scholarly journals The potential interplay between energy metabolism and innate complement activation in amyotrophic lateral sclerosis

2020 ◽  
Vol 34 (6) ◽  
pp. 7225-7233
Author(s):  
Tanya S. McDonald ◽  
Pamela A. McCombe ◽  
Trent M. Woodruff ◽  
John D. Lee
Keyword(s):  
Amyotrophic Lateral Sclerosis ◽  
Energy Metabolism ◽  
Complement Activation ◽  
Lateral Sclerosis

scholarly journals The role of single-nucleotide variants of the energy metabolism-linked genes SIRT3, PPARGC1A and APOE in amyotrophic lateral sclerosis risk

2016 ◽  
Vol 91 (6) ◽  
pp. 301-309 ◽  
Author(s):  
Diego Albani ◽  
Elisabetta Pupillo ◽  
Elisa Bianchi ◽  
Armando Chierchia ◽  
Rosalba Martines ◽  
...  
Keyword(s):  
Amyotrophic Lateral Sclerosis ◽  
Energy Metabolism ◽  
Single Nucleotide Variants ◽  
Single Nucleotide ◽  
Lateral Sclerosis

Glutamate and glutathione interplay in a motor neuronal model of amyotrophic lateral sclerosis reveals altered energy metabolism

2011 ◽  
Vol 43 (2) ◽  
pp. 346-355 ◽  
Author(s):  
Giuseppina D'Alessandro ◽  
Eleonora Calcagno ◽  
Silvia Tartari ◽  
Milena Rizzardini ◽  
Roberto William Invernizzi ◽  
...  
Keyword(s):  
Amyotrophic Lateral Sclerosis ◽  
Energy Metabolism ◽  
Neuronal Model ◽  
Lateral Sclerosis

Energy metabolism in amyotrophic lateral sclerosis

2011 ◽  
Vol 10 (1) ◽  
pp. 75-82 ◽  
Author(s):  
Luc Dupuis ◽  
Pierre-François Pradat ◽  
Albert C Ludolph ◽  
Jean-Philippe Loeffler
Keyword(s):  
Amyotrophic Lateral Sclerosis ◽  
Energy Metabolism ◽  
Lateral Sclerosis

scholarly journals Existing and Emerging Metabolomic Tools for ALS Research

Genes ◽  
2019 ◽  
Vol 10 (12) ◽  
pp. 1011 ◽  
Author(s):  
Christine Germeys ◽  
Tijs Vandoorne ◽  
Valérie Bercier ◽  
Ludo Van Den Bosch
Keyword(s):  
Amyotrophic Lateral Sclerosis ◽  
Energy Metabolism ◽  
Motor Neurons ◽  
Therapeutic Strategies ◽  
Metabolic State ◽  
Advanced Technologies ◽  
Novel Therapeutic Strategies ◽  
Lateral Sclerosis ◽  
Novel Therapeutic

Growing evidence suggests that aberrant energy metabolism could play an important role in the pathogenesis of amyotrophic lateral sclerosis (ALS). Despite this, studies applying advanced technologies to investigate energy metabolism in ALS remain scarce. The rapidly growing field of metabolomics offers exciting new possibilities for ALS research. Here, we review existing and emerging metabolomic tools that could be used to further investigate the role of metabolism in ALS. A better understanding of the metabolic state of motor neurons and their surrounding cells could hopefully result in novel therapeutic strategies.

Innate and adaptive immunity in amyotrophic lateral sclerosis: Evidence of complement activation

2011 ◽  
Vol 42 (3) ◽  
pp. 211-220 ◽  
Author(s):  
M. Sta ◽  
R.M.R. Sylva-Steenland ◽  
M. Casula ◽  
J.M.B.V. de Jong ◽  
D. Troost ◽  
...  
Keyword(s):  
Amyotrophic Lateral Sclerosis ◽  
Adaptive Immunity ◽  
Complement Activation ◽  
Innate And Adaptive Immunity ◽  
Lateral Sclerosis

Paradox of amyotrophic lateral sclerosis and energy metabolism

2018 ◽  
Vol 89 (10) ◽  
pp. 1013-1014 ◽  
Author(s):  
Rebekah M Ahmed ◽  
Luc Dupuis ◽  
Matthew C Kiernan
Keyword(s):  
Amyotrophic Lateral Sclerosis ◽  
Energy Metabolism ◽  
Lateral Sclerosis
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