CARVEDILOL, A NEW β-BLOCKER, VASODILATOR, and FREE RADICAL SCAVENGER, EXERTS PROTECTIVE EFFECTS IN RAT SPLANCHNIC ISCHEMIA, and REPERFUSION

Shock ◽  
1995 ◽  
Vol 3 (6) ◽  
pp. 13
Author(s):  
T. Christopher ◽  
B. Lopez ◽  
T. Yue ◽  
G. Feuerstein ◽  
R. Ruffolo
Keyword(s):  
Free Radical ◽  
Free Radical Scavenger ◽  
Radical Scavenger ◽  
Ischemia And Reperfusion ◽  
Protective Effects ◽  
Splanchnic Ischemia ◽  
Β Blocker

Proteomics of ischemia and reperfusion injuries in rabbit myocardium with and without intervention by an oxygen-free radical scavenger

PROTEOMICS ◽  
2006 ◽  
Vol 6 (23) ◽  
pp. 6221-6233 ◽  
Author(s):  
Melanie Y. White ◽  
Adrian S. Tchen ◽  
Hugh C. K. McCarron ◽  
Brett D. Hambly ◽  
Richmond W. Jeremy ◽  
...  
Keyword(s):  
Free Radical ◽  
Oxygen Free Radical ◽  
Free Radical Scavenger ◽  
Radical Scavenger ◽  
Ischemia And Reperfusion ◽  
Rabbit Myocardium ◽  
Oxygen Free Radical Scavenger

scholarly journals Antimutagenic and antirecombinagenic activities of noni fruit juice in somatic cells of Drosophila melanogaster

2013 ◽  
Vol 85 (2) ◽  
pp. 585-594 ◽  
Author(s):  
LEONARDO P. FRANCHI ◽  
NILZA N. GUIMARAES ◽  
LAISE R. DE ANDRADE ◽  
HELOISA H.R. DE ANDRADE ◽  
MAURICIO LEHMANN ◽  
...  
Keyword(s):  
Drosophila Melanogaster ◽  
Free Radical ◽  
Fruit Juice ◽  
Marked Decrease ◽  
Free Radical Scavenger ◽  
Morinda Citrifolia ◽  
Radical Scavenger ◽  
Protective Effects ◽  
Genotoxic Effects ◽  
Induced Mutant

Noni, a Hawaiian name for the fruit of Morinda citrifolia L., is a traditional medicinal plant from Polynesia widely used for the treatment of many diseases including arthritis, diabetes, asthma, hypertension and cancer. Here, a commercial noni juice (TNJ) was evaluated for its protective activities against the lesions induced by mitomycin C (MMC) and doxorrubicin (DXR) using the Somatic Mutation and Recombination Test (SMART) in Drosophila melanogaster. Three-day-old larvae, trans-heterozygous for two genetic markers (mwh and flr3 ), were co-treated with TNJ plus MMC or DXR. We have observed a reduction in genotoxic effects of MMC and DXR caused by the juice. TNJ provoked a marked decrease in all kinds of MMC- and DXR-induced mutant spots, mainly due to its antirecombinagenic activity. The TNJ protective effects were concentration-dependent, indicating a dose-response correlation, that can be attributed to a powerful antioxidant and/or free radical scavenger ability of TNJ.

scholarly journals The β-Blocker Carvedilol Prevented Ultraviolet-Mediated Damage of Murine Epidermal Cells and 3D Human Reconstructed Skin

2020 ◽  
Vol 21 (3) ◽  
pp. 798 ◽  
Author(s):  
Mengbing Chen ◽  
Sherry Liang ◽  
Ayaz Shahid ◽  
Bradley T. Andresen ◽  
Ying Huang
Keyword(s):  
Cell Death ◽  
Dna Repair ◽  
Antioxidant Property ◽  
Free Radical Scavenger ◽  
Radical Scavenger ◽  
Protective Effects ◽  
Ros Scavenging ◽  
Ki 67 ◽  
Β Blocker ◽  
P Cells

