scholarly journals Atrial Natriuretic Peptide Stimulates Rat Pancreatic Beta‐Cell Growth

2009 ◽  
Vol 23 (S1) ◽  
Author(s):  
Hui You ◽  
Suzanne G Laychock
Keyword(s):  
Cell Growth ◽  
Atrial Natriuretic Peptide ◽  
Beta Cell ◽  
Natriuretic Peptide ◽  
Pancreatic Beta Cell ◽  
Beta Cell Growth ◽  
Atrial Natriuretic

Effect of epiregulin on pancreatic beta cell growth and insulin secretion

2005 ◽  
Vol 23 (4) ◽  
pp. 285-293 ◽  
Author(s):  
Emmanuelle Kuntz ◽  
Christophe Broca ◽  
Toshi Komurasaki ◽  
Marie-Christine Kaltenbacher ◽  
René Gross ◽  
...  
Keyword(s):  
Insulin Secretion ◽  
Cell Growth ◽  
Beta Cell ◽  
Pancreatic Beta Cell ◽  
Beta Cell Growth

HCaRG is a novel regulator of renal epithelial cell growth and differentiation causing G2M arrest

2003 ◽  
Vol 284 (4) ◽  
pp. F753-F762 ◽  
Author(s):  
Alison M. Devlin ◽  
Nicolas Solban ◽  
Sandra Tremblay ◽  
Jolanta Gutkowska ◽  
Walter Schürch ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Cell Growth ◽  
Epithelial Cell ◽  
Atrial Natriuretic Peptide ◽  
Cell Size ◽  
Natriuretic Peptide ◽  
Renal Epithelial Cell ◽  
Hek 293 ◽  
Cell Growth And Differentiation ◽  
Atrial Natriuretic

We recently identified a novel calcium-regulated gene, HCaRG, that is highly expressed in the kidney and maps to a chromosomal locus determining kidney weight in rats. The mRNA levels of HCaRG negatively correlate with the proliferative status of the kidney cells. To investigate its role in renal epithelial cellular growth directly, we studied the human embryonic kidney cell line (HEK-293) stably transfected with either plasmid alone or plasmid containing rat HCaRG. [3H]thymidine incorporation was significantly lower in HCaRG clones. Although HCaRG clones exhibited some enhanced susceptibility to cell death, this was not the primary mechanism of reduced proliferation. Cell cycle analysis revealed a G2M phase accumulation in HCaRG clones that was associated with upregulation of p21Cip1/WAF1 and downregulation of p27Kip1. HCaRG clones had a greater protein content, larger cell size, and released 4.5- to 8-fold more of an atrial natriuretic peptide-like immunoreactivity compared with controls. In addition, HCaRG clones demonstrated the presence of differentiated junctions and a lower incidence of mitotic figures. Genistein treatment of wild-type HEK-293 cells mimicked several phenotypic characteristics associated with HCaRGoverexpresssion, including increased cell size and increased release of atrial natriuretic peptide. Taken together, our results suggest that HCaRG is a regulator of renal epithelial cell growth and differentiation causing G2M cell cycle arrest.

scholarly journals A role for hepatocyte growth factor/scatter factor in fetal mesenchyme-induced pancreatic beta-cell growth.

Endocrinology ◽  
1996 ◽  
Vol 137 (7) ◽  
pp. 3131-3139 ◽  
Author(s):  
T Otonkoski ◽  
V Cirulli ◽  
M Beattie ◽  
M I Mally ◽  
G Soto ◽  
...  
Keyword(s):  
Growth Factor ◽  
Cell Growth ◽  
Hepatocyte Growth Factor ◽  
Beta Cell ◽  
Pancreatic Beta Cell ◽  
Scatter Factor ◽  
Beta Cell Growth ◽  
Hepatocyte Growth
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