Regional pulmonary blood flow during partial liquid ventilation in normal and acute oleic acid-induced lung-injured piglets

1999 ◽  
Vol 27 (12) ◽  
pp. 2716-2723 ◽  
Author(s):  
Maria A. Enrione ◽  
Michele C. Papo ◽  
Corinne L. Leach ◽  
Bruce A. Holm ◽  
Lynn J. Hernan ◽  
...  
Keyword(s):  
Blood Flow ◽  
Oleic Acid ◽  
Pulmonary Blood Flow ◽  
Partial Liquid Ventilation ◽  
Liquid Ventilation

Distribution of pulmonary blood flow and total lung water during partial liquid ventilation in acute lung injury

Surgery ◽  
1997 ◽  
Vol 122 (2) ◽  
pp. 313-323 ◽  
Author(s):  
Paul G Gauger ◽  
Michael C Overbeck ◽  
Robert A Koeppe ◽  
Barry L Shulkin ◽  
Julia N Hrycko ◽  
...  
Keyword(s):  
Blood Flow ◽  
Acute Lung Injury ◽  
Lung Injury ◽  
Pulmonary Blood Flow ◽  
Partial Liquid Ventilation ◽  
Lung Water ◽  
Liquid Ventilation

scholarly journals Redistribution of Regional Pulmonary Blood Flow During Partial Liquid Ventilation. ▴ 261

1996 ◽  
Vol 39 ◽  
pp. 46-46 ◽  
Author(s):  
Allan Doctor ◽  
Juan Ibla ◽  
Barry Grenier ◽  
John Thompson ◽  
Craig Lillehei ◽  
...  
Keyword(s):  
Blood Flow ◽  
Pulmonary Blood Flow ◽  
Partial Liquid Ventilation ◽  
Liquid Ventilation

Changes in Pulmonary Blood Flow during Gaseous and Partial Liquid Ventilation in Experimental Acute Lung Injury

2000 ◽  
Vol 93 (6) ◽  
pp. 1437-1445 ◽  
Author(s):  
Martin Max ◽  
Bernd Nowak ◽  
Rolf Dembinski ◽  
Gernot Schulz ◽  
Ralf Kuhlen ◽  
...  
Keyword(s):  
Blood Flow ◽  
Acute Lung Injury ◽  
Lung Injury ◽  
Pulmonary Blood Flow ◽  
Arterial Oxygen ◽  
Pulmonary Vasculature ◽  
Emission Computed Tomography ◽  
Partial Liquid Ventilation ◽  
Arterial Oxygenation ◽  
Liquid Ventilation

Background It has been proposed that partial liquid ventilation (PLV) causes a compression of the pulmonary vasculature by the dense perfluorocarbons and a subsequent redistribution of pulmonary blood flow from dorsal to better-ventilated middle and ventral lung regions, thereby improving arterial oxygenation in situations of acute lung injury. Methods After induction of acute lung injury by repeated lung lavage with saline, 20 pigs were randomly assigned to partial liquid ventilation with two sequential doses of 15 ml/kg perfluorocarbon (PLV group, n = 10) or to continued gaseous ventilation (GV group, n = 10). Single-photon emission computed tomography was used to study regional pulmonary blood flow. Gas exchange, hemodynamics, and pulmonary blood flow were determined in both groups before and after the induction of acute lung injury and at corresponding time points 1 and 2 h after each instillation of perfluorocarbon in the PLV group. Results During partial liquid ventilation, there were no changes in pulmonary blood flow distribution when compared with values obtained after induction of acute lung injury in the PLV group or to the animals submitted to gaseous ventilation. Arterial oxygenation improved significantly in the PLV group after instillation of the second dose of perfluorocarbon. Conclusions In the surfactant washout animal model of acute lung injury, redistribution of pulmonary blood flow does not seem to be a major factor for the observed increase of arterial oxygen tension during partial liquid ventilation.

scholarly journals Pulmonary blood flow distribution during partial liquid ventilation

1998 ◽  
Vol 84 (5) ◽  
pp. 1540-1550 ◽  
Author(s):  
Allan Doctor ◽  
Juan C. Ibla ◽  
Barry M. Grenier ◽  
David Zurakowski ◽  
Michelle L. Ferretti ◽  
...  
Keyword(s):  
Blood Flow ◽  
Pulmonary Blood Flow ◽  
Scintillation Counter ◽  
Flow Distribution ◽  
Conventional Mechanical Ventilation ◽  
Partial Liquid Ventilation ◽  
Mean Flow ◽  
Liquid Ventilation ◽  
Regional Flow ◽  
Hilar Region

Regional pulmonary blood flow was investigated with radiolabeled microspheres in four supine lambs during the transition from conventional mechanical ventilation (CMV) to partial liquid ventilation (PLV) and with incremental dosing of perfluorocarbon liquid to a cumulative dose of 30 ml/kg. Four lambs supported with CMV served as controls. Formalin-fixed, air-dried lungs were sectioned according to a grid; activity was quantitated with a multichannel scintillation counter, corrected for weight, and normalized to mean flow. During CMV, flow in apical and hilar regions favored dependent lung ( P < 0.001), with no gradient across transverse planes from apex to diaphragm. During PLV the gradient within transverse planes found during CMV reversed, most notably in the hilar region, favoring nondependent lung ( P = 0.03). Also during PLV, flow was profoundly reduced near the diaphragm ( P < 0.001), and across transverse planes from apex to diaphragm a dose-augmented flow gradient developed favoring apical lung ( P < 0.01). We conclude that regional flow patterns during PLV partially reverse those noted during CMV and vary dramatically within the lung from apex to diaphragm.

