Detection of Tumors with 19F Magnetic Resonance Imaging

1988 ◽  
Vol 23 (5) ◽  
pp. 361-364 ◽  
Author(s):  
ADAM V. RATNER ◽  
HOLDE H. MULLER ◽  
BEVERLY BRADLEY-SIMPSON ◽  
DANNA E. JOHNSON ◽  
RALPH E. HURD ◽  
...  
1991 ◽  
Vol 9 (1) ◽  
pp. 101-106 ◽  
Author(s):  
Benzhi Gong ◽  
Michael Gill ◽  
David B. Washburn ◽  
W. Clark Davenport ◽  
Dorothy Adams ◽  
...  

PLoS ONE ◽  
2016 ◽  
Vol 11 (10) ◽  
pp. e0163704 ◽  
Author(s):  
Alexander J. Taylor ◽  
Josef Granwehr ◽  
Clémentine Lesbats ◽  
James L. Krupa ◽  
Joseph S. Six ◽  
...  

2018 ◽  
Vol 10 (30) ◽  
pp. 25056-25068 ◽  
Author(s):  
Christakis Constantinides ◽  
Pooja Basnett ◽  
Barbara Lukasiewicz ◽  
Ricardo Carnicer ◽  
Edyta Swider ◽  
...  

Nanomaterials ◽  
2019 ◽  
Vol 9 (6) ◽  
pp. 879 ◽  
Author(s):  
Maria Şologan ◽  
Francesco Padelli ◽  
Isabella Giachetti ◽  
Domenico Aquino ◽  
Mariangela Boccalon ◽  
...  

Gold nanoparticles carrying fluorinated ligands in their monolayer are, by themselves, contrast agents for 19F magnetic resonance imaging displaying high sensitivity because of the high density of fluorine nuclei achievable by grafting suitable ligands on the gold core surface. Functionalization of these nanoparticles with Gd(III) chelates allows adding a further functional activity to these systems, developing materials also acting as contrast agents for proton magnetic resonance imaging. These dual mode contrast agents may allow capitalizing on the benefits of 1H and 19F magnetic resonance imaging in a single diagnostic session. In this work, we describe a proof of principle of this approach by studying these nanoparticles in a high field preclinical scanner. The Gd(III) centers within the nanoparticles monolayer shorten considerably the 19F T1 of the ligands but, nevertheless, these systems display strong and sharp NMR signals which allow recording good quality 19F MRI phantom images at nanoparticle concentration of 20 mg/mL after proper adjustment of the imaging sequence. The Gd(III) centers also influence the T1 relaxation time of the water protons and high quality 1H MRI images could be obtained. Gold nanoparticles protected by hydrogenated ligands and decorated with Gd(III) chelates are reported for comparison as 1H MRI contrast agents.


Langmuir ◽  
2017 ◽  
Vol 33 (40) ◽  
pp. 10531-10542 ◽  
Author(s):  
Meryem Bouchoucha ◽  
Ruud B. van Heeswijk ◽  
Yves Gossuin ◽  
Freddy Kleitz ◽  
Marc-André Fortin

2014 ◽  
Vol 110 ◽  
pp. 95-99 ◽  
Author(s):  
Xia Yang ◽  
Yi Sun ◽  
Sujit Kootala ◽  
Jöns Hilborn ◽  
Arend Heerschap ◽  
...  

2018 ◽  
Vol 54 (70) ◽  
pp. 9853-9856 ◽  
Author(s):  
Chang Guo ◽  
Suying Xu ◽  
Anila Arshad ◽  
Leyu Wang

A pH-responsive MRI nanoprobe was developed by partially replacing organic linkers in ZIF-8, which displays pH-responsive in vivo19F MRI ability.


2019 ◽  
Vol 25 (18) ◽  
pp. 4782-4792 ◽  
Author(s):  
Rosa Pujales‐Paradela ◽  
Tanja Savić ◽  
David Esteban‐Gómez ◽  
Goran Angelovski ◽  
Fabio Carniato ◽  
...  

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