AMR Series Unilateral (Localized) Renal Cystic Disease

2005 ◽  
Vol 12 (4) ◽  
pp. 227-232 ◽  
Author(s):  
Michele Bisceglia ◽  
Giuseppe Cret??
Keyword(s):  
Cystic Disease ◽  
Renal Cystic Disease

Renal cystic disease

1999 ◽  
Vol 11 (2) ◽  
pp. 141-151 ◽  
Author(s):  
Friedhelm Hildebrandt
Keyword(s):  
Cystic Disease ◽  
Renal Cystic Disease

scholarly journals Tissue-Resident Macrophages Promote Renal Cystic Disease

2019 ◽  
Vol 30 (10) ◽  
pp. 1841-1856 ◽  
Author(s):  
Kurt A. Zimmerman ◽  
Cheng J. Song ◽  
Zhang Li ◽  
Jeremie M. Lever ◽  
David K. Crossman ◽  
...  
Keyword(s):  
Renal Injury ◽  
Primary Cilia ◽  
Kinase Inhibitor ◽  
Renal Cyst ◽  
Cyst Formation ◽  
Mutant Mice ◽  
Cystic Disease ◽  
Renal Cystic Disease ◽  
Resident Macrophage ◽  
Membrane Bound

BackgroundMutations affecting cilia proteins have an established role in renal cyst formation. In mice, the rate of cystogenesis is influenced by the age at which cilia dysfunction occurs and whether the kidney has been injured. Disruption of cilia function before postnatal day 12–14 results in rapid cyst formation; however, cyst formation is slower when cilia dysfunction is induced after postnatal day 14. Rapid cyst formation can also be induced in conditional adult cilia mutant mice by introducing renal injury. Previous studies indicate that macrophages are involved in cyst formation, however the specific role and type of macrophages responsible has not been clarified.MethodsWe analyzed resident macrophage number and subtypes during postnatal renal maturation and after renal injury in control and conditional Ift88 cilia mutant mice. We also used a pharmacological inhibitor of resident macrophage proliferation and accumulation to determine the importance of these cells during rapid cyst formation.ResultsOur data show that renal resident macrophages undergo a phenotypic switch from R2b (CD11clo) to R2a (CD11chi) during postnatal renal maturation. The timing of this switch correlates with the period in which cyst formation transitions from rapid to slow following induction of cilia dysfunction. Renal injury induces the reaccumulation of juvenile-like R2b resident macrophages in cilia mutant mice and restores rapid cystogenesis. Loss of primary cilia in injured conditional Ift88 mice results in enhanced epithelial production of membrane-bound CSF1, a cytokine that promotes resident macrophage proliferation. Inhibiting CSF1/CSF1-receptor signaling with a CSF1R kinase inhibitor reduces resident macrophage proliferation, R2b resident macrophage accumulation, and renal cyst formation in two mouse models of cystic disