BACTERIAL ENDOTOXIN - A TRIGGER FACTOR FOR ALCOHOLIC PANCREATITIS (AP)? EVIDENCE FROM A NOVEL, PHYSIOLOGICALLY RELEVANT ANIMAL MODEL

Pancreas ◽  
2006 ◽  
Vol 33 (4) ◽  
pp. 506-507 ◽  
Author(s):  
A. Vonlaufen ◽  
Z. Xu ◽  
B. Daniel ◽  
S. Joshi ◽  
R. K. Kumar ◽  
...  
Keyword(s):  
Animal Model ◽  
Trigger Factor ◽  
Bacterial Endotoxin ◽  
Alcoholic Pancreatitis ◽  
Relevant Animal Model

Bacterial Endotoxin: A Trigger Factor for Alcoholic Pancreatitis? Evidence From a Novel, Physiologically Relevant Animal Model

2007 ◽  
Vol 133 (4) ◽  
pp. 1293-1303 ◽  
Author(s):  
Alain Vonlaufen ◽  
Zhihong Xu ◽  
Balu Daniel ◽  
Rakesh K. Kumar ◽  
Romano Pirola ◽  
...  
Keyword(s):  
Animal Model ◽  
Trigger Factor ◽  
Bacterial Endotoxin ◽  
Alcoholic Pancreatitis ◽  
Relevant Animal Model

Abstract 1249: Animal model in the prevention of alcoholic pancreatitis

2018 ◽  
Author(s):  
Supriya Srinivasan ◽  
Tulasigeri Totiger ◽  
Michael VanSaun ◽  
Fanuel Messaggio ◽  
Chanjuan Shi ◽  
...  
Keyword(s):  
Animal Model ◽  
Alcoholic Pancreatitis

Animal Model of Alcoholic Pancreatitis: Role of Viral Infections

Pancreas ◽  
2003 ◽  
Vol 27 (4) ◽  
pp. 301-304 ◽  
Author(s):  
Thomas R. Jerrells ◽  
Nora Chapman ◽  
Dahn L. Clemens
Keyword(s):  
Animal Model ◽  
Viral Infections ◽  
Alcoholic Pancreatitis

scholarly journals Characterization of the Kynurenine Pathway and Quinolinic Acid Production in Macaque Macrophages

2013 ◽  
Vol 6 ◽  
pp. IJTR.S11789 ◽  
Author(s):  
Chai K. Lim ◽  
Margaret M.C. Yap ◽  
Stephen J. Kent ◽  
Gabriel Gras ◽  
Boubekeur Samah ◽  
...  
Keyword(s):  
Animal Model ◽  
Inflammatory Cytokines ◽  
Quinolinic Acid ◽  
Kynurenine Pathway ◽  
Brain Diseases ◽  
Relevant Model ◽  
End Products ◽  
Relevant Animal Model ◽  
Genetic Makeup

The kynurenine pathway (KP) and one of its end-products, the excitotoxin quinolinic acid (QUIN), are involved in the pathogenesis of several major neuroinflammatory brain diseases. A relevant animal model to study KP metabolism is now needed to assess whether intervention in this pathway may improve the outcome of such diseases. Humans and macaques share a very similar genetic makeup. In this study, we characterized the KP metabolism in macaque primary macrophages of three different species in comparison to human cells. We found that the KP profiles in simian macrophages were very similar to those in humans when challenged with inflammatory cytokines. Further, we found that macaque macrophages are capable of producing a pathophysiological concentration of QUIN. Our data validate the simian model as a relevant model to study the human cellular KP metabolism in the context of inflammation.

Multiple System Organ Response Induced by Hyperoxia in a Clinically Relevant Animal Model of Sepsis

Shock ◽  
2014 ◽  
Vol 42 (2) ◽  
pp. 148-153 ◽  
Author(s):  
Raquel Rodríguez-González ◽  
José Luis Martín-Barrasa ◽  
Ángela Ramos-Nuez ◽  
Ana María Cañas-Pedrosa ◽  
María Teresa Martínez-Saavedra ◽  
...  
Keyword(s):  
Animal Model ◽  
Relevant Animal Model ◽  
Organ Response ◽  
Multiple System Organ ◽  
System Organ

scholarly journals Do we now have a relevant animal model for breast cancer?

