Radiolabelled white blood cells and inflammatory bowel disease

2003 ◽  
Vol 24 (4) ◽  
pp. 441
Author(s):  
H. W. GRAY
Keyword(s):  
Inflammatory Bowel Disease ◽  
Bowel Disease ◽  
Blood Cells ◽  
White Blood Cells ◽  
Inflammatory Bowel

scholarly journals The Subpopulations of Circulating White Blood Cells in Inflammatory Bowel Disease

1976 ◽  
Vol 71 (3) ◽  
pp. 379-384 ◽  
Author(s):  
Walter R. Thayer ◽  
Colette Charland ◽  
Cynthia E. Field
Keyword(s):  
Inflammatory Bowel Disease ◽  
Bowel Disease ◽  
Blood Cells ◽  
White Blood Cells ◽  
Inflammatory Bowel

Azathioprine in the therapy of paediatric inflammatory bowel disease – part II: pharmacodynamics, pharmacokinetics, and the possibilities of measuring its metabolites in clinical practice

2021 ◽  
Vol 75 (6) ◽  
pp. 508-514
Author(s):  
Kristýna Pospíšilová ◽  
Jiří Bronský
Keyword(s):  
Ulcerative Colitis ◽  
Inflammatory Bowel Disease ◽  
Bowel Disease ◽  
Blood Cells ◽  
Thiopurine Methyltransferase ◽  
Active Metabolites ◽  
Thioguanine Nucleotide ◽  
Inflammatory Bowel ◽  
Keywords Crohn's Disease ◽  
Hypoxanthine Guanine Phosphoribosyl Transferase

Summary Background: Thiopurines (predominantly azathioprine and mercaptopurine) are widely used in paediatrics to maintain remission in the treatment of inflammatory bowel disease. After its absorption from the gastrointestinal tract, azathioprine is converted into 6 mercaptopurine in approximately 90%. Several enzymes (such as thiopurine methyltransferase, xanthine oxidase and hypoxanthine-guanine phosphoribosyl transferase) participate in its further metabolism, producing non-active methylated metabolites (6 methylmercaptopurine) and thiouric acid and active 6-thioguanine nucleotide. The concentration of these metabolites can be measured in red blood cells. Aim: To map the benefits and possibilities of thiopurine metabolites measurements in patients suffering from inflammatory bowel disease. Conclusion: The measurement of active and non-active metabolites can help evaluate the bioavailability of those drugs, identify some causes of adverse effects and reveal non-adherence. Keywords Crohn’s disease, merkaptopurin, pediatrie, thiopuriny, ulcerative colitis

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