scholarly journals Effects of fenofibrate therapy on renal function in primary gout patients

Rheumatology ◽  
2021 ◽  
Author(s):  
Xinde Li ◽  
Wenyan Sun ◽  
Jie Lu ◽  
Yuwei He ◽  
Ying Chen ◽  
...  
Keyword(s):  
Risk Factors ◽  
Treatment Period ◽  
Mixed Model ◽  
Interaction Analysis ◽  
Serum Urate ◽  
Factors Affecting ◽  
Primary Gout ◽  
Potential Risk Factors ◽  
Multivariable Regression ◽  
Risk Predictors

Abstract Objective To investigate the incidence and potential risk factors for development of fenofibrate-associated nephrotoxicity in gout patients. Methods A total of 983 gout patients on fenofibrate treatment who visited the dedicated Gout Clinic at the Affiliated Hospital of Qingdao University between September 2016 and June 2020 were retrospectively enrolled from the electronic records system. Fenofibrate-associated nephrotoxicity was defined as an increase in serum creatinine (SCr) ≥0.3 mg/dl within 6 months of fenofibrate initiation. The change trend of SCr and uric acid levels during the treatment period were assessed by a generalised additive mixed model (GAMM). Multivariate analysis was performed for risk factors affecting elevated SCr. Results A total of 100 (10.2%) patients experienced an increase in SCr ≥0.3 mg/dl within 6 months after fenofibrate initiation. The median change of SCr in the whole cohort was 0.11 mg/dl [interquartile range (IQR) 0.03–0.20], whereas it was 0.36 (0.33–0.45) in the fenofibrate-associated nephrotoxicity group. In a multivariable regression model, chronic kidney disease (CKD) [odds ratio (OR) 2.39 (95% CI 1.48, 3.86)] and tophus [OR 2.29 (95% CI 1.39, 3.78)] were identified to be risk predictors, independent of measured covariates, of fenofibrate-associated nephrotoxicity. During the treatment period, although SCr temporarily increased, serum urate and triglyceride concentrations decreased using the interaction analysis of GAMM. Of those with fenofibrate withdrawal records, the SCr increase in 65% of patients was reversed after an average of 49 days off the drug. Conclusions This observational study implied that fenofibrate-associated nephrotoxicity occurs frequently in gout patients, especially in patients with tophi or CKD. The potential renal risks of fenofibrate usage in gout needs additional research.

scholarly journals Factors affecting the incidence of postoperative periprosthetic fractures following primary and revision hip arthroplasty: a systematic review and meta-analysis

2021 ◽  
Vol 16 (1) ◽  
Author(s):  
Christos Bissias ◽  
Angelos Kaspiris ◽  
Athanasios Kalogeropoulos ◽  
Konstantinos Papoutsis ◽  
Nikolaos Natsioulas ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Risk Factors ◽  
Systematic Review ◽  
Meta Analysis ◽  
Revision Arthroplasty ◽  
Female Gender ◽  
Periprosthetic Fractures ◽  
Factors Affecting ◽  
Potential Risk Factors ◽  
Grade 3

Abstract Objectives The increasing number of hip arthroplasties (HA), due to the growing elderly population, is associated with the risk of femoral periprosthetic fractures (FPFs). The purpose of this study was to identify potential risk factors for the development of FPFs after HA. Methods A systematic review was conducted in five data bases (Medline, Embase, Cochrane, Cinahl, ICTRP) according to the Preferred Reporting Items for Systematic reviews and Meta-analysis (PRISMA) guidelines up to May 2019, using the key words “risk factor,” “periprosthetic fracture,” and “hip replacement or arthroplasty.” Meta-analysis of the clinical outcomes of HA and subgroup analysis based on the factors that were implicated in FPFs was performed. Results Sixteen studies were included (sample size: 599,551 HA patients, 4253 FPFs, incidence 0.71%). Risk factors statistically associated with increased incidence of FPFs were female gender (+ 40%), previous revision arthroplasty surgery (× 3 times), and the presence of rheumatoid arthritis (× 2.1 times), while osteoarthritis (− 57%), cement application (− 59%), and insertion of Biomet (− 68%) or Thompson’s prosthesis (− 75%) were correlated with low prevalence of FPFs. Obesity, cardiac diseases, advanced age, bad general health (ASA grade ≥ 3), and use of Exeter or Lubinus prosthesis were not linked to the appearance of FPFs. Conclusion This meta-analysis suggested that female gender, rheumatoid arthritis, and revision arthroplasty are major risk factors for the development of FPFs after a HA. In those patients, frequent follow-ups should be planned. Further prospective studies are necessary to clarify all the risk factors contributing to the appearance of FPFs after HA.

