Relationship quality: effects on ambulatory blood pressure and negative affect in a biracial sample of men and women

Abstract Objectives To investigate the short-term impact of supplementation with a combination of polyphenols extracts and L-citrulline on ambulatory blood pressure (BP), vascular function and inflammation in pre-hypertensive individuals. Methods In a randomized double-blind parallel trial, men and women with pre-hypertension were subjected to 6-wk supplementation with 764 mg/day of polyphenols extracts from cranberries and grape seeds and 2 g/day of L-citrulline (n = 35) or with placebo (cellulose, n = 34). The primary outcome of this study was the change in 24-hour ambulatory BP, which was monitored every 20 minutes during daytime and every 60 minutes during nighttime both at baseline and at week 6 post-intervention. Secondary outcomes included glycation products, a proxy of vascular function measured by a sensitive cutaneous optical method as well as blood lipids and CRP. Changes in study outcomes were analyzed using mixed models in SAS. The potential impact of sex and obesity status on the response to supplementation was also considered in the analysis. Results Supplementation with the polyphenol extracts and L-citrulline had no impact on mean ambulatory systolic (P > 0.10) and diastolic (P > 0.50) BP. However, the ambulatory systolic BP response was different in men and women (Pinteraction < 0.01 for 24-h BP and daytime BP) but not the diastolic BP. The ambulatory systolic BP after supplementation compared with placebo was significantly reduced in women (24-h BP −3.9 mmHg, P = 0.01; daytime BP −4.4 mmHg, P = 0.005) but not in men (24-h BP + 1.8 mmHg, P = 0.48; daytime BP + 1.8 mmHg, P = 0.55). A trend for a reduction in glycation products was observed after polyphenol and L-citrulline supplementation compared to placebo (P = 0.07) but there was no difference in the concentrations of blood lipids (P > 0.20 for all) or CRP (P = 0.36) between treatments. Conclusions Supplementation with polyphenol extracts/L-citrulline for 6 weeks may reduce ambulatory systolic BP in pre-hypertensive women, but not in men. The present data also indicate that the polyphenols extract/L-citrulline supplement has no impact on blood lipids and CRP in pre-hypertensive men and women. Funding Sources The study was funded by Atrium Innovations. Supplement of polyphenol extracts and L-citrulline as well as placebo were supplied by Pure Encapsulations.

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Twenty-four-hour ambulatory blood pressure in men and women aged 17 to 80 years: the Allied Irish Bank Study

Journal of Hypertension ◽

10.1097/00004872-199104000-00007 ◽

1991 ◽

Vol 9 (4) ◽

pp. 355-360 ◽

Cited By ~ 160

Author(s):

Eoin O??Brien ◽

Joan Murphy ◽

Anne Tyndall ◽

Neil Atkins ◽

F??insia Mee ◽

...

Keyword(s):

Blood Pressure ◽

Ambulatory Blood Pressure ◽

Men And Women

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High Job Strain and Ambulatory Blood Pressure in Middle-Aged Men and Women From the Belgian Job Stress Study

Journal of Occupational and Environmental Medicine ◽

10.1097/jom.0b013e31803b94e2 ◽

2007 ◽

Vol 49 (4) ◽

pp. 360-367 ◽

Cited By ~ 45

Author(s):

Els Clays ◽

Francoise Leynen ◽

Dirk De Bacquer ◽

Marcel Kornitzer ◽

France Kittel ◽

...

Keyword(s):

Blood Pressure ◽

Job Stress ◽

Ambulatory Blood Pressure ◽

Job Strain ◽

Middle Aged ◽

Men And Women ◽

Stress Study

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The Effects of Ambulatory Blood Pressure Monitoring on Sleep Quality in Men and Women With Hypertension: Dipper vs. Nondipper and Race Differences

American Journal of Hypertension ◽

10.1093/ajh/hpy138 ◽

2018 ◽

Vol 32 (1) ◽

pp. 54-60 ◽

Cited By ~ 1

Author(s):

Andrew Sherwood ◽

LaBarron K Hill ◽

James A Blumenthal ◽

Alan L Hinderliter

Keyword(s):

Blood Pressure ◽

Sleep Quality ◽

Ambulatory Blood Pressure Monitoring ◽

Ambulatory Blood Pressure ◽

Blood Pressure Monitoring ◽

Race Differences ◽

Pressure Monitoring ◽

Men And Women

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Walking Workstation Use Reduces Ambulatory Blood Pressure in Adults with Prehypertension