Effects of Vaporized Perfluorocarbon on Pulmonary Blood Flow and Ventilation/Perfusion Distribution in a Model of Acute Respiratory Distress Syndrome

2001 ◽  
Vol 95 (6) ◽  
pp. 1414-1421 ◽  
Author(s):  
Matthias Hübler ◽  
Jennifer E. Souders ◽  
Erin D. Shade ◽  
Nayak L. Polissar ◽  
Carmel Schimmel ◽  
...  
Keyword(s):  
Blood Flow ◽  
Oleic Acid ◽  
Gas Exchange ◽  
Lung Injury ◽  
Repeated Measures ◽  
Pulmonary Blood Flow ◽  
Analysis Of Covariance ◽  
Inert Gas ◽  
Low Flow ◽  
Repeated Measures Analysis

Background Perfluorocarbon (PFC) liquids are known to improve gas exchange and pulmonary function in various models of acute respiratory failure. Vaporization has been recently reported as a new method of delivering PFC to the lung. Our aim was to study the effect of PFC vapor on the ventilation/perfusion (VA/Q) matching and relative pulmonary blood flow (Qrel) distribution. Methods In nine sheep, lung injury was induced using oleic acid. Four sheep were treated with vaporized perfluorohexane (PFX) for 30 min, whereas the remaining sheep served as control animals. Vaporization was achieved using a modified isoflurane vaporizer. The animals were studied for 90 min after vaporization. VA/Q distributions were estimated using the multiple inert gas elimination technique. Change in Qrel distribution was assessed using fluorescent-labeled microspheres. Results Treatment with PFX vapor improved oxygenation significantly and led to significantly lower shunt values (P &lt; 0.05, repeated-measures analysis of covariance). Analysis of the multiple inert gas elimination technique data showed that animals treated with PFX vapor demonstrated a higher VA/Q heterogeneity than the control animals (P &lt; 0.05, repeated-measures analysis of covariance). Microsphere data showed a redistribution of Qrel attributable to oleic acid injury. Qrel shifted from areas that were initially high-flow to areas that were initially low-flow, with no difference in redistribution between the groups. After established injury, Qrel was redistributed to the nondependent lung areas in control animals, whereas Qrel distribution did not change in treatment animals. Conclusion In oleic acid lung injury, treatment with PFX vapor improves gas exchange by increasing VA/Q heterogeneity in the whole lung without a significant change in gravitational gradient.

PEEP only partly restores disturbed distribution of regional pulmonary blood flow in lung injury

1998 ◽  
Vol 274 (1) ◽  
pp. H209-H216
Author(s):  
M. Kleen ◽  
B. Zwissler ◽  
K. Messmer
Keyword(s):  
Blood Flow ◽  
Fractal Dimension ◽  
Oleic Acid ◽  
Lung Injury ◽  
Pulmonary Blood Flow ◽  
Glass Bead ◽  
Relative Dispersion ◽  
Anesthetized Dogs ◽  
Peep Ventilation ◽  
Bead Injection

The effects of lung injury, positive end-expiratory pressure (PEEP), and norepinephrine on heterogeneity of regional pulmonary blood flow (rPBF, radioactive microspheres) were investigated. We hypothesized that lung injury increases heterogeneity of rPBF and that PEEP ventilation reduces these effects. Heterogeneity of rPBF is scale dependent and was therefore assessed in detail. Local correlation (ρ), relative dispersion (RD), fractal dimension (D), perfusion gradients, and histograms of rPBF each measures a different aspect of heterogeneity. In eight anesthetized dogs, lung injury was induced with oleic acid and glass bead injection. Afterward, PEEP of 10–20 cmH2O was instituted. Norepinephrine was infused at 20 cmH2O PEEP. Heterogeneity increased upon lung injury (ρ, 0.44 ± 0.09 vs. 0.24 ± 0.09; RD, 0.36 ± 0.06 vs. 0.64 ± 0.12; both P ≤ 0.05), but fractal dimension remained constant. PEEP did not change ρ, RD, or D. Perfusion gradients were reversed after lung injury (right, −27 ± 18 vs. 196 ± 115%; left, −24 ± 18 vs. 282 ± 184%; P ≤ 0.05). PEEP (10 cmH2O) reduced gradients (116 ± 73 and 143 ± 62%, respectively; P ≤ 0.05). Norepinephrine, in part, further reduced gradients (right, 50 ± 58%; P ≤ 0.05; left, 102 ± 94%; P = NS). We conclude that oleic acid- and glass bead-induced lung injury produces abnormal distribution of rPBF. Of these changes, application of PEEP only reverses perfusion gradients.

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