Mechanisms of Stimulatory Effect of Neuromedin C on Pancreatic Exocrine Secretion in Conscious Rats

Pancreas ◽  
1994 ◽  
Vol 9 (5) ◽  
pp. 585-590 ◽  
Author(s):  
Kenji Okubo ◽  
Kyoko Miyasaka ◽  
Masahiro Matsumoto ◽  
Akihiro Funakoshi
Keyword(s):  
Exocrine Secretion ◽  
Pancreatic Exocrine Secretion ◽  
Conscious Rats ◽  
Pancreatic Exocrine

Effect of Cholecystokinin1 Receptor Antagonist Loxiglumide (CR1505) on Basal Pancreatic Exocrine Secretion in Conscious Rats

Pancreas ◽  
2003 ◽  
Vol 26 (1) ◽  
pp. 87-91 ◽  
Author(s):  
Kaoru Ishizaki ◽  
Shigemasa Kinbara ◽  
Makoto Kawamura ◽  
Kunio Kimura ◽  
Keiko Shiratori ◽  
...  
Keyword(s):  
Receptor Antagonist ◽  
Exocrine Secretion ◽  
Pancreatic Exocrine Secretion ◽  
Conscious Rats ◽  
Pancreatic Exocrine

Inhibitory effect of central dopamine on basal pancreatic secretion in conscious rats

1998 ◽  
Vol 274 (1) ◽  
pp. G29-G34 ◽  
Author(s):  
Masao Masuda ◽  
Setsuko Kanai ◽  
Kyoko Miyasaka
Keyword(s):  
Pancreatic Secretion ◽  
Sch 23390 ◽  
Sympathetic Nerves ◽  
Inhibitory Effect ◽  
Exocrine Secretion ◽  
External Jugular Vein ◽  
Pancreatic Exocrine Secretion ◽  
Conscious Rats ◽  
Brain Ventricle ◽  
Pancreatic Exocrine

We examined the role and the peripheral mechanism of action of central dopamine on basal pancreatic exocrine secretion in conscious rats. Rats were fitted with bile and pancreatic catheters to collect bile and pancreatic juice separately and also with a left lateral brain ventricle and external jugular vein catheters. After 90-min basal collection, the D1- and D2-receptor antagonists (Sch-23390 and eticlopride, respectively) and dopamine were administered into the lateral brain ventricle. Sch-23390 (30, 100, and 300 nmol/rat), but not eticlopride (300 nmol/rat), stimulated pancreatic fluid and protein secretion. Dopamine (30, 100, and 300 nmol/rat) inhibited pancreatic secretion dose dependently. Pretreatment with Sch-23390 prevented the inhibitory effect of dopamine. Intravenously injected Sch-23390 or dopamine had no effect on pancreatic secretion. The inhibitory effect of dopamine was blocked by bretylium, an inhibitor of norepinephrine release, and phentolamine, an α-blocker, but not by vagotomy. The β-antagonist propranolol alone significantly inhibited basal pancreatic secretion, and dopamine did not modify the inhibitory effect of propranolol. The proton pump inhibitor omeprazole partially but not completely reduced the inhibition by dopamine. These results suggest that central dopamine inhibits pancreatic exocrine secretion via D1-like receptors and that the inhibitory effect is mediated via sympathetic nerves, especially α-adrenoceptors.

Stimulative Effects of Saponin from Kikyo-to, a Japanese Herbal Medicine, on Pancreatic Exocrine Secretion of Conscious Rats

Planta Medica ◽  
1997 ◽  
Vol 63 (05) ◽  
pp. 419-424 ◽  
Author(s):  
Ichiro Arai ◽  
Yasuhiro Komatsu ◽  
Yasuaki Hirai ◽  
Kazushi Shingu ◽  
Yoshiteru Ida ◽  
...  
Keyword(s):  
Herbal Medicine ◽  
Exocrine Secretion ◽  
Pancreatic Exocrine Secretion ◽  
Conscious Rats ◽  
Japanese Herbal Medicine ◽  
Pancreatic Exocrine

scholarly journals Central Administration of Ghrelin Stimulates Pancreatic Exocrine Secretion via the Vagus in Conscious Rats

2003 ◽  
Vol 53 (6) ◽  
pp. 443-449 ◽  
Author(s):  
Norikazu Sato ◽  
Setsuko Kanai ◽  
Saeko Takano ◽  
Mieko Kurosawa ◽  
Akihiro Funakoshi ◽  
...  
Keyword(s):  
Exocrine Secretion ◽  
Central Administration ◽  
Pancreatic Exocrine Secretion ◽  
Conscious Rats ◽  
Pancreatic Exocrine
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