Interhospital variation in mortality among patients with systemic lupus erythematosus and sepsis in the USA

Abstract Objective To determine whether the risk of mortality in patients with SLE hospitalized with sepsis varies among hospitals in the USA. Methods We used the National Inpatient Sample (2002–2011) to obtain national population-based data on outcomes for adults with SLE admitted with sepsis, and compared it with that for patients without SLE admitted with sepsis at the same hospital. We computed expected mortality based on patient demographic characteristics, comorbidities and major organ dysfunction, and calculated observed/expected (O/E) mortality ratios separately for patients with SLE and without SLE for each hospital. We then computed the ratio of these O/E ratios within hospitals to assess relative SLE mortality. We considered hospitals with a risk ratio (RR) of ⩾2.0 as having high relative SLE mortality. Results Among 424 hospitals that treated a total of 4024 patients with SLE and sepsis, the risk of in-hospital mortality varied from 0% to 60% (median 11.1%). The RR ranged from 0 to 9.75, with a median of 0.84, indicating that O/E mortality was similar in patients with and without SLE at the average hospital. Sixty-one hospitals (14.4%) had a RR of ⩾2.0, indicating higher mortality among patients with SLE. Hospitals that on average treated ⩾3.9 patients with SLE and sepsis annually were less likely to have a RR of ⩾2.0 than hospitals that treated fewer patients (10% vs 17%; P = 0.004). Conclusion Mortality among patients with SLE and sepsis varied widely between hospitals, and was lower at hospitals that treated more of these patients.

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193-LB: Diabetes Mellitus Does Not Impact Negatively on Outcomes of Hospitalizations Primarily for Systemic Lupus Erythematosus (SLE): An Analysis of the National Inpatient Sample Database

Diabetes ◽

10.2337/db20-193-lb ◽

2020 ◽

Vol 69 (Supplement 1) ◽

pp. 193-LB

Author(s):

EHIZOGIE EDIGIN ◽

HAFEEZ SHAKA ◽

JING XU ◽

SARA ELIZABETH T. YAP ◽

MARIA ELENA PADILLA SORTO

Keyword(s):

Diabetes Mellitus ◽

Systemic Lupus Erythematosus ◽

Lupus Erythematosus ◽

National Inpatient Sample ◽

Systemic Lupus

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Faculty Opinions recommendation of Infection-related hospitalization and risk of end-stage renal disease in patients with systemic lupus erythematosus: a nationwide population-based study.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.727142853.793526813 ◽

2016 ◽

Author(s):

Luis Ruilope ◽

Enrique Morales

Keyword(s):

Systemic Lupus Erythematosus ◽

Renal Disease ◽

Lupus Erythematosus ◽

End Stage Renal Disease ◽

Population Based ◽

Systemic Lupus ◽

Population Based Study ◽

Stage Renal Disease ◽

End Stage

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The prevalence and incidence of systemic lupus erythematosus in Taiwan: a nationwide population-based study

Scientific Reports ◽

10.1038/s41598-021-84957-5 ◽

2021 ◽

Vol 11 (1) ◽

Author(s):

Pui-Ying Leong ◽

Jing-Yang Huang ◽

Jeng-Yuan Chiou ◽

Yi-Chiao Bai ◽

James Cheng-Chung Wei

Keyword(s):

Systemic Lupus Erythematosus ◽

Relative Risk ◽

Incidence Rate ◽

Rural Area ◽

Lupus Erythematosus ◽

The Elderly ◽

Income Group ◽

Population Based ◽

Systemic Lupus ◽

Male Population

AbstractTo estimate the prevalence and incidence rate of systemic lupus erythematosus (SLE) in Taiwan by using a population-based longitudinal database from 2001 to 2011. We conducted a longitudinal Health Insurance Database (LHID) containing 1,000,000 beneficiaries’ records for calculation of prevalence and incidence rate of SLE from 2001–2011. The overall prevalence of SLE in Taiwan in 2011 is 8.11 per 10,000 people with 14.3 per 10,000 people in female and 1.62 per 10,000 people in male. The overall incidence rate of SLE is 0.74–1 per 10,000 person-years with 1.09–1.76 per 10,000 person-years in female and 0.12–0.25 per 10,000 person-years in male. The highest prevalence rate was observed at 40–49 age group in females. There were no significant differences in the overall prevalence among the urban, suburban and rural area in Taiwan while the relative risk is higher in male population living in rural area (RR 1.36, 95% C.I. 1.03–1.79, p = 0.0303). The highest income group has a lower relative risk for the prevalence of SLE (RR 0.83, 95% C.I. 0.71–0.97, p = 0.0197). The incidence rate of SLE in male in the rural area is also higher than the urban area (RR 2.34, 95% C.I. 1.3–4.22, p = 0.0046). Our study covers the longest period among the nation-wide population studies of SLE in Taiwan. The prevalence was increasing especially in the elderly.

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Adult systemic lupus erythematosus in Egypt: The nation-wide spectrum of 3661 patients and world-wide standpoint

Lupus ◽

10.1177/09612033211014253 ◽

2021 ◽

pp. 096120332110142

Author(s):

Tamer A Gheita ◽

Rasha Abdel Noor ◽

Esam Abualfadl ◽

Osama S Abousehly ◽

Iman I El-Gazzar ◽

...

Keyword(s):

Systemic Lupus Erythematosus ◽

Lupus Erythematosus ◽

Age Of Onset ◽

Wide Spectrum ◽

Age At Onset ◽

Disease Onset ◽

Clinical Manifestations ◽

Population Based ◽

Systemic Lupus ◽

Cross Sectional

Objective The aim of this study was to present the epidemiology, clinical manifestations and treatment pattern of systemic lupus erythematosus (SLE) in Egyptian patients over the country and compare the findings to large cohorts worldwide. Objectives were extended to focus on the age at onset and gender driven influence on the disease characteristics. Patients and method This population-based, multicenter, cross-sectional study included 3661 adult SLE patients from Egyptian rheumatology departments across the nation. Demographic, clinical, and therapeutic data were assessed for all patients. Results The study included 3661 patients; 3296 females and 365 males (9.03:1) and the median age was 30 years (17–79 years), disease duration 4 years (0–75 years) while the median age at disease onset was 25 years (4–75 years). The overall estimated prevalence of adult SLE in Egypt was 6.1/100,000 population (1.2/100,000 males and 11.3/100,000 females).There were 316 (8.6%) juvenile-onset (Jo-SLE) and 3345 adult-onset (Ao-SLE). Age at onset was highest in South and lowest in Cairo (p < 0.0001). Conclusion SLE in Egypt had a wide variety of clinical and immunological manifestations, with some similarities with that in other nations and differences within the same country. The clinical characteristics, autoantibodies and comorbidities are comparable between Ao-SLE and Jo-SLE. The frequency of various clinical and immunological manifestations varied between gender. Additional studies are needed to determine the underlying factors contributing to gender and age of onset differences.

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