10.1186/bcr2 ◽  
1999 ◽  
Vol 1 (1) ◽  
Author(s):  
Barry Gusterson ◽  
Beatrice Howard ◽  
Tim Crook ◽  
Barbara Tennent
Keyword(s):  
Breast Cancer ◽  
Animal Model ◽  
Relevant Animal Model

scholarly journals Complete Unique Genome Sequence, Expression Profile, and Salivary Gland Tissue Tropism of the Herpesvirus 7 Homolog in Pigtailed Macaques

2016 ◽  
Vol 90 (15) ◽  
pp. 6657-6674 ◽  
Author(s):  
Jeannette P. Staheli ◽  
Michael R. Dyen ◽  
Gail H. Deutsch ◽  
Ryan S. Basom ◽  
Matthew P. Fitzgibbon ◽  
...  
Keyword(s):  
Animal Model ◽  
Salivary Gland ◽  
Peripheral Nerve ◽  
Genome Sequence ◽  
Human Herpesvirus ◽  
Sequencing Analysis ◽  
Viral Loads ◽  
Salivary Gland Tissue ◽  
Gland Tissue ◽  
Relevant Animal Model

ABSTRACTHuman herpesvirus 6A (HHV-6A), HHV-6B, and HHV-7 are classified as roseoloviruses and are highly prevalent in the human population. Roseolovirus reactivation in an immunocompromised host can cause severe pathologies. While the pathogenic potential of HHV-7 is unclear, it can reactivate HHV-6 from latency and thus contributes to severe pathological conditions associated with HHV-6. Because of the ubiquitous nature of roseoloviruses, their roles in such interactions and the resulting pathological consequences have been difficult to study. Furthermore, the lack of a relevant animal model for HHV-7 infection has hindered a better understanding of its contribution to roseolovirus-associated diseases. Using next-generation sequencing analysis, we characterized the unique genome of an uncultured novel pigtailed macaque roseolovirus. Detailed genomic analysis revealed the presence of gene homologs to all 84 known HHV-7 open reading frames. Phylogenetic analysis confirmed that the virus is a macaque homolog of HHV-7, which we have provisionally namedMacaca nemestrinaherpesvirus 7 (MneHV7). Using high-throughput RNA sequencing, we observed that the salivary gland tissue samples from nine different macaques had distinct MneHV7 gene expression patterns and that the overall number of viral transcripts correlated with viral loads in parotid gland tissue and saliva. Immunohistochemistry staining confirmed that, like HHV-7, MneHV7 exhibits a natural tropism for salivary gland ductal cells. We also observed staining for MneHV7 in peripheral nerve ganglia present in salivary gland tissues, suggesting that HHV-7 may also have a tropism for the peripheral nervous system. Our data demonstrate that MneHV7-infected macaques represent a relevant animal model that may help clarify the causality between roseolovirus reactivation and diseases.IMPORTANCEHuman herpesvirus 6A (HHV-6A), HHV-6B, and HHV-7 are classified as roseoloviruses. We have recently discovered that pigtailed macaques are naturally infected with viral homologs of HHV-6 and HHV-7, which we provisionally named MneHV6 and MneHV7, respectively. In this study, we confirm that MneHV7 is genetically and biologically similar to its human counterpart, HHV-7. We determined the complete unique MneHV7 genome sequence and provide a comprehensive annotation of all genes. We also characterized viral transcription profiles in salivary glands from naturally infected macaques. We show that broad transcriptional activity across most of the viral genome is associated with high viral loads in infected parotid glands and that late viral protein expression is detected in salivary duct cells and peripheral nerve ganglia. Our study provides new insights into the natural behavior of an extremely prevalent virus and establishes a basis for subsequent investigations of the mechanisms that cause HHV-7 reactivation and associated disease.

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