scholarly journals Correlation between Atherogenic index and the severity of coronary artery disease in diabetic patients undergoing elective coronary angiography using Gensini score

QJM ◽  
2020 ◽  
Vol 113 (Supplement_1) ◽  
Author(s):  
A S Elyamani ◽  
M A Elnozahi ◽  
A M Abdelmoteleb
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Coronary Angiography ◽  
Significant Positive Correlation ◽  
Atherogenic Index ◽  
Diabetic Patients ◽  
Gensini Score ◽  
Atherogenic Index Of Plasma ◽  
Positive Correlation ◽  
Artery Disease

Abstract Background Dyslipidemia is one of the most important factors for CAD. Atherogenic index of plasma (AIP) is a new indicator involved in dyslipidemia. However, its relation with CAD severity in diabetic patients is not well established yet. Aim of the Study To study the relationship between atherogenic index of plasma and severity of coronary artery disease (CAD) in the diabetic patients. Methods Our study was conducted on 150 diabetic patient with stable CAD undergoing elective coronary angiography in Al-Agoza Hospital from april 2016 to august 2018. Atherogenic index was calculated from the logarithmically transformed ratio of concentrations of TGs to HDL-C obtained from the patient’s lipid profile. correlation of the AIP and the severity of CAD according to Gensini scoring system was done. Results AIP had a statistically significant positive relation with IDDM (p = 0.033), NIDDM (p = 0.033), HTN (p = 0.024), dyslipedemia (p = 0.042). And a highly significant positive correlation with FBS (p < 0.001, r = 0.479) and HbA1c (p < 0.001, r = 0.538), proximal LAD lesions (p = 0.002), LCX (p < 0.001), and the number of vessls affected (p = 0.005). AIP Also had a highly significant positive correlation with severity of CAD in terms of Gensini score (p < 0.001, r = 0.692). Conclusion AIP is considered a good predictor of CAD severity and multivessel affection in diabetic patients.

Serum Interleukin-6 and Lipid Atherogenic Index Risk Ratios as Interpreters of Cardiac Disease in Obese and Non Obese Male Patients of Coronary Artery Disease

2021 ◽  
Vol 15 (6) ◽  
pp. 1203-1205
Author(s):  
S. Naz ◽  
M. Raza ◽  
A. Akbar ◽  
A. N. Zaidi ◽  
S. Khaliq ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Lipid Profile ◽  
Interleukin 6 ◽  
Significant Positive Correlation ◽  
Atherogenic Index ◽  
Positive Correlation ◽  
Male Patients ◽  
Artery Disease ◽  
Obese Male

Aim: To evaluate serum Interleukin-6, and lipids as predictors of cardiovascular diseases (CVD) in obese and non obese male patients of coronary artery disease (CAD). Methodology: It was cross-sectional comparative study. Serum Interleukin-6 and lipid profile was determined in non diabetic, non smoker and non hypertensive age matched obese and non obese male patients of CAD and healthy subjects. Sixty male subjects were divided equally into groups. Group 1, healthy controls (n=20), group 2, non obese male patients with CAD (n=20) and group 3 included Obese male patients with CAD (n=20). The serum was assayed for lipid profile and interleukin-6 . Results: Age matched healthy and patients were non diabetics, non hypertensive and non smoker with altered lipid profile in obese and non obese male patients with coronary artery disease. Patients have high serum cholesterol, low density cholesterol(LDL-C), Triglyceride(TG,) very low density lipoprotein(VLDL) and interleukin-6. The High density lipoprotein was lowered in both obese and non obese male patients with CAD. Significant positive correlation was observed in CAD group of IL-6 with TC (rho= 0.405, p= 0.009*) , with TG (rho= 0.639, p= 0.000*) ,with LDL (rho= 0.398, p= 0.002*), with VLDL (rho= 0.315, p= 0.014*). Significant negative correlation was observed in CAD group of IL-6 with HDL (rho= -0.565, p= 0.000*) Significant positive correlation was observed in CAD group of IL-6 .Significant positive correlation of IL-6 was observed with AI (rho= 0.602, p= 0.000*). Conclusion: Dyslipidemia, Raised interleukin-6 and strong positive correlation of Atherogenic index with IL-6 are independent risk factors for CVD; using Atherogenic risk ratios as a screening tool for the estimation of CVD risk is useful in patients with CAD. Keywords: Lipid profile, serum interleukin-6,Atherogenic index,coronary artery disease.

scholarly journals Association of Glycosylated Haemoglobin Level with the Severity of Coronary Artery Disease in NSTEMI Diabetic Patients

2015 ◽  
Vol 8 (1) ◽  
pp. 43-48
Author(s):  
Mahmod Mohammad Salim ◽  
Malik Fazila Tun Nesa ◽  
Rahman Mohammad Arif ◽  
Hossain Mohammad Delwar ◽  
Mandal Md Raihan Masum
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Diabetic Patients ◽  
Gensini Score ◽  
Vessel Disease ◽  
Triple Vessel Disease ◽  
Group I ◽  
Group Ii ◽  
Artery Disease ◽  
Vessel Score

