Bone Mineral Density of the Lumbar Spine in Children and Adolescents With Celiac Disease on a Gluten-Free Diet in São Paulo, Brazil

2003 ◽  
Vol 37 (5) ◽  
pp. 571-576 ◽  
Author(s):  
Vera Lucia Sdepanian ◽  
Cecília Noronha de Miranda Carvalho ◽  
Mauro Batista de Morais ◽  
Fernando Antonio Basile Colugnati ◽  
Ulysses Fagundes-Neto
2009 ◽  
Vol 127 (5) ◽  
pp. 278-282 ◽  
Author(s):  
Maria Eugênia Farias Almeida Motta ◽  
Maria Eduarda Nóbrega de Faria ◽  
Gisélia Alves Pontes da Silva

CONTEXT AND OBJECTIVE: Low bone mineral density may be a finding among children and adolescents with celiac disease, including those undergoing treatment with a gluten-free diet, but the data are contradictory. The aim of this study was to determine the frequency of bone mineral density abnormalities in patients on a gluten-free diet, considering age at diagnosis and duration of dietary treatment. DESIGN AND SETTING: Cross-sectional prevalence study at the Pediatric Gastroenterology Outpatient Clinic of Instituto Materno Infantil Professor Fernando Figueira. METHODS: Thirty-one patients over five years of age with celiac disease and on a gluten-free diet were enrolled. Bone mineral density (in g/cm²) was measured in the lumbar spine and whole body using bone densitometry and categorized using the criteria of the International Society for Clinical Densitometry, i.e. low bone mineral density for chronological age < -2.0 Z-scores. Age at diagnosis and duration of dietary treatment were confirmed according to the date of starting the gluten-free diet. RESULTS: Low bone density for chronological age was present in 3/31 patients in the lumbar spine and 1/31 in the whole body (also with lumbar spine abnormality). At diagnosis, three patients with low bone mineral density for the chronological age were more than 7.6 years old. These patients had been on a gluten-free diet for six and seven months and 3.4 years. CONCLUSION: Pediatric patients with celiac disease on long-term treatment are at risk of low bone mineral density. Early diagnosis and long periods of gluten-free diet are directly implicated in bone density normalization.


Bone ◽  
2010 ◽  
Vol 47 (3) ◽  
pp. 598-603 ◽  
Author(s):  
Štefan Blazina ◽  
Nevenka Bratanič ◽  
Andreja Širca Čampa ◽  
Rok Blagus ◽  
Rok Orel

2014 ◽  
Vol 47 (9) ◽  
pp. 775
Author(s):  
L.M. Lasta ◽  
M.E. ◽  
M.P. Gentili ◽  
C. Capiel ◽  
C. Spomer ◽  
...  

2005 ◽  
Vol 60 (3) ◽  
pp. 358-363 ◽  
Author(s):  
C Tau ◽  
C Mautalen ◽  
S De Rosa ◽  
A Roca ◽  
X Valenzuela

2010 ◽  
Vol 138 (5) ◽  
pp. S-308 ◽  
Author(s):  
Konstantinos Papamichael ◽  
Evangelos Kokkinakis ◽  
Emmanuel J. Archavlis ◽  
Ioannis Theodoropoulos ◽  
Dimitrios Tzivras ◽  
...  

2009 ◽  
Vol 33 (2) ◽  
pp. 109-114 ◽  
Author(s):  
R. Heyman ◽  
P. Guggenbuhl ◽  
A. Corbel ◽  
L. Bridoux-Henno ◽  
Y. Tourtelier ◽  
...  

2018 ◽  
Vol 21 (02) ◽  
pp. 275-279
Author(s):  
Sikandar Ali Bhand ◽  
Farzana Shaikh ◽  
Hussain Bux Korejo ◽  
Syed Jamal Raza

Objective: To evaluate effectiveness of treating previously untreated patients withceliac disease with both a gluten free diet and bisphosphonate in order to significantly increasetheir BMD’s to a greater extent than a gluten free diet alone. Patients and methods: The studywas conducted in National Institute of Child Health (NICH) Karachi to evaluate the effectiveness oftreating previously untreated patients with celiac disease with a gluten free diet andbisphosphonate in terms of increase in bone mineral density in comparison to a gluten free dietalone over a period of three months (January 2013 – March 2013). The study includes 30 childrenpatients below fifteen years of age either sex. All study subjects were untreated celiac patientsdiagnosed by clinical presentation, small bowel histology and serologic testing. On day dexascan was done. Fifteen patients kept on Gluten Free Diet (GFD) and remaining 15 patients keptGFD plus tablet of bisphosphonate. After three months dexa scan was repeated. The patientswith other disease of bone or mineral metabolism, as well as subjects taking systemicglucocorticoids or high doses of thyroid hormones, were excluded. Results: A total of 30 patientswith celiac disease were included in this study. Out of 30 patients 18 (60%) were female and 12(40%) male (M: F = 1:1.5). Thirty patients were divided in two equal groups (15 patients in eachgroup). In group-I we gave gluten free diet and in group-II we gave gluten free diet and one tabletof bisphosphonate. Mean± SD of Bone Mineral Density (BMD) in group-I was 0.402± 0.081gm/cm2 (range=0.234 – 0.503 gm/cm2), and in group-II was 0.543± 0.098 gm/cm2 (range=0.402 – 0.743 gm/cm2), mean difference of bone mineral density was significant between twogroups (P-value=0.0002). Conclusions: At three months DEXA scan showed a significant rise inBMD in group-II as compared to group-I


PEDIATRICS ◽  
2001 ◽  
Vol 108 (5) ◽  
pp. e89-e89 ◽  
Author(s):  
A. G. Kalayci ◽  
A. Kansu ◽  
N. Girgin ◽  
O. Kucuk ◽  
G. Aras

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