Demographic and Clinical Factors Associated with Development of Brimonidine Tartrate 0.2%-Induced Ocular Allergy

2004 ◽  
Vol 13 (2) ◽  
pp. 163-167 ◽  
Author(s):  
Gianluca Manni ◽  
Marco Centofanti ◽  
Marta Sacchetti ◽  
Francesco Oddone ◽  
Stefano Bonini ◽  
...  
2007 ◽  
Vol 17 (5_suppl) ◽  
pp. 22-23 ◽  
Author(s):  
G. Manni

Purpose. Ocular allergy induced by brimonidine tartrate 0.2% is a common adverse event that is associated with poor compliance and therefore treatment failure. The authors investigated the demographic and clinical characteristics associated with development of this allergy. Methods. In total, 133 patients with ocular hypertension or open angle glaucoma and treated with brimonidine tartrate 0.2% were retrospectively divided into two groups: allergic and nonallergic to brimonidine tartrate 0.2%. Demographic, local, and systemic ocular variables were compared in the two groups. Results. Altogether, 13.5% of patients (18 of 133) developed brimonidine ocular allergy, generally within 2 weeks of beginning treatment (mean time 14.8±17.9 days). Compared with the nonallergic group, the allergic group was significantly more likely to have a history of ocular allergy to eyedrops (p=0.048) and to topical beta blockers (p=0.019). Moreover, the allergic group showed decreased tear film production (p=0.044). Conclusions. Patients with a history of eyedrop allergy or with reduced tear film production are more likely to develop brimonidine-associated allergy. Brimonidine may therefore not be suitable for patients with a history of allergy.


Author(s):  
Alessandra Bandera ◽  
Alessandro Nobili ◽  
Mauro Tettamanti ◽  
Sergio Harari ◽  
Silvano Bosari ◽  
...  

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Camilla Pegram ◽  
Carol Gray ◽  
Rowena M. A. Packer ◽  
Ysabelle Richards ◽  
David B. Church ◽  
...  

AbstractThe loss of a pet can be particularly distressing for owners, whether the method of death is euthanasia or is unassisted. Using primary-care clinical data, this study aimed to report the demographic and clinical factors associated with euthanasia, relative to unassisted death, in dogs. Method of death (euthanasia or unassisted) and clinical cause of death were extracted from a random sample of 29,865 dogs within the VetCompass Programme from a sampling frame of 905,544 dogs under UK veterinary care in 2016. Multivariable logistic regression modelling was used to evaluate associations between risk factors and method of death. Of the confirmed deaths, 26,676 (89.3%) were euthanased and 2,487 (8.3%) died unassisted. After accounting for confounding factors, 6 grouped-level disorders had higher odds in euthanased dogs (than dogs that died unassisted), using neoplasia as the baseline. The disorders with greatest odds included: poor quality of life (OR 16.28), undesirable behaviour (OR 11.36) and spinal cord disorder (OR 6.00). Breed, larger bodyweight and increasing age were additional risk factors for euthanasia. The results highlight that a large majority of owners will face euthanasia decisions and these findings can support veterinarians and owners to better prepare for such an eventuality.


2021 ◽  
Vol 224 (2) ◽  
pp. S101
Author(s):  
Danielle M. Panelli ◽  
Stephanie A. Leonard ◽  
Noor Joudi ◽  
Anna Girsen ◽  
Amy Judy ◽  
...  

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