Cyclic Adenosine Monophosphate-Dependent Protein Kinases of Human Seminal Plasma: Origin and Characteristics of Multiple Forms

The human promyelocytic leukemia cell line HL-60 is induced to differentiate along a myelocytic pathway by dibutyryl cyclic adenosine monophosphate (dbcAMP). Other cAMP analogs are ineffective as inducing agents. The effect of these compounds on expression of c-myc was investigated using a DNA probe for c-myc to detect RNA transcripts. The dose response and time to commitment for reduction in c-myc expression with dbcAMP was similar to the findings for phenotypic changes. Bromo- cyclic AMP and butyrate alone caused no changes in c-myc expression in 24 hours, but demonstrated dramatic synergism together, suggesting that butyrate contributes in part to the effects of dbcAMP. Evidence for mechanisms of action of cAMP other than activation of the cAMP- dependent protein kinase is reviewed.

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Molecular Cloning, Complementary Deoxyribonucleic Acid Structure and Predicted Full-Length Amino Acid Sequence of the Hormone-lnducible Regulatory Subunit of 3′-5′-Cyclic Adenosine Monophosphate-Dependent Protein Kinase from Human Testis

Molecular Endocrinology ◽

10.1210/mend-2-12-1364 ◽

1988 ◽

Vol 2 (12) ◽

pp. 1364-1373 ◽

Cited By ~ 87

Author(s):

Finn Olav Levy ◽

Ole Øyen ◽

Mårten Sandberg ◽

Kjetil Taskén ◽

Winnie Eskild ◽

...

Keyword(s):

Amino Acid ◽

Deoxyribonucleic Acid ◽

Cyclic Adenosine Monophosphate ◽

Adenosine Monophosphate ◽

Regulatory Subunit ◽

Human Testis ◽

Dependent Protein Kinase ◽

Dependent Protein ◽

Complementary Deoxyribonucleic Acid ◽

Acid Structure

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Role of the Cyclic Adenosine Monophosphate-Dependent Protein Kinase in the Control of Meiotic Resumption in Bovine Oocytes Cultured with Thecal Cell Monolayers1

Biology of Reproduction ◽

10.1095/biolreprod56.6.1363 ◽

1997 ◽

Vol 56 (6) ◽

pp. 1363-1369 ◽

Cited By ~ 20

Author(s):

François J. Richard ◽

Michel A. Fortier ◽

Marc-André Sirard

Keyword(s):

Protein Kinase ◽

Cyclic Adenosine Monophosphate ◽

Adenosine Monophosphate ◽

Thecal Cell ◽

Dependent Protein Kinase ◽

Dependent Protein ◽

Bovine Oocytes

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Microglia control the glycinergic but not the GABAergic synapses via prostaglandin E2 in the spinal cord

The Journal of Cell Biology ◽

10.1083/jcb.201607048 ◽

2017 ◽

Vol 216 (9) ◽

pp. 2979-2989 ◽

Cited By ~ 26

Author(s):

Yasmine Cantaut-Belarif ◽

Myriam Antri ◽

Rocco Pizzarelli ◽

Sabrina Colasse ◽

Ilaria Vaccari ◽

...

Keyword(s):

Prostaglandin E2 ◽

Cyclic Adenosine Monophosphate ◽

Adenosine Monophosphate ◽

Brain Diseases ◽

Excitatory Synapses ◽

Diffusion Dynamics ◽

Gabaergic Synapses ◽

Dependent Protein ◽

Activity Dependent ◽

Early Features

Microglia control excitatory synapses, but their role in inhibitory neurotransmission has been less well characterized. Herein, we show that microglia control the strength of glycinergic but not GABAergic synapses via modulation of the diffusion dynamics and synaptic trapping of glycine (GlyR) but not GABAA receptors. We further demonstrate that microglia regulate the activity-dependent plasticity of glycinergic synapses by tuning the GlyR diffusion trap. This microglia–synapse cross talk requires production of prostaglandin E2 by microglia, leading to the activation of neuronal EP2 receptors and cyclic adenosine monophosphate–dependent protein kinase. Thus, we now provide a link between microglial activation and synaptic dysfunctions, which are common early features of many brain diseases.

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Dibutyryl cyclic adenosine monophosphate reduces expression of c-myc during HL-60 differentiation

Blood ◽

10.1182/blood.v68.2.412.412 ◽

1986 ◽

Vol 68 (2) ◽

pp. 412-416 ◽

Cited By ~ 29

Author(s):

SS Jr McCachren ◽

J Nichols ◽

RE Kaufman ◽

JE Niedel

Keyword(s):

Leukemia Cell ◽

Cyclic Adenosine Monophosphate ◽

Adenosine Monophosphate ◽

Mechanisms Of Action ◽

Promyelocytic Leukemia ◽

Leukemia Cell Line ◽

Dependent Protein Kinase ◽

Rna Transcripts ◽

Dependent Protein ◽

Promyelocytic Leukemia Cell Line

Abstract The human promyelocytic leukemia cell line HL-60 is induced to differentiate along a myelocytic pathway by dibutyryl cyclic adenosine monophosphate (dbcAMP). Other cAMP analogs are ineffective as inducing agents. The effect of these compounds on expression of c-myc was investigated using a DNA probe for c-myc to detect RNA transcripts. The dose response and time to commitment for reduction in c-myc expression with dbcAMP was similar to the findings for phenotypic changes. Bromo- cyclic AMP and butyrate alone caused no changes in c-myc expression in 24 hours, but demonstrated dramatic synergism together, suggesting that butyrate contributes in part to the effects of dbcAMP. Evidence for mechanisms of action of cAMP other than activation of the cAMP- dependent protein kinase is reviewed.

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