scholarly journals PF267 RISK ASSESSMENT OF ANTHRACYCLINE CARDIOTOXICITY IN PATIENTS WITH ACUTE LEUKEMIA AND CONCOMITANT ISCHEMIC HEART DISEASE

HemaSphere ◽  
2019 ◽  
Vol 3 (S1) ◽  
pp. 85
Author(s):  
T. Lymanets ◽  
I. Skrypnyk ◽  
G. Maslova ◽  
I. Gusachenko
Keyword(s):  
Risk Assessment ◽  
Heart Disease ◽  
Acute Leukemia ◽  
Ischemic Heart Disease ◽  
Ischemic Heart ◽  
Anthracycline Cardiotoxicity

scholarly journals Opportunistic Assessment of Ischemic Heart Disease Risk Using Abdominopelvic Computed Tomography and Medical Record Data: a Multimodal Explainable Artificial Intelligence Approach

2021 ◽  
Author(s):  
Juan M Zambrano Chaves ◽  
Akshay S Chaudhari ◽  
Andrew L Wentland ◽  
Arjun D Desai ◽  
Imon Banerjee ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Risk Assessment ◽  
Heart Disease ◽  
Ischemic Heart Disease ◽  
Medical Record ◽  
Disease Risk ◽  
Tissue Level ◽  
Ischemic Heart ◽  
Risk Scores ◽  
Imaging Biomarkers

AbstractCurrent risk scores for predicting ischemic heart disease (IHD) risk—the leading cause of global mortality—have limited efficacy. While body composition (BC) imaging biomarkers derived from abdominopelvic computed tomography (CT) correlate with IHD risk, they are impractical to measure manually. Here, in a retrospective cohort of 8,197 contrast-enhanced abdominopelvic CT examinations undergoing up to 5 years of follow-up, we developed improved multimodal opportunistic risk assessment models for IHD by automatically extracting BC features from abdominal CT images and integrating these with features from each patient’s electronic medical record (EMR). Our predictive methods match and, in some cases, outperform clinical risk scores currently used in IHD risk assessment. We provide clinical interpretability of our model using a new method of determining tissue-level contributions from CT along with weightings of EMR features contributing to IHD risk. We conclude that such a multimodal approach, which automatically integrates BC biomarkers and EMR data can enhance IHD risk assessment and aid primary prevention efforts for IHD.

scholarly journals The contribution of major depression to the global burden of ischemic heart disease: a comparative risk assessment

BMC Medicine ◽  
2013 ◽  
Vol 11 (1) ◽  
Author(s):  
Fiona J Charlson ◽  
Andrew E Moran ◽  
Greg Freedman ◽  
Rosana E Norman ◽  
Nicolas JC Stapelberg ◽  
...  
Keyword(s):  
Risk Assessment ◽  
Heart Disease ◽  
Major Depression ◽  
Ischemic Heart Disease ◽  
Ischemic Heart ◽  
Global Burden ◽  
Comparative Risk Assessment ◽  
Comparative Risk
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