Background: Relation between diabetes mellitus and ischemic heart disease is well established. But the effect of HbA1C on severity of coronary artery disease remains uncertain in non-ST elevation myocardial infarction and diabetic patient. Objective of our study was to know the relationship of HbA1C with the severity of coronary artery disease.Methods: In this cross sectional analytical study a total of 104 NSTEMI diabetic patients were enrolled by purposive sampling. They were divided into two groups according to the level of HbA1C, Group-I patients having HbA1C<7% and Group-II patients having HbA1C >7%. Vessel score and Gensini score was calculated from coronary angiogram and compared between groups.Results: Single vessel disease were significantly higher in group-I compared to Group-II( 38.5% vs 7.7% in Group-I vs Group-II,p<0.05). Double vessel disease were higher in group-II compared to Group-I but the difference was statistically not significant (42.3% vs 48.1% in Group-I vs Group-II respectively (p>0.05). Triple vessel disease were significantly higher in group-II compared to Group- I (19.2% vs 44.4% in Group-I vs Group-II,p<0.05). Mean Vessel score was higher in Group-II compared to Group-I(1.73 ± 0.86 vs 2.50 ±0.70 in Group-I vs Group-II, p<0.05). Mean Gensini score was higher in Group-II compared to Group-I (44.6 ± 38.4 vs 76.9 ± 44.6 in Group-I vs Group-II, p<0.05). There were significant positive linear correlation between HbA1C and Vessels score and Gensini score (p<0.05).Conclusion: This study may be concluded that the presence of HbA1C >7% are associated with of severe coronary artery disease in NSTEMI with diabetes mellitus.Cardiovasc. j. 2015; 8(1): 43-48

ATHEROGENIC INDEX OF PLASMA IS A MARKER OF PLAQUE VULNERABILITY IN CORONARY ARTERY DISEASE

CHEST Journal ◽  
2018 ◽  
Vol 154 (4) ◽  
pp. 85A-86A
Author(s):  
YUB RAJ SEDHAI ◽  
SONEY BASNYAT ◽  
PRASAD KONDA ◽  
AJAY KOIRALA ◽  
PARITOSH PRASAI ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Atherogenic Index ◽  
Plaque Vulnerability ◽  
Atherogenic Index Of Plasma ◽  
Artery Disease

Epicardial fat study-AG: relationship between echocardiographic epicardial fat and coronary artery disease in patients after invasive coronary artery angiography

2020 ◽  
Author(s):  
Ilenia Alessandra Di Liberto ◽  
Gerlando Pilato ◽  
Sergio Buccheri ◽  
Salvatore Geraci ◽  
Diego Milazzo ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Coronary Angiography ◽  
Invasive Coronary Angiography ◽  
Epicardial Fat ◽  
Clear Correlation ◽  
Syntax Score ◽  
Gensini Score ◽  
Coronary Artery Angiography ◽  
Artery Disease

Background: Epicardial fat increase has not yet a clear correlation with coronary artery disease (CAD). Aim: This study had as goal to demonstrate a relationship between an increase of epicardial fat thickness (EFT) and CAD. Materials & methods: In this observational study, we included 234 patients who underwent invasive coronary angiography. Before invasive coronary angiography, all patients underwent echocardiographic-2D for evaluation of EFT and they were divided into groups based on Gensini score and also on Syntax score. Results: EFT was significantly correlated to the presence and severity of CAD assessed by Gensini score with a cut-off value of 5.2 mm (sensitivity of 90.9%-specificity of 87.3%- area under the ROC curve = 92.1%). Conclusion: EFT increase (fat index ≥5.2 mm) evaluated by echocardiographic-2D could be considered as a risk factor for predicting CAD.

scholarly journals Association of classical risk factors and coronary artery disease in type 2 diabetic patients submitted to coronary angiography

2014 ◽  
Vol 6 (1) ◽  
pp. 46 ◽  
Author(s):  
Célia Bittencourt ◽  
Valdecira M Piveta ◽  
Carolina SV Oliveira ◽  
Felipe Crispim ◽  
Deyse Meira ◽  
...  
Keyword(s):  
Risk Factors ◽  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Coronary Angiography ◽  
Diabetic Patients ◽  
Type 2 Diabetic Patients ◽  
Artery Disease ◽  
Type 2 Diabetic

scholarly journals Atherogenic Index of Plasma and Coronary Artery Disease in the Adult Population: A Meta-Analysis

2021 ◽  
Vol 8 ◽  
Author(s):  
Jing Wu ◽  
Qiang Zhou ◽  
Zhouxia Wei ◽  
Jinying Wei ◽  
Meizi Cui
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Observational Studies ◽  
Meta Analysis ◽  
Adult Population ◽  
Atherogenic Index ◽  
Current Evidence ◽  
Atherogenic Index Of Plasma ◽  
Adjusted Risk ◽  
Artery Disease

Background: The atherogenic index of plasma (AIP), which is the logarithm of the ratio between the triglyceride and high-density lipoprotein cholesterol (TG/HDL-C) concentrations in molar units, is correlated with the burden of atherosclerosis. This study aimed to evaluate the association between the AIP and coronary artery disease (CAD) in the adult population by performing a meta-analysis.Methods: Observational studies relevant for this meta-analysis were identified by searching the PubMed, Embase, and Web of Science databases. Only studies using multivariate analysis were considered. A random-effects model, which incorporates potential intra-study heterogeneity, was applied to combine the results.Results: Ten observational studies were included. In studies with the AIP analyzed as a continuous variable, a higher AIP was associated with a higher odds of CAD (adjusted risk ratio [RR] per 1-standard deviation [SD] increment of AIP: 2.10, 95% confidence interval [CI]: 1.51–2.93, P &lt; 0.001, I2 = 90%). Further analysis of studies with the AIP analyzed as a categorical variable showed a higher odds of CAD (adjusted RR: 2.35, 95% CI: 1.88–2.93, P &lt; 0.001, I2 = 37%) in the participants with the highest versus the lowest AIP value. Subgroup analyses demonstrated consistent results in asymptomatic and symptomatic populations as well as in male and female participants (all between-group P values &gt; 0.05).Discussion: Current evidence, mostly from cross-sectional studies, suggests that a higher AIP value may be independently associated with CAD in the adult population.

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