds of uncontrolled thoughts that intrude on consciousness spontaneously without a clear reason. Logic suggests that people might thus interpret spontaneous thoughts as meaningless and be uninfluenced by them. By contrast, our survey of this literature indicates that the lack of an obvious external source or motive leads people to attribute considerable meaning and importance to spontaneous thoughts. Spontaneous thoughts are perceived to provide meaningful insight into the self, others, and the world. As a result of these metacognitive appraisals, spontaneous thoughts substantially affect the beliefs, attitudes, decisions, and behavior of the thinker. We present illustrative examples of the metacognitive appraisals by which people attribute meaning to spontaneous secular and religious thoughts, and the influence of these thoughts on judgment and decision-making, attitude formation and change, dream interpretation, and prayer discernment.


Author(s):  
Janet R. Meyer

The messages spoken in everyday conversation are influenced by participants’ goals. Interpersonal scholars have distinguished two types of goals thought to influence the wording of a message: instrumental goals (primary goals) and secondary goals. An instrumental goal is related to a speaker’s primary reason for designing the message. Instrumental goals would include goals such as to ask for a favor, seek information, apologize, give advice, or change the other person’s opinion. Secondary goals pertain to more general concerns. They include goals such as to manage one’s impression, avoid offending the hearer, and act consistently with one’s values. The ability to design a message that pursues an instrumental goal effectively while also addressing (or at least not conflicting with) relevant secondary goals is associated with greater communication competence. Considerable research has sought to explain differences in the ability to design messages that effectively address multiple goals. One such factor appears to be the extent to which a speaker can adapt the language of a message to the communication-relevant features of a specific situation or hearer. If a speaker’s primary goal is to seek a favor, relevant situation features may include the speaker’s right to ask, expected resistance, and qualities of the speaker–hearer relationship. A second behavior associated with the ability to produce multiple-goal messages is suggested by research on cognitive editing. The latter research indicates that the likelihood of producing a message that addresses relevant secondary goals will sometimes depend upon whether a speaker becomes aware, prior to speaking, that a planned message could have an unwanted outcome (e.g., the message may offend the hearer). When such outcomes are anticipated in advance, the message may be left unspoken or edited prior to speaking. The ability to produce a message that achieves a speaker’s goals may also depend on the type of planning that precedes the design of a message. The plan-based theory of strategic communication views plans as hierarchical structures that specify goals and actions at different levels of specificity. The theory holds that a person pursuing a goal first tries to retrieve from memory a preexisting plan that could be modified for the current situation. When that is not possible, speakers must formulate a novel plan. Research employing indicants of fluency suggests that formulating a novel plan (which requires changes at a higher, more abstract level of a plan) makes heavier demands on limited capacity than does modifying an existing plan at a lower level of the hierarchy (e.g., speaking more slowly). Insight into how persons plan what to say has also come from research on imagined interactions, conflict management, anticipating obstacles to compliance, and verbal disagreement tasks. In an effort to better understand the design of messages in interpersonal settings, a number of scholars have proposed models of the cognitive processes and structures thought to be involved in designing, editing, and producing such messages. Action models of this sort, which generate testable hypotheses, draw from work in artificial intelligence, cognitive models of language production, and research on social cognition. Three such models are action assembly theory, the cognitive rules model, and the implicit rules model.


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