CHARACTERIZATION OF FOCAL MULTIPLE SCLEROSIS LESIONS AND NORMAL APPEARING WHITE MATTER IN INTACT FIXED BRAINS BY EX VIVO MAGNETIZATION TRANSFER MEASURES: A PILOT STUDY.

2004 ◽  
Vol 52 ◽  
pp. S156
Author(s):  
R. T. Downey ◽  
M. S. Brown ◽  
J. H. Simon
Keyword(s):  
Multiple Sclerosis ◽  
White Matter ◽  
Pilot Study ◽  
Ex Vivo ◽  
Magnetization Transfer ◽  
Normal Appearing White Matter

scholarly journals Magnetization transfer and adiabatic T1ρ MRI reveal abnormalities in normal-appearing white matter of subjects with multiple sclerosis

2013 ◽  
Vol 20 (8) ◽  
pp. 1066-1073 ◽  
Author(s):  
Silvia Mangia ◽  
Adam F Carpenter ◽  
Andy E Tyan ◽  
Lynn E Eberly ◽  
Michael Garwood ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
White Matter ◽  
Magnetization Transfer ◽  
Magnetic Resonance Images ◽  
Relaxation Methods ◽  
Normal Appearing White Matter ◽  
Relaxation Parameters ◽  
Relapsing Remitting ◽  
Cortical Gray Matter ◽  
The Brain

Background: Diffuse abnormalities are known to occur within the brain tissue of multiple sclerosis (MS) patients that is “normal appearing” on T1-weighted and T2-weighted magnetic resonance images. Objectives: With the goal of exploring the sensitivity of novel MRI parameters to detect such abnormalities, we implemented an inversion-prepared magnetization transfer (MT) protocol and adiabatic T1ρ and T2ρ rotating frame relaxation methods. Methods: Nine relapsing–remitting MS patients and seven healthy controls were recruited. Relaxation parameters were measured in a single slice just above the lateral ventricles and approximately parallel to the AC-PC line. Results: The MT ratio of regions encompassing the normal-appearing white matter (NAWM) was different in MS patients as compared with controls ( p = 0.043); however, the T1 measured during off-resonance irradiation (T1sat) was substantially more sensitive than the MT ratio for detecting differences between groups ( p = 0.0006). Adiabatic T1ρ was significantly prolonged in the NAWM of MS patents as compared to controls (by 6%, p = 0.026), while no differences were found among groups for T2ρ. No differences among groups were observed in the cortical gray matter for any relaxation parameter. Conclusions: The results suggest degenerative processes occurring in the NAWM of MS, likely not accompanied by significant abnormalities in iron content.

A Magnetization Transfer Imaging Study of Normal-Appearing White Matter in Multiple Sclerosis

Neurology ◽  
1995 ◽  
Vol 45 (3) ◽  
pp. 478-482 ◽  
Author(s):  
M. Filippi ◽  
A. Campi ◽  
V. Dousset ◽  
C. Baratti ◽  
V. Martinelli ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
White Matter ◽  
Magnetization Transfer ◽  
Imaging Study ◽  
Magnetization Transfer Imaging ◽  
Normal Appearing White Matter

scholarly journals Magnetization transfer ratio measures in normal-appearing white matter show periventricular gradient abnormalities in multiple sclerosis

Brain ◽  
2015 ◽  
Vol 138 (5) ◽  
pp. 1239-1246 ◽  
Author(s):  
Zheng Liu ◽  
Matteo Pardini ◽  
Özgür Yaldizli ◽  
Varun Sethi ◽  
Nils Muhlert ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
White Matter ◽  
Magnetization Transfer ◽  
Magnetization Transfer Ratio ◽  
Transfer Ratio ◽  
Normal Appearing White Matter

scholarly journals The Prognostic Value of White-Matter Selective Double Inversion Recovery MRI Sequence in Multiple Sclerosis: An Exploratory Study

Diagnostics ◽  
2021 ◽  
Vol 11 (4) ◽  
pp. 686
Author(s):  
Francesco Crescenzo ◽  
Damiano Marastoni ◽  
Anna Isabella Pisani ◽  
Agnese Tamanti ◽  
Caterina Dapor ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
White Matter ◽  
Magnetization Transfer ◽  
Inversion Recovery ◽  
Double Inversion Recovery ◽  
Magnetization Transfer Ratio ◽  
Tissue Properties ◽  
Relapsing Remitting ◽  
3.0 T

Using a white-matter selective double inversion recovery sequence (WM-DIR) that suppresses both grey matter (GM) and cerebrospinal fluid (CSF) signals, some white matter (WM) lesions appear surrounded by a dark rim. These dark rim lesions (DRLs) seem to be specific for multiple sclerosis (MS). They could be of great usefulness in clinical practice, proving to increase the MRI diagnostic criteria specificity. The aims of this study are the identification of DRLs on 1.5 T MRI, the exploration of the relationship between DRLs and disease course, the characterization of DRLs with respect to perilesional normal-appearing WM using magnetization transfer imaging, and the investigation of possible differences in the underlying tissue properties by assessing WM-DIR images obtained at 3.0 T MRI. DRLs are frequent in primary progressive MS (PPMS) patients. Amongst relapsing-remitting MS (RRMS) patients, DRLs are associated with a high risk of the disease worsening and secondary progressive MS (SPMS) conversion after 15 years. The mean magnetization transfer ratio (MTR) of DRLs is significantly different from the lesion without the dark rim, suggesting that DRLs correspond to more destructive lesions.

Multiple Sclerosis: Magnetization Transfer Histogram Analysis of Segmented Normal-appearing White Matter

Radiology ◽  
2000 ◽  
Vol 216 (2) ◽  
pp. 351-355 ◽  
Author(s):  
Isabelle Catalaa ◽  
Robert I. Grossman ◽  
Dennis L. Kolson ◽  
Jayaram K. Udupa ◽  
Laszlo G. Nyul ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
White Matter ◽  
Magnetization Transfer ◽  
Histogram Analysis ◽  
Normal Appearing White Matter
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