Risk Factors for Salmonella and Hygiene Indicators in the 10 Largest Belgian Pig Slaughterhouses

2008 ◽  
Vol 71 (7) ◽  
pp. 1320-1329 ◽  
Author(s):  
L. DELHALLE ◽  
L. DE SADELEER ◽  
K. BOLLAERTS ◽  
F. FARNIR ◽  
C. SAEGERMAN ◽  
...  
Keyword(s):  
Risk Factors ◽  
Mixed Model ◽  
Linear Mixed Model ◽  
Univariate Analysis ◽  
Random Effect ◽  
Mixed Linear Model ◽  
Mixed Regression ◽  
Potential Risk Factors ◽  
Pig Carcasses ◽  
Cleaning And Disinfection

A survey was conducted to collect data on Salmonella prevalence, Escherichia coli counts (ECCs), and aerobic bacteria colony counts (ACCs) on pig carcasses after chilling at the 10 largest Belgian pig slaughterhouses during 2000 through 2004. Potential risk factors of contamination associated with production parameters, technical descriptions of the installations, and cleaning and disinfection methods were assessed during investigations in the slaughterhouses. These variables were used first in a univariate analysis and then were extended to a multivariate analysis with a logistic mixed regression model for Salmonella and a linear mixed model for ECCs and ACCs with slaughterhouses as the random effect. The results indicated high variability concerning Salmonella contamination among the 10 slaughterhouses, with prevalence ranging from 2.6 to 34.3% according to the area of origin. The median ECC and median ACC ranged from −0.43 to 1.11 log CFU/cm2 and from 2.37 to 3.65 log CFU/cm2, respectively. The results of the logistic and linear regressions revealed that some working practices such as scalding with steam, second flaming after polishing, and complete cleaning and disinfection of the splitting machine several times a day were beneficial for reducing Salmonella prevalence, ECCs, and ACCs. Changing the carcass hooks just before chilling, using water as the cleaning method, and a higher frequency of disinfection of the lairage seemed to be protective against E. coli in the multivariate mixed linear model. The monitoring of critical points, slaughterhouse equipment, good slaughtering practices, and effective washing and disinfection are the keys to obtaining good microbiological results.

scholarly journals Clinical Risk Factors for Long-term Hospital Stay in Common Patients with coronavirus disease 2019(COVID-19)

2020 ◽  
Author(s):  
Wei Lu ◽  
Junjie Fang ◽  
Bin Chen ◽  
Dan Wu ◽  
Chunyao Yu ◽  
...  
Keyword(s):  
Risk Factors ◽  
Hospital Stay ◽  
Potential Risk ◽  
Clinical Laboratory ◽  
Short Term ◽  
Factors Associated ◽  
Regression Methods ◽  
Potential Risk Factors ◽  
Multivariable Regression

Abstract Background This study aimed to investigate the potential risk factors associated with hospital stay in mild patients with COVID-19. Methods A total of 109 laboratory-confirmed COVID patients with initial common subtype diseased by real-time RT-PCR that meet discharge standards were retrospectively included from January 16 to March 15 of 2020. Baseline demographic, clinical, laboratory examination was extracted from electronic medical records at the first day of admission and compared between short-term hospital stay and long-term hospital stay. Univariable and multivariable logistic regression methods were used to explore the risk factors associated with hospital stay. Results Of 109 COVID-19 patients, 61 patients were short-term stay (≤ 10 days) and 48 patients were long-term stay (> 10 days). The average age of patients in short-term stay were younger than those long-term stay(P = 0.01). Hypertension was the most common comorbidity (34%, 21/61), followed by diabetes (15%,9/61) and Cardiopathy (8%, 5/61). Fever and cough were the typical clinical manifestation in two group. Decreased WBC, Hemoglobin and increased Monocyte, MLR (Monocyte Lymphocyte ratio) and Hypersensitive CRP showed a long-term stay (all P < 0.05). The treatment of Resochin and Human immunoglobulin had a shorter hospital stay. Multivariable regression showed that MLR and CRP on admission were risk factors for predicting the hospital stay, with the HR (hazard ratio 2.03, 1.02–5.39; P = 0.022) and (1.32,1.05–3.24, P = 0.045) respectively. Conclusions The potential risk factors of MLR and CRP may help clinicians to predict the hospital stay of COVID-19 patients.

Different Perceptions of Factors Affecting the Financial Sustainability in Public Administrations

2018 ◽  
pp. 1-30
Author(s):  
Manuel Pedro Rodríguez Bolívar ◽  
María Deseada López Subires
Keyword(s):  
Risk Factors ◽  
Public Finance ◽  
Personal Characteristics ◽  
Educational Background ◽  
Influential Factors ◽  
Financial Sustainability ◽  
Factors Affecting ◽  
The Public ◽  
Potential Risk Factors ◽  
Research Findings

With the public finance crisis, the analysis of financial sustainability in governments, its influential factors, and the examination of politicians' perceptions about them have become relevant. In fact, it could be necessary to know whether politicians perceive as drivers or risk factors of financial sustainability those variables that prior research has identified with empirical findings. This chapter seeks to identify whether politicians are aware of influential factors previously identified by prior research for financial sustainability and whether personal characteristics of politicians (age, gender, or educational background) could influence this perception. So, an e-survey targeting politicians was conducted in sample of Spanish municipalities to capture their perceptions on potential risk factors and drivers, comparing this result with the findings obtained by prior research. Findings of this chapter indicate that there are different perceptions of politicians about drivers and risk factors among respondents according to their age, gender, and educational background.

