ANESTHETIC ACTION OF ETOMIDATE IS ENHANCED BY THE NO-SYNTHASE INHIBITOR NITRO-L-ARGININE-METHYL-ESTER (L-NAME)

1998 ◽  
Vol 89 (Supplement) ◽  
pp. 180A
Author(s):  
T. Krause ◽  
P. H. Tonner ◽  
J. Scholz ◽  
E. Suppe ◽  
J. Schulte Esch
Keyword(s):  
Methyl Ester ◽  
No Synthase ◽  
No Synthase Inhibitor ◽  
Anesthetic Action ◽  
Synthase Inhibitor

scholarly journals Role of Nitric Oxide in Regulating Cerebrocortical Oxygen Consumption and Blood Flow during Hypercapnia

1994 ◽  
Vol 14 (3) ◽  
pp. 503-509 ◽  
Author(s):  
Ildiko Horvath ◽  
Norbert T. Sandor ◽  
Zoltan Ruttner ◽  
Alan C. McLaughlin
Keyword(s):  
Nitric Oxide ◽  
Blood Flow ◽  
Oxygen Consumption ◽  
Methyl Ester ◽  
Superior Sagittal Sinus ◽  
No Synthase ◽  
Sagittal Sinus ◽  
No Synthase Inhibitor ◽  
Synthase Inhibitor

The effect of the nitric oxide (NO) synthase inhibitor Nω-nitro-l-arginine methyl ester (l-NAME) on the response of cerebrocortical oxygen consumption (CMRO2) and blood flow (CBF) to two levels of hypercapnia (Paco2 ∼ 60 mm Hg and Paco2 ∼ 90 mm Hg) was investigated in ketamine-anesthetized rats. CBF was calculated using the Kety–Schmidt approach and CMRO2 was calculated from the product of CBF and the arteriovenous (superior sagittal sinus) difference for oxygen. l-NAME treatment did not have a significant effect on either CMRO2 or CBE under normocapnic conditions but inhibited the hypercapnic increase of CMRO2 and the hypercapnic increase in CBF. These results suggest that NO plays a role in the response of CMRO2 and CBF during hypercapnia and are consistent with the suggestion that at least part of the increase in CBF observed during hypercapnia is coupled to an increase in CMRO2.

Relaxation induced by red wine polyphenolic compounds in rat pulmonary arteries: lack of inhibition by NO-synthase inhibitor

2008 ◽  
Vol 22 (1) ◽  
pp. 25-35 ◽  
Author(s):  
Véronique Leblais ◽  
Stéphanie Krisa ◽  
Josep Valls ◽  
Arnaud Courtois ◽  
Sabrina Abdelouhab ◽  
...  
Keyword(s):  
Red Wine ◽  
Pulmonary Arteries ◽  
Polyphenolic Compounds ◽  
No Synthase ◽  
No Synthase Inhibitor ◽  
Synthase Inhibitor

scholarly journals Erythropoietin Produces a Dual Effect on Carotid Body Chemoreception in Male Rats

2021 ◽  
Vol 12 ◽  
Author(s):  
Christian Arias-Reyes ◽  
Sofien Laouafa ◽  
Natalia Zubieta-DeUrioste ◽  
Vincent Joseph ◽  
Aida Bairam ◽  
...  
Keyword(s):  
Carotid Body ◽  
No Synthase ◽  
Male Rats ◽  
High Dose ◽  
No Production ◽  
Sprague Dawley ◽  
En Bloc ◽  
No Synthase Inhibitor ◽  
Sprague Dawley Rats ◽  
Synthase Inhibitor

Erythropoietin (EPO) regulates respiration under conditions of normoxia and hypoxia through interaction with the respiratory centers of the brainstem. Here we investigate the dose-dependent impact of EPO in the CB response to hypoxia and hypercapnia. We show, in isolated “en bloc” carotid body (CB) preparations containing the carotid sinus nerve (CSN) from adult male Sprague Dawley rats, that EPO acts as a stimulator of CSN activity in response to hypoxia at concentrations below 0.5 IU/ml. Under hypercapnic conditions, EPO did not influence the CSN response. EPO concentrations above 0.5 IU/ml decreased the response of the CSN to both hypoxia and hypercapnia, reaching complete inhibition at 2 IU/ml. The inhibitory action of high-dose EPO on the CSN activity might result from an increase in nitric oxide (NO) production. Accordingly, CB preparations were incubated with 2 IU/ml EPO and the unspecific NO synthase inhibitor (L-NAME), or the neuronal-specific NO synthase inhibitor (7NI). Both NO inhibitors fully restored the CSN activity in response to hypoxia and hypercapnia in presence of EPO. Our results show that EPO activates the CB response to hypoxia when its concentration does not exceed the threshold at which NO inhibitors masks EPO’s action.

Low protein diet exacerbates NO synthase inhibitor-induced hypertension in rats

1999 ◽  
Vol 3 (1) ◽  
pp. 34-40 ◽  
Author(s):  
H. Kumagai ◽  
Yoshiko Kikuchi ◽  
Noriko Kumeta ◽  
Masato Kimura ◽  
Toshio Sakai
Keyword(s):  
No Synthase ◽  
Protein Diet ◽  
Low Protein Diet ◽  
Low Protein ◽  
No Synthase Inhibitor ◽  
Induced Hypertension ◽  
Synthase Inhibitor
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