scholarly journals A RNAi screening to identify novel targets in cisplatin‐resistant ovarian cancer

2021 ◽  
Vol 35 (S1) ◽  
Author(s):  
Ricardo Noriega ◽  
Josué Pérez ◽  
Pablo Vivas
Keyword(s):  
Ovarian Cancer ◽  
Rnai Screening ◽  
Novel Targets

scholarly journals Local estrogen metabolism in epithelial ovarian cancer suggests novel targets for therapy

2015 ◽  
Vol 150 ◽  
pp. 54-63 ◽  
Author(s):  
Xia Ren ◽  
Xuan Wu ◽  
Stephen G. Hillier ◽  
K. Scott Fegan ◽  
Hilary O.D. Critchley ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Epithelial Ovarian Cancer ◽  
Estrogen Metabolism ◽  
Novel Targets

RNAi screening of the kinome identifies modulators of cisplatin response in ovarian cancer cells

2010 ◽  
Vol 118 (3) ◽  
pp. 220-227 ◽  
Author(s):  
Shilpi Arora ◽  
Kristen M. Bisanz ◽  
Lourdes A. Peralta ◽  
Gargi D. Basu ◽  
Ashish Choudhary ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Cancer Cells ◽  
Ovarian Cancer Cells ◽  
Rnai Screening

scholarly journals Extracellular Vesicles and Ovarian Cancer

2021 ◽  
Author(s):  
Diego Aviles ◽  
David Warshal ◽  
Lauren Krill ◽  
Olga Ostrovsky
Keyword(s):  
Ovarian Cancer ◽  
Cancer Cells ◽  
Extracellular Vesicles ◽  
Immune Modulation ◽  
Treatment Modalities ◽  
Early Screening ◽  
Novel Targets ◽  
Immunomodulatory Therapies ◽  
Improve Clinical Outcome ◽  
Screening And Diagnosis

Extracellular vesicles (EVs) are a varied group of cell-derived, microscopic, fluid-filled pouches released from cells into neighboring microenvironments that are quickly gaining recognition as a potentially powerful tool against epithelial ovarian cancer (EOC). Recent studies show that not only do EVs play an integral part in the development of cancer through intercellular communication, cell survival, and immune modulation but also may assist with early diagnosis and improved treatments. EOC currently has few effective screening options for early detection of this disease; and, therefore, it is detected at an advanced stage where it is more likely to recur, develop chemoresistance, and ultimately become fatal. Newer research has evaluated EVs as biomarkers for early screening and diagnosis and as novel targets for treatment of EOC. Moreover, EVs are possible targets for novel immunomodulatory therapies to directly target cancer cells or make cancer cells more susceptible to other treatment modalities. Therefore, EVs present an exciting, promising approach which may improve clinical outcome for EOC patients.

Other New Targets

2009 ◽  
Vol 19 (Suppl 2) ◽  
pp. S49-S54 ◽  
Author(s):  
Helen J. Mackay ◽  
Amit M. Oza
Keyword(s):  
Ovarian Cancer ◽  
Epithelial Ovarian Cancer ◽  
Cancer Biology ◽  
Trial Design ◽  
Diagnostic Techniques ◽  
Antiangiogenic Agents ◽  
Targeted Agents ◽  
Recent Developments ◽  
Advanced Epithelial Ovarian Cancer ◽  
Novel Targets

Despite improvements in surgical and diagnostic techniques, the outcome for women with advanced epithelial ovarian cancer remains poor. Recent developments in the understanding of cancer biology have led to an explosion in clinical trials using targeted agents. In women with epithelial ovarian cancer, antiangiogenic agents have led the field. There are, however, other novel targets and agents undergoing evaluation. This review focuses on some of these newer approaches to targeted therapy highlighting the importance of trial design and incorporation of biomarkers as we move forward into the era of personalized medicine.

Ovarian cancer: Ion channel and aquaporin expression as novel targets of clinical potential

2013 ◽  
Vol 49 (10) ◽  
pp. 2331-2344 ◽  
Author(s):  
Julia Frede ◽  
Scott P. Fraser ◽  
Gülten Oskay-Özcelik ◽  
Yeosun Hong ◽  
E. Ioana Braicu ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Ion Channel ◽  
Novel Targets ◽  
Clinical Potential

Abstract LB-214: Rac1 and Cdc42 GTPases as novel targets in ovarian cancer

2011 ◽  
Author(s):  
Angela Wandinger-Ness ◽  
S. Ray Kenney ◽  
Jacob Agola ◽  
Joshua Roxby ◽  
Zurab Surviladze ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Novel Targets

Abstract IA3: In tumor screening for novel targets in papillary serous ovarian cancer

2013 ◽  
Author(s):  
Maria Giuseppina Baratta ◽  
Maria Giuseppina Baratta ◽  
Joyce Liu ◽  
Joyce Liu ◽  
Yaara Zwang ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Serous Ovarian Cancer ◽  
Novel Targets

Abstract A57: Identification of novel targets for ovarian cancer treatment

2020 ◽  
Author(s):  
Ricardo Noriega ◽  
Jeyshka Reyes ◽  
Blanca Quiñones ◽  
Joseline Serrano ◽  
Pablo Vivas ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Cancer Treatment ◽  
Novel Targets
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