Critical Role of Phosphagens in the Energy Cascade of Cutaneous Ischemia and Protective Action of Phosphocreatine Analogues in Skin Flap Survival

1998 ◽  
Vol 101 (6) ◽  
pp. 1597-1603 ◽  
Author(s):  
Charles B. Cuono ◽  
Ralph Marquetand ◽  
Matthew B. Klein ◽  
Ian Armitage
Keyword(s):  
Protective Action ◽  
Skin Flap ◽  
Critical Role ◽  
Energy Cascade ◽  
Flap Survival ◽  
Skin Flap Survival

Ivermectin Increases Random-Pattern Skin Flap Survival in Rats: The Novel Role of GABAergic System

2020 ◽  
Author(s):  
Mohammadreza Tabary ◽  
Armin Aryannejad ◽  
Nafise Noroozi ◽  
Seyed Mohammad Tavangar ◽  
Razieh Mohammad Jafari ◽  
...  
Keyword(s):  
Skin Flap ◽  
Gabaergic System ◽  
Random Pattern ◽  
The Novel ◽  
Flap Survival ◽  
Skin Flap Survival

The Role of Endogenous Bacterial Flora in Skin Flap Survival

1980 ◽  
Vol 65 (1) ◽  
pp. 50-55 ◽  
Author(s):  
Steven D. Macht ◽  
William H. Frazier
Keyword(s):  
Skin Flap ◽  
Bacterial Flora ◽  
Flap Survival ◽  
Skin Flap Survival

scholarly journals Role of adipose-derived stromal cells in pedicle skin flap survival in experimental animal models

2016 ◽  
Vol 8 (3) ◽  
pp. 101 ◽  
Author(s):  
Pericles Foroglou ◽  
Vasileios Karathanasis ◽  
Efterpi Demiri ◽  
George Koliakos ◽  
Marios Papadakis
Keyword(s):  
Animal Models ◽  
Experimental Animal ◽  
Stromal Cells ◽  
Skin Flap ◽  
Experimental Animal Models ◽  
Flap Survival ◽  
Adipose Derived Stromal Cells ◽  
Skin Flap Survival

Involvement of cannabinoid type 2 (CB2) receptors in the favorable effects of sumatriptan on the random-pattern skin flap survival in rats: a novel potential target

2021 ◽  
Author(s):  
Armin Aryannejad ◽  
Nafise Noroozi ◽  
Seyed Mohammad Tavangar ◽  
Samira Ramezani ◽  
Amir Rashidian ◽  
...  
Keyword(s):  
Skin Flap ◽  
Control Group ◽  
Random Pattern ◽  
Protective Effects ◽  
Flap Survival ◽  
Tnf Α ◽  
Skin Flap Survival ◽  
Cb2 Receptors

Introduction: Recent investigations have indicated the potential therapeutic role of cannabinoid type 2 (CB2) receptors in various inflammatory-related disorders. However, the role of these receptors has not been studied in skin flap models previously. In this study, we aimed to evaluate the possible involvement of CB2 receptors in the anti-inflammatory effects of sumatriptan and improvement of the random-pattern skin flap survival in rats. Methods: In a controlled experimental study, 36 male Wistar rats were randomly divided into six study groups (n = 6 per group). Two doses of sumatriptan (0.1 and 0.3 mg/kg) were administered intraperitoneally (i.p) 30 minutes before harvesting the flap tissue. In a separate group, SR144528 (a selective CB2 receptor inverse agonist) was injected before the most effective dose of sumatriptan to determine the possible involvement of CB2 receptors in its action. Histopathological examinations, the expression level of CB2 receptors (by western blot analysis), and IL-1 and TNF-α concentrations (ELISA) were explored in the skin flap samples. Results: Sumatriptan 0.3 mg/kg remarkably enhanced the skin flap survival in all macroscopic and microscopic investigations compared to the control group (P <0.001). IL-1 and TNF-α levels were significantly attenuated (P <0.001), and the expression of CB2 receptors in skin cells was amplified in rats treated with sumatriptan 0.3 mg/kg (p <0.05) compared to the control group. However, the administration of SR144528 (2 mg/kg) nullified all the protective effects of sumatriptan (0.3 mg/kg). Conclusion: We discovered that CB2 receptors play a crucial role in the favorable effects of sumatriptan on skin flap survival as a novel mechanism of action. So, targeting these receptors seems to be a dependable method in skin flap surgeries to ensure its survival and prevent tissue necrosis. Further experimental and clinical investigations are needed to ensure the safe clinical application of this method.

The Effects of Vasonatrin Peptide on Random Pattern Skin Flap Survival

2014 ◽  
Vol 72 (1) ◽  
pp. 94-99 ◽  
Author(s):  
Shi-Ping Wang ◽  
Zhi-Yong Lan ◽  
Wei Xia ◽  
Xi Zhao ◽  
Ge-Jia Ma ◽  
...  
Keyword(s):  
Skin Flap ◽  
Random Pattern ◽  
Flap Survival ◽  
Skin Flap Survival
Sign in / Sign up

Export Citation Format

Share Document