Journal of Physical Activity and Health ◽

10.1123/jpah.2013-0487 ◽

2015 ◽

Vol 12 (s1) ◽

pp. S119-S127 ◽

Cited By ~ 12

Author(s):

Zachary S. Zeigler ◽

Pamela D. Swan ◽

Dharini M. Bhammar ◽

Glenn A. Gaesser

Keyword(s):

Physical Activity ◽

Blood Pressure ◽

Light Intensity ◽

Ambulatory Blood Pressure ◽

Acute Effect ◽

Men And Women ◽

Low Intensity ◽

Intensity Physical Activity ◽

Pm 10

Background:The acute effect of low-intensity walking on blood pressure (BP) is unclear.Purpose:To determine if the acute use of a walking workstation reduces ambulatory blood pressure (ABP) in prehypertensive men and women.Methods:Ten prehypertensive adults participated in a randomized, cross-over study that included a control workday and a walking workstation workday. ABP was measured for 7 hour during the workday and for 6 hour after work.Results:Both systolic BP (SBP) (134 ± 14 vs. 137 ± 16 mmHg; P = .027) and diastolic BP (DBP) (79 ± 10 vs. 82 ± 12 mmHg; P = .001) were lower on the walking workstation day. Postwork hours (4:00 PM–10:00 PM), SBP (129 ± 13 vs. 133 ± 14 mmHg; P = .008), and DBP (74 ± 11 vs. 78 ± 13 mmHg; P = .001) were also lower on the walking workstation day. DBP load was significantly lower during the walking workstation day, with only 14% of the readings above 90 mmHg compared with 22% of the control day readings (P = .037).Conclusion:Accumulation of very-light-intensity physical activity (~2 METs) over the course of a single work day using a walking workstation may reduce BP burden in prehypertensive individuals.

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Effects of isometric leg training on ambulatory blood pressure and morning blood pressure surge in young normotensive men and women

Scientific Reports ◽

10.1038/s41598-021-04092-z ◽

2022 ◽

Vol 12 (1) ◽

Author(s):

Anthony W. Baross ◽

Robert D. Brook ◽

Anthony D. Kay ◽

Reuben Howden ◽

Ebony C. Gaillard ◽

...

Keyword(s):

Blood Pressure ◽

Ambulatory Blood Pressure ◽

Disease Risk ◽

Cardiovascular Disease Risk ◽

Maximum Voluntary Contraction ◽

Voluntary Contraction ◽

Men And Women ◽

Morning Blood Pressure Surge ◽

Morning Blood Pressure ◽

Pressure Surge

AbstractDespite the reported association between diurnal variations in ambulatory blood pressure (BP) and elevated cardiovascular disease risk, little is known regarding the effects of isometric resistance training (IRT), a practical BP-lowering intervention, on ambulatory BP and morning BP surge (MBPS). Thus, we investigated whether (i) IRT causes reductions in ambulatory BP and MBPS, in young normotensives, and (ii) if there are any sex differences in these changes. Twenty normotensive individuals (mean 24-h SBP = 121 ± 7, DBP = 67 ± 6 mmHg) undertook 10-weeks of bilateral-leg IRT (4 × 2-min/2-min rest, at 20% maximum voluntary contraction (MVC) 3 days/week). Ambulatory BP and MBPS (mean systolic BP (SBP) 2 h after waking minus the lowest sleeping 1 h mean SBP) was measures pre- and post-training. There were significant reductions in 24-h ambulatory SBP in men (− 4 ± 2 mmHg, P = 0.0001) and women (− 4 ± 2 mmHg, P = 0.0001) following IRT. Significant reductions were also observed in MBPS (− 6 ± 8 mmHg, p = 0.044; − 6 ± 7 mmHg, P = 0.019), yet there were no significant differences between men and women in these changes, and 24-h ambulatory diastolic BP remained unchanged. Furthermore, a significant correlation was identified between the magnitude of the change in MBPS and the magnitude of changes in the mean 2-h SBP after waking for both men and women (men, r = 0.89, P = 0.001; women, r = 0.74, P = 0.014). These findings add further support to the idea that IRT, as practical lifestyle intervention, is effective in significantly lowering ambulatory SBP and MBPS and might reduce the incidence of adverse cardiovascular events that often occur in the morning.

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