Perceived viral load, but not actual HIV-1-RNA load, is associated with sexual risk behaviour among HIV-infected homosexual men

AIDS ◽  
2004 ◽  
Vol 18 (14) ◽  
pp. 1943-1949 ◽  
Author(s):  
Ineke G Stolte ◽  
John BF de Wit ◽  
Arne van Eeden ◽  
Roel A Coutinho ◽  
Nicole HTM Dukers
Keyword(s):  
Viral Load ◽  
Sexual Risk ◽  
Risk Behaviour ◽  
Sexual Risk Behaviour ◽  
Homosexual Men ◽  
Hiv 1

Sexual risk behaviours and HIV-1 prevalence among urban men who have sex with men in Cape Town, South Africa

Sexual Health ◽  
2010 ◽  
Vol 7 (2) ◽  
pp. 149 ◽  
Author(s):  
Earl Burrell ◽  
Daniella Mark ◽  
Robert Grant ◽  
Robin Wood ◽  
Linda-Gail Bekker
Keyword(s):  
South Africa ◽  
Sexual Risk ◽  
Cape Town ◽  
Risk Behaviour ◽  
Hiv Prevalence ◽  
Sexual Risk Behaviour ◽  
Risk Behaviours ◽  
Cross Sectional ◽  
Sex With Men ◽  
Hiv 1

Background: Distinct homosexual and heterosexual HIV epidemics have previously been recognised in South Africa. However, linked HIV prevalence and self-reported sexual risk behaviour data have not been reported for men who have sex with men (MSM) in Cape Town since 1986. Methods: We conducted a cross-sectional, anonymous, venue-based HIV risk behaviour and prevalence study of 542 self-identified MSM in greater Cape Town using a self-administered risk questionnaire and the OraSure® testing device to asses HIV-1 prevalence. Results: This sample had an overall HIV prevalence of 10.4% (56/539). We found that self-identifying as gay, homosexual or queer (adjusted odds ratio (AOR) 4.5, 95% confidence interval (CI) 1.0–20.0) and reporting ever having had a sexually transmissible infection diagnosis (AOR 4.3, 95% CI: 2.3–8.3) were significantly predictive of testing HIV-1 positive, while reporting unprotected anal intercourse with a known HIV-negative partner (AOR 0.4, 95% CI: 0.2–0.9) was significantly protective. Conclusion: These data suggest a mature epidemic with consistent high-risk taking among MSM in Cape Town, and significant associations of select self-reported risk behaviours and HIV-1 serostatus. There is a need for continued and robust HIV surveillance along with detailed risk behaviour trends over time to inform the development of targeted risk-reduction interventions for this population.

Sexual risk behaviour relates to the virological and immunological improvements during highly active antiretroviral therapy in HIV-1 infection

AIDS ◽  
2001 ◽  
Vol 15 (3) ◽  
pp. 369-378 ◽  
Author(s):  
Nicole H. T. M. Dukers ◽  
Jaap Goudsmit ◽  
John B. F. de Wit ◽  
Maria Prins ◽  
Gerrit-Jan Weverling ◽  
...  
Keyword(s):  
Antiretroviral Therapy ◽  
Sexual Risk ◽  
Highly Active Antiretroviral Therapy ◽  
Risk Behaviour ◽  
Sexual Risk Behaviour ◽  
Highly Active ◽  
Hiv 1

scholarly journals Characterising HIV transmission risk among US patients with HIV in care: a cross-sectional study of sexual risk behaviour among individuals with viral load above 1500 copies/mL

2017 ◽  
Vol 94 (3) ◽  
pp. 206-211 ◽  
Author(s):  
Michael J Stirratt ◽  
Gary Marks ◽  
Christine O’Daniels ◽  
Edward R Cachay ◽  
Meg Sullivan ◽  
...  
Keyword(s):  
Viral Load ◽  
Sexual Risk ◽  
Hiv Transmission ◽  
Risk Behaviour ◽  
Cross Sectional Study ◽  
Transmission Risk ◽  
Sexual Risk Behaviour ◽  
Sexually Active ◽  
Cross Sectional ◽  
Viral Loads

