SYNERGISTIC UP-REGULATION OF IκBα mRNA EXPRESSION IN A MURINE MACROPHAGE CELL LINE FOLLOWING EXPOSURE TO GLUCAN PHOSPHATE AND ENDOTOXIN

Shock ◽  
1997 ◽  
Vol 7 (Supplement) ◽  
pp. 92
Author(s):  
David Williams ◽  
Tuanzhu Ha ◽  
Chuanfu Li ◽  
Antje Müller ◽  
John Raptis ◽  
...  
2000 ◽  
Vol 28 (02) ◽  
pp. 217-226 ◽  
Author(s):  
Hiroshi Kawamata ◽  
Hiroshi Ochiai ◽  
Naoki Mantani ◽  
Katsutoshi Terasawa

We have investigated the effect of Juzen-taiho-to (TJ-48) on inducible NO synthase (iNOS) expression and nitric oxide (NO) production in RAW264.7 cells, a murine macrophage cell line. TJ-48-lipopolysaccharide (LPS) combination induced iNOS mRNA expression earlier, stronger and remained longer that paralleled but with a higher NO production compared to LPS stimulation. TJ-48 itself showed no inducible effect either no NO production or iNOS mRNA expression. This phenomenon could be considered to contribute, at least in part, to the beneficial effects of TJ-48 through the iNOS-mediated activation of biodefense mechanism.


2008 ◽  
Vol 123 (1-2) ◽  
pp. 159-165 ◽  
Author(s):  
Chise Suzuki ◽  
Hiromi Kimoto-Nira ◽  
Miho Kobayashi ◽  
Masaru Nomura ◽  
Keisuke Sasaki ◽  
...  

2010 ◽  
Vol 196 ◽  
pp. S201 ◽  
Author(s):  
R. Russo ◽  
G. Bianco ◽  
S. Marzocco ◽  
A. De Simone ◽  
G. Autore ◽  
...  

Endocrinology ◽  
1995 ◽  
Vol 136 (10) ◽  
pp. 4285-4292 ◽  
Author(s):  
J H Shin ◽  
A Kukita ◽  
K Ohki ◽  
T Katsuki ◽  
O Kohashi

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