scholarly journals IGF1 prevents radiation‐induced salivary gland dysfunction which does not affect survival of head and neck tumors

2010 ◽  
Vol 24 (S1) ◽  
Author(s):  
Kerton R Victory ◽  
Kirsten H Limesand
Keyword(s):  
Salivary Gland ◽  
Head And Neck ◽  
Head And Neck Tumors ◽  
Salivary Gland Dysfunction ◽  
Neck Tumors ◽  
Radiation Induced

scholarly journals Review and Updates of Immunohistochemistry in Selected Salivary Gland and Head and Neck Tumors

2015 ◽  
Vol 139 (1) ◽  
pp. 55-66 ◽  
Author(s):  
Shaobo Zhu ◽  
Conrad Schuerch ◽  
Jennifer Hunt
Keyword(s):  
Differential Diagnosis ◽  
Salivary Gland ◽  
Literature Review ◽  
Head And Neck ◽  
Head And Neck Tumors ◽  
Data Sources ◽  
Diverse Group ◽  
Immunohistochemical Markers ◽  
Neck Tumors ◽  
Practice Experience

Context Immunohistochemistry is a useful tool for diagnosing salivary gland and head and neck tumors. Objective To review immunohistochemical markers, which can aid in the diagnosis of selected salivary gland and head and neck tumors. Data Sources Literature review and authors' personal practice experience. Conclusions Salivary gland and head and neck tumors include a large diverse group of tumors with complex and overlapping histologic features. Immunohistochemistry plays an important role in resolving the differential diagnosis of some salivary gland and head and neck tumors and can provide information for the prognosis of certain tumors.

Head and Neck Tumors in Children: Part II

2021 ◽  
Author(s):  
Joseph Lopez ◽  
Jason W. Yu ◽  
Salim Afshar
Keyword(s):  
Salivary Gland ◽  
Soft Tissue ◽  
Head And Neck ◽  
Mucoepidermoid Carcinoma ◽  
Salivary Gland Tumors ◽  
Head And Neck Tumors ◽  
Thyroglossal Duct ◽  
Neck Tumors ◽  
Adenoid Cystic ◽  
Thyroglossal Duct Cysts

The following chapter will focus on common soft tissue lesions one would encounter as pediatric head and neck tumors. The selected topics covered will be cholesteatoma, craniopharyngioma, encephalocele, teratomas, dermoid cysts and pilomatrixoma. Salivary gland tumors discussed are pleomorphic adenoma, mucoepidermoid carcinoma, adenoid cystic carcinoma and acinic cell carcinoma. Vascular anomalies are covered in another section.  Keywords: cholesteatoma, craniopharyngioma, encephalocele, teratomas, dermoid cysts, neuroblastoma, pilomatrixoma, thyroglossal duct cysts, salivary gland tumors

scholarly journals Integration of metabolomics and transcriptomics reveals convergent pathways driving radiation-induced salivary gland dysfunction

2021 ◽  
Author(s):  
Lauren Gayle Meeks ◽  
Diogo De Oliveira Pessoa ◽  
Jessica Anne Martinez ◽  
Kirsten H. Limesand ◽  
Megha Padi
Keyword(s):  
Salivary Gland ◽  
Energy Metabolism ◽  
Head And Neck ◽  
Salivary Glands ◽  
Metabolic Phenotype ◽  
Glutathione Metabolism ◽  
Metabolic Reaction ◽  
Salivary Gland Dysfunction ◽  
Damage Response ◽  
Radiation Induced

Radiation therapy for head and neck cancer causes damage to the surrounding salivary glands, resulting in salivary gland hypofunction and xerostomia. Current treatments do not provide lasting restoration of salivary gland function following radiation; therefore, a new mechanistic understanding of the radiation-induced damage response is necessary for identifying therapeutic targets. The purpose of the present study was to investigate the metabolic phenotype of radiation-induced damage in parotid salivary glands by integrating transcriptomic and metabolomic data. Integrated data were then analyzed to identify significant gene-metabolite interactions. Mice received a single 5 Gy dose of targeted head and neck radiation. Parotid tissue samples were collected 5 days following treatment for RNA sequencing and metabolomics analysis. Altered metabolites and transcripts significantly converged on a specific region in the metabolic reaction network. Both integrative pathway enrichment using rank-based statistics and network analysis highlighted significantly coordinated changes in glutathione metabolism, energy metabolism (TCA cycle and thermogenesis), peroxisomal lipid metabolism, and bile acid production with radiation. Integrated changes observed in energy metabolism suggest that radiation induces a mitochondrial dysfunction phenotype. These findings validated previous pathways involved in the radiation-damage response, such as altered energy metabolism, and identified robust signatures in salivary glands, such as reduced glutathione metabolism, that may be driving salivary gland dysfunction.

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