ObjectivesViral load and sexual risk behaviour contribute to HIV transmission risk. High HIV viral loads present greater transmission risk than transient viral ‘blips’ above an undetectable level. This paper therefore characterises sexual risk behaviour among patients with HIV in care with viral loads>1500 copies/mL and associated demographic characteristics.MethodsThis cross-sectional study was conducted at six HIV outpatient clinics in USA. The study sample comprises 1315 patients with HIV with a recent viral load >1500 copies/mL. This study sample was drawn from a larger sample of individuals with a recent viral load >1000 copies/mL who completed a computer-assisted self-interview (CASI) regarding sexual risk practices in the last 2 months. The study sample was 32% heterosexual men, 38% men who have sex with men (MSM) and 30% women.ResultsNinety per cent of the sample had their viral load assay within 60 days of the CASI. Thirty-seven per cent reported being sexually active (vaginal or anal intercourse) in the last 2 months. Most of the sexually active participants reported always using condoms (56.9%) or limiting condomless sex to seroconcordant partners (serosorting; 29.2% overall and 42.9% among MSM). Among sexually active participants who reported condomless anal or vaginal sex with an at-risk partner (14%), most had viral loads>10 000 copies/mL (62%).ConclusionsA relatively small number of patients with HIV in care with viral loads above 1500 copies/mL reported concurrent sexual transmission risk behaviours. Most of the individuals in this small group had markedly elevated viral loads, increasing the probability of transmission. Directing interventions to patients in care with high viral loads and concurrent risk behaviour could strengthen HIV prevention and reduce HIV infections.Trial registration numberNCT02044484, completed.

scholarly journals Influence of sexual risk behaviour and STI co-infection dynamics on the evolution of HIV set point viral load in MSM

2019 ◽  
Author(s):  
Diana M Hendrickx ◽  
Wim Delva ◽  
Niel Hens
Keyword(s):  
Viral Load ◽  
Sexual Risk ◽  
Viral Evolution ◽  
Risk Behaviour ◽  
Sexual Risk Behaviour ◽  
Transmitted Infection ◽  
Set Point ◽  
Sexually Transmitted ◽  
Infection Dynamics ◽  
Before And After

AbstractHIV set-point viral load (SPVL) is an important predictor of HIV progression and transmission. Although it has been reported that anti-retroviral therapy (ART) reduces viral load (VL), increased SPVL levels have been observed in MSM in the decade following the introduction of ART in the Netherlands. Several studies have been devoted to explain these counter-intuitive trends in SPVL. However, to our knowledge, none of these studies has investigated an explanation in which it arises as the result of a sexually transmitted infection (STI) co-factor in detail.In this study, we adapted an event-based, individual-based model to investigate how STI co-infection and sexual risk behaviour affect the evolution of HIV SPVL in MSM before and after the introduction of ART.The results suggest that both STI co-factors and sexual risk behaviour have an effect on SPVL. However, the observed trends in SPVL cannot be explained by sexual risk behaviour and STI co-factors only.We recommend to develop mathematical models including also factors related to viral evolution as reported earlier in the literature. However, this requires more complex models, and the collection of more data for parameter estimation than what is currently available.

HAART, viral load and sexual risk behaviour

AIDS ◽  
2005 ◽  
Vol 19 (2) ◽  
pp. 205-207 ◽  
Author(s):  
Jonathan Elford ◽  
Graham Hart
Keyword(s):  
Viral Load ◽  
Sexual Risk ◽  
Risk Behaviour ◽  
Sexual Risk Behaviour

Randomised, controlled, community-level HIV-prevention intervention for sexual-risk behaviour among homosexual men in US cities

The Lancet ◽  
1997 ◽  
Vol 350 (9090) ◽  
pp. 1500-1505 ◽  
Author(s):  
Jeffrey A Kelly ◽  
Debra A Murphy ◽  
Kathleen J Sikkema ◽  
Timothy L McAuliffe ◽  
Roger A Roffman ◽  
...  
Keyword(s):  
Hiv Prevention ◽  
Sexual Risk ◽  
Risk Behaviour ◽  
Community Level ◽  
Sexual Risk Behaviour ◽  
Homosexual Men ◽  
Prevention Intervention ◽  
Hiv Prevention Intervention ◽  
Randomised Controlled ◽  
Us Cities
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