Selective serotonin reuptake inhibitors in the treatment of paediatric anxiety disorders: a review

2000 ◽  
Vol 15 ◽  
pp. S47-S63 ◽  
Author(s):  
Tanya K Murphy ◽  
Michael A Bengtson ◽  
Jennifer Y Tan ◽  
Eric Carbonell ◽  
Gary M Levin
Keyword(s):  
Anxiety Disorders ◽  
Serotonin Reuptake ◽  
Selective Serotonin Reuptake Inhibitors ◽  
Serotonin Reuptake Inhibitors ◽  
Selective Serotonin

Understanding the Neurobiology of Comorbidity in Anxiety Disorders

CNS Spectrums ◽  
2006 ◽  
Vol 11 (S12) ◽  
pp. 13-20 ◽  
Author(s):  
David J. Nutt ◽  
Dan J. Stein
Keyword(s):  
Anxiety Disorders ◽  
Serotonin Reuptake ◽  
Selective Serotonin Reuptake Inhibitors ◽  
Serotonin Reuptake Inhibitors ◽  
Response To Treatment ◽  
Selective Serotonin ◽  
Anxiety And Depression ◽  
Brain Pathology ◽  
Receptor Function ◽  
Similarities And Differences

AbstractAnxiety and depression are common disorders that frequently co-exist. Both disorders show good response to antidepressants, especially the selective serotonin reuptake inhibitors. Some suggest that these disorders are variants of the same underlying brain pathology. This review examines the similarities and differences between anxiety and depression in terms of the known neurobiological etiologic mechanisms as well as their biological underpinnings and response to treatment. Sufficient and significant differences between these disorders support the view that they are independent entities. Shared abnormalities in the 5HT1A receptor function, for example, may help explain some of the comorbidity.

Overview of Diagnosis and Drug Treatments of Anxiety Disorders

CNS Spectrums ◽  
2005 ◽  
Vol 10 (1) ◽  
pp. 49-56 ◽  
Author(s):  
David J. Nutt
Keyword(s):  
Anxiety Disorder ◽  
Anxiety Disorders ◽  
Serotonin Reuptake ◽  
Selective Serotonin Reuptake Inhibitors ◽  
Serotonin Reuptake Inhibitors ◽  
Selective Serotonin ◽  
Obsessive Compulsive ◽  
Compulsive Disorder ◽  
Drug Treatments ◽  
The Common

AbstractAnxiety disorders are common and often disabling. They fall into five main categories: panic disorder, social anxiety disorder, generalized anxiety disorder, obsessive-compulsive disorder and posttraumatic stress disorder, each of which have characteristic symptoms and cognitions. All anxiety disorders respond to drugs and psychological treatments. This review will focus on drug treatments. Recent research has emphasized the value of antidepressants especially the selective serotonin reuptake inhibitors, benzodiazepines, and related sedative-like compounds. The common co-existence of depression with all of the anxiety disorders means that the selective serotonin reuptake inhibitors are now generally considered to be the first-line treatments but the benzodiazepines have some utility especiaRy in promoting sleep and working acutely to reduce extreme distress.

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