scholarly journals Combined Effects of Dietary Phytoestrogen and Synthetic Endocrine-Active Compound on Reproductive Development in Sprague-Dawley Rats: Genistein and Methoxychlor

2002 ◽  
Vol 66 (1) ◽  
pp. 91-104 ◽  
Author(s):  
L. You
Keyword(s):  
Active Compound ◽  
Reproductive Development ◽  
Combined Effects ◽  
Sprague Dawley ◽  
Sprague Dawley Rats

Combined effects of the mycotoxins aflatoxin B1 and cyclopiazonic acid on Sprague-Dawley rats

1987 ◽  
Vol 25 (11) ◽  
pp. 837-842 ◽  
Author(s):  
R.E. Morrissey ◽  
W.P. Norred ◽  
D.M. Hinton ◽  
R.J. Cole ◽  
J.W. Dorner
Keyword(s):  
Aflatoxin B1 ◽  
Cyclopiazonic Acid ◽  
Combined Effects ◽  
Sprague Dawley ◽  
Sprague Dawley Rats

Independent and Combined Effects of Bisphenol A and Diethylhexyl Phthalate on Gestational Outcomes and Offspring Development in Sprague‐Dawley Rats

2020 ◽  
Vol 34 (S1) ◽  
pp. 1-1
Author(s):  
Josephine Bou Dagher ◽  
Elyssa Campbell ◽  
Amrita Kaimal ◽  
Coral Hahn-Townsend ◽  
Maryam Hazim Al Mansi ◽  
...  
Keyword(s):  
Bisphenol A ◽  
Combined Effects ◽  
Sprague Dawley ◽  
Diethylhexyl Phthalate ◽  
Offspring Development ◽  
Sprague Dawley Rats

Independent and combined effects of Bisphenol A and Diethylhexyl Phthalate on gestational outcomes and offspring development in Sprague-Dawley rats

Chemosphere ◽  
2021 ◽  
Vol 263 ◽  
pp. 128307
Author(s):  
Josephine Bou Dagher ◽  
Coral K. Hahn-Townsend ◽  
Amrita Kaimal ◽  
Maryam Al Mansi ◽  
Joseph E. Henriquez ◽  
...  
Keyword(s):  
Bisphenol A ◽  
Combined Effects ◽  
Sprague Dawley ◽  
Diethylhexyl Phthalate ◽  
Offspring Development ◽  
Sprague Dawley Rats

scholarly journals Dietary Exposure to Oxidized Frying Oil from Fetus to Adulthood Suppresses Male Reproductive Development by Altering Testicular Cholesterol and Testosterone Homeostasis in Sprague Dawley Rats

2020 ◽  
Vol 150 (7) ◽  
pp. 1713-1721
Author(s):  
Hai-Ping Wu ◽  
Yu-Shun Lin ◽  
Chi-Fen Chang ◽  
Shui-Yuan Lu ◽  
Pei-Min Chao
Keyword(s):  
Weight Loss ◽  
Body Weight ◽  
Soybean Oil ◽  
Body Weight Loss ◽  
Reproductive Development ◽  
Frying Oil ◽  
Female Rats ◽  
Male Rats ◽  
Sprague Dawley ◽  
Sprague Dawley Rats

ABSTRACT Background Dietary frying oil may have endocrine-disrupting effects, as a feminization effect was observed in cohorts of C57BL/6J male mice fetuses from dams consuming oxidized frying oil (OFO) during pregnancy. Objective The aim of present study was to test the hypothesis that OFO is an anti-androgen. Methods In experiment 1, male progeny of Sprague Dawley female rats fed fresh oil or an OFO diet (10 g fat/100 g, from fresh or 24-h–fried soybean oil; [control diet (C) and OFO groups, respectively] from midgestation through lactation were studied. Pups were weaned at 3 wk of age and then consumed their mothers’ diet until 9 wk of age. In addition, a group of dams and pups that consumed a high-fat diet (HF; 10 g fried and 20 g fresh soybean oil/100 g) was included to counteract body-weight loss associated with OFO ingestion. Indices of male reproductive development and testosterone homeostasis were measured. In experiment 2, male rats were allocated to C and OFO groups (treated as above) and indices of male fertility compared at 9–10 wk of age. Results In experiment 1, final body weights of the HF group were lower (17%) than the C group but higher (14%) than the OFO group (P < 0.0001 for each). In addition to abnormalities in seminiferous tubules, HF and OFO groups did not differ from one another, but, compared with the C group, had delayed preputial separation (4.9 d) and reductions in serum testosterone concentrations (17–74%), anogenital distance (8–20%), weights of androgen-dependent tissues (8–30%), testicular testosterone and cholesterol concentrations (30–40%), and mRNA levels of genes involved in steroidogenesis and cholesterol homeostasis (30–70%). In experiment 2, OFO-exposed males had 20% lower sperm motility (P < 0.05); however, when mated to normal females, pregnancy rates and litter sizes did not differ between OFO and C groups. Conclusions The anti-androgenic effect of OFO in Sprague Dawley rats was attributed to decreased testicular concentrations of cholesterol (testosterone precursor) and not body-weight loss.

scholarly journals Histologic Features of Prepubertal and Pubertal Reproductive Development in Female Sprague-Dawley Rats

2013 ◽  
Vol 42 (2) ◽  
pp. 403-413 ◽  
Author(s):  
Catherine A. Picut ◽  
Amera K. Remick ◽  
Midori G. Asakawa ◽  
Michelle L. Simons ◽  
George A. Parker
Keyword(s):  
Reproductive Development ◽  
Sprague Dawley ◽  
Sprague Dawley Rats
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