scholarly journals A comprehensive evaluation of early potential risk factors for disease aggravation in patients with COVID-19

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Qiang Tang ◽  
Yanwei Liu ◽  
Yingfeng Fu ◽  
Ziyang Di ◽  
Kailiang Xu ◽  
...  
Keyword(s):  
Risk Factors ◽  
Regression Analysis ◽  
Serum Ferritin ◽  
Potential Risk ◽  
Comprehensive Evaluation ◽  
Organ Damage ◽  
Kaplan Meier ◽  
Public Crisis ◽  
Potential Risk Factors ◽  
Multivariable Regression

AbstractThe 2019 Coronavirus Disease (COVID-19) has become an unprecedented public crisis. We retrospectively investigated the clinical data of 197 COVID-19 patients and identified 88 patients as disease aggravation cases. Compared with patients without disease aggravation, the aggravation cases had more comorbidities, including hypertension (25.9%) and diabetes (20.8%), and presented with dyspnoea (23.4%), neutrophilia (31.5%), and lymphocytopenia (46.7%). These patients were more prone to develop organ damage in liver, kidney, and heart (P < 0.05). A multivariable regression analysis showed that advanced age, comorbidities, dyspnea, lymphopenia, and elevated levels of Fbg, CTnI, IL-6, and serum ferritin were significant predictors of disease aggravation. Further, we performed a Kaplan–Meier analysis to evaluate the prognosis of COVID-19 patients, which suggested that 64.9% of the patients had not experienced ICU transfers and survival from the hospital.

scholarly journals AN AHP BASED PRIORITIZATION MODEL FOR RISK EVALUATION FACTORS IN THE AUTOMOTIVE INDUSTRY

2018 ◽  
Vol 10 (1) ◽  
Author(s):  
Ilker Topcu ◽  
Berna Unver ◽  
Mine Isik ◽  
Ozgur Kabak
Keyword(s):  
Risk Factors ◽  
Automobile Industry ◽  
Manufacturing Process ◽  
Mixed Model ◽  
Product Variety ◽  
Production Quality ◽  
Assembly Lines ◽  
Analytic Hierarchy ◽  
Automotive Manufacturing ◽  
Potential Risk Factors

Due to product variety and modeling structure, the automotive manufacturing process requires state-of-the art production methods that cause a high complexity level in operations which assembly operators work in a mixed-assembly environment. To maintain a competitive advantage, companies should take a different approach that considers the methodologies which ensure excellence in operations. This study aims to identify and prioritize potential risk factors that cause errors and failures by applying the Analytic Hierarchy Process to improve the production quality in a manufacturing process of mixed model assembly lines in the automobile industry. Thus, numerous risk factors under three main categories including human-focused, design and process-driven are discussed in this work. The most important contribution of this study is the application of this methodology to find and rank the risk factors based on their importance in a world-leading automotive company in Turkey.

scholarly journals Predictors of Failed Intrauterine Balloon Tamponade in the Management of Severe Postpartum Hemorrhage

2021 ◽  
Vol 8 ◽  
Author(s):  
Congcong Liu ◽  
Jinsong Gao ◽  
Juntao Liu ◽  
Xietong Wang ◽  
Jing He ◽  
...  
Keyword(s):  
Risk Factors ◽  
Postpartum Hemorrhage ◽  
Logistic Models ◽  
Multiple Gestation ◽  
Lasso Regression ◽  
Factors Affecting ◽  
Balloon Tamponade ◽  
Estimated Blood Loss ◽  
Potential Risk Factors ◽  
Associated Risk Factors

To identify the factors predicting intrauterine balloon tamponade (IUBT) failure for severe postpartum hemorrhage (PPH) after delivery, we conducted a retrospective cohort study of women who underwent IUBT for severe PPH after delivery from October 1, 2016 until September 30, 2017. The failure of IUBT was defined as the need of additional surgical procedures or uterine embolization. A total of 99,650 deliveries occurred during the study period. Among the patients, 106 cases of severe PPH were managed with IUBT, and the global success rate was 70.8% (75/106). Least absolute shrinkage and selection operator (LASSO) regression was performed to select the potential risk factors predicting IUBT failure. The associated risk factors—obesity, multiple gestation, cesarean delivery, estimated blood loss (EBL), and placenta accreta spectrum (PAS)—were included in multivariate logistic models. Ultimately, these models identified multiple gestation, EBL, and PAS as independent risk factors for IUBT failure. In conclusion, IUBT is an effective method for severe PPH. The presence of factors affecting IUBT failure should be recognized early, and other modalities of management should be anticipated.

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