The β-blocker carvedilol prevents ultraviolet (UV)-induced skin cancer, but the mechanism is unknown. Since carvedilol possesses antioxidant activity, this study investigated whether carvedilol prevents oxidative photodamage of skin, a precursor event in skin carcinogenesis. The effects of carvedilol, metoprolol (a β-blocker without antioxidant property), and 4-hydroxycarbazole (4-OHC, a carvedilol synthesis intermediate and a free radical scavenger) were compared on UV- or H2O2-induced cell death and reactive oxygen species (ROS) production in murine epidermal JB6 P+ cells. Although carvedilol attenuated cell death, metoprolol and 4-OHC failed to show protective effects. As expected, increased cellular ROS induced by H2O2 or UV was abolished by carvedilol and 4-OHC, but not by metoprolol. Consistently, carvedilol attenuated the formation of UV-induced cyclobutane pyrimidine dimers (CPDs) and release of prostaglandin E2 in JB6 P+ cells. Carvedilol’s activity was further confirmed in full thickness 3D human reconstituted skin, where carvedilol attenuated UV-mediated epidermal thickening, the number of Ki-67 and p53 positive cells as well as CPD formation. Based on pathway-specific Polymerase Chain Reaction (PCR) Array analysis, carvedilol treatment in many cases normalized UV-induced expression changes in DNA repair genes. Thus, carvedilol’s photoprotective activity is not attributed to β-blockade or direct ROS-scavenging capacity, but likely via DNA repair regulation.

Enterochromaffin cells as the source of melatonin: key findings and functional relevance in mammals

2019 ◽  
Vol 2 (4) ◽  
pp. 61-82
Author(s):  
Palash K. Pal ◽  
Swaimanti Sarkar ◽  
Aindrila Chattopadhyay ◽  
Dunxian X Tan ◽  
Debasish Bandyopadhyay
Keyword(s):  
Oxidative Stress ◽  
Free Radical ◽  
Critical Role ◽  
Free Radical Scavenger ◽  
Radical Scavenger ◽  
Protective Effects ◽  
Gi Tract ◽  
Food Residue ◽  
Ec Cells ◽  
Functional Relevance

The enteroendocrine cells in gastrointestinal (GI) tract synthesize more than thirty hormones in mammals. Among these cells, the enterochromaffin (EC) cells are probably the most important one due to the fact that they produce melatonin. The rate-limiting enzymes for melatonin synthesis including arylalkylamine-N-acetyltransferase (AANAT, currently the SNAT) and hydroxyindole-O-methyltransferase (HIOMT, currently the ASMT) have been identified in EC cells and this has confirmed the local melatonin production in GI tract by these cells. EC cells play a critical role in regulation of gastrointestinal physiology, particularly, in protection of the GI tract from free radical attack and inflammatory reaction. GI tract is the major site exposed to the oxidative stress and inflammation because of the food residue metabolism and the presence of trillions of microbes including the pathological bacteria. Thus, it requires strong protection. Melatonin synthesized by the EC cells provides the onsite protection in GI tract since this molecule is the potent free radical scavenger and effective ant-inflammatory agent. In this review we summarize the available information regarding the structural and functional variability of the EC cells as well as their pathophysiological roles in the GI tract. The focus is given to the protective effects of melatonin produced by the EC cells on the oxidative stress, inflammation and microbiota balance in GI tract. 

Protective effects of the free radical scavenger edaravone on acute pancreatitis-associated lung injury

2010 ◽  
Vol 630 (1-3) ◽  
pp. 152-157 ◽  
Author(s):  
Tao Yang ◽  
Yan-Fei Mao ◽  
Shuang-Qing Liu ◽  
Jiong Hou ◽  
Zhi-Yang Cai ◽  
...  
Keyword(s):  
Acute Pancreatitis ◽  
Free Radical ◽  
Lung Injury ◽  
Free Radical Scavenger ◽  
Radical Scavenger ◽  
Protective Effects
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