Effects of Pinacidil on Myocardial Blood Flow and Infarct Size After Acute Left Anterior Descending Coronary Artery Occlusion and Reperfusion in Awake Dogs With and Without a Coexisting Left Circumflex Coronary Artery Stenosis

1989 ◽  
Vol 14 (5) ◽  
pp. 747-755 ◽  
Author(s):  
Susumu Sakamoto ◽  
Chang-seng Liang ◽  
Charles K. Stone ◽  
William B. Hood
Keyword(s):  
Blood Flow ◽  
Coronary Artery ◽  
Myocardial Blood Flow ◽  
Infarct Size ◽  
Coronary Artery Stenosis ◽  
Coronary Artery Occlusion ◽  
Artery Occlusion ◽  
Artery Stenosis ◽  
Circumflex Coronary Artery ◽  
Left Circumflex Coronary Artery

Effect of hyperoxia on regional blood flow after coronary occlusion in awake dogs

1980 ◽  
Vol 238 (2) ◽  
pp. H244-H248 ◽  
Author(s):  
F. Rivas ◽  
J. C. Rembert ◽  
R. J. Bache ◽  
F. R. Cobb ◽  
J. C. Greenfield
Keyword(s):  
Blood Flow ◽  
Coronary Artery ◽  
Myocardial Blood Flow ◽  
Regional Blood Flow ◽  
Coronary Artery Occlusion ◽  
Artery Occlusion ◽  
Regional Myocardial Blood Flow ◽  
Circumflex Coronary Artery ◽  
Left Circumflex Coronary Artery ◽  
Oxygen Inhalation

The effect of 100% oxygen inhalation on regional transmural myocardial blood flow following 45 s of actue total left circumflex coronary artery occlusion was studied in six awake dogs chronically instrumented with a coronary occluder and catheters in the aorta and left atrium. After inhalation of either room air or 100% oxygen for at least 30 min and following the 45-s occlusion, transmural myocardial blood flow was determined with radioactive microspheres (7--10 micrometers). Each dog underwent two occlusions of the left circumflex coronary artery; one during inhalation of rrom air and the other during 100% oxygen. During room air inhalation, mean regional myocardial blood flow to nonischemic, intermediate, and ischemic regions was 0.92 +/- 0.05, 0.51 +/- 0.08, and 0.10 +/- 0.02 ml . min-1 . g-1, respectively. During 100% oxygen administration, flow was significantly diminished in each region to 0.75 +/- 0.04, 0.41 +/- 0.07, and 0.06 +/- 0.01 ml . min-1 . g-1, respectively. Transmural blood flow to each layer was uniformly reduced in all regions. These data indicate that 100% oxygen further reduces myocardial blood flow to ischemic regions.

Increased myocardial infarct size because of reduced coronary collateral blood flow in beagles

1989 ◽  
Vol 257 (6) ◽  
pp. H1798-H1803 ◽  
Author(s):  
N. Uemura ◽  
D. R. Knight ◽  
Y. T. Shen ◽  
J. Nejima ◽  
M. V. Cohen ◽  
...  
Keyword(s):  
Blood Flow ◽  
Coronary Artery ◽  
Myocardial Blood Flow ◽  
Infarct Size ◽  
Myocardial Infarct ◽  
Left Ventricular ◽  
Myocardial Infarct Size ◽  
Circumflex Coronary Artery ◽  
Area At Risk ◽  
Left Circumflex Coronary Artery

Effects of permanent left circumflex coronary artery occlusion (CAO) were examined in conscious purebred beagles and mongrel dogs, instrumented with miniature left ventricular (LV) pressure gauges, wall thickness gauges in the ischemic zone, catheters in left atrium and aorta, and snares around the left circumflex coronary artery. Blood flow was measured using the radioactive microsphere technique before CAO and at 5 min, 1, 3, and 24 h after CAO. Although CAO reduced myocardial blood flow similarly in beagles and mongrels, significantly less (P less than 0.05) recovery of myocardial blood flow was observed over the following 24-h period in beagles. Infarct size, as determined by triphenyltetrazolium chloride and expressed as percentage of area at risk, was larger (P less than 0.05) in beagles (62.0 +/- 5.1%) than mongrels (42.5 +/- 4.2%). Thus beagles do not tolerate ischemia as well as mongrel dogs and possess fewer functional coronary collaterals resulting in larger infarcts after CAO.

scholarly journals Left circumflex coronary artery occlusion due to a left atrial appendage closure device

2015 ◽  
Vol 1 ◽  
pp. 69-70
Author(s):  
András Katona ◽  
András Temesvári ◽  
András Szatmári ◽  
Attila Nemes ◽  
Tamás Forster ◽  
...  
Keyword(s):  
Coronary Artery ◽  
Left Atrial ◽  
Left Atrial Appendage ◽  
Coronary Artery Occlusion ◽  
Artery Occlusion ◽  
Atrial Appendage ◽  
Closure Device ◽  
Circumflex Coronary Artery ◽  
Left Atrial Appendage Closure ◽  
Left Circumflex Coronary Artery

Responses to coronary artery occlusion in conscious dogs with selective cardiac denervation

1988 ◽  
Vol 255 (3) ◽  
pp. H525-H533 ◽  
Author(s):  
Y. T. Shen ◽  
D. R. Knight ◽  
S. F. Vatner ◽  
W. C. Randall ◽  
J. X. Thomas
Keyword(s):  
At Risk ◽  
Blood Flow ◽  
Coronary Artery ◽  
Infarct Size ◽  
Coronary Artery Occlusion ◽  
Artery Occlusion ◽  
Conscious Dogs ◽  
Wall Thickening ◽  
Area At Risk ◽  
Cardiac Denervation

The extent to which cardiac denervation alters responses to myocardial ischemia remains controversial. This study compared responses to 24-h coronary artery occlusion (CAO) on measurements of wall thickness (ultrasonic crystals), regional myocardial blood flow (microspheres), and infarct size (triphenyltetrazolium chloride technique) in three groups of conscious dogs with 1) selective posterior left ventricular (LV) wall denervation, 2) selective ventricular denervation, or in 3) intact dogs. After CAO, hemodynamic changes were not different among the three groups. Wall thickening in the ischemic zone became akinetic or paradoxical early after CAO and did not recover in any group over the 24-h monitoring period. Blood flow in the area at risk fell similarly in all groups. Infarct size, as a percentage of the area at risk, was 45 +/- 7% in intact, 48 +/- 6% in posterior LV wall-denervated, and 48 +/- 8% in ventricular-denervated group. There was, however, a lower (P less than 0.05) frequency of arrhythmic beats per minute after 3 h of CAO in the ventricular-denervated group (3.2 +/- 1.4) compared with the intact (11.3 +/- 4.1) or posterior wall-denervated (12.6 +/- 3.2) group. An additional group of ventricular-denervated dogs was studied to determine the effects of sequential, brief 2-min CAO at 2, 4, and 8 wk after denervation. Responses of regional wall thickening to CAO were not affected significantly even after 8 wk following ventricular denervation. Thus, in conscious dogs, neither selective ventricular denervation nor selective denervation of the posterior LV wall improved collateral blood flow, affected regional function favorably, or reduced infarct size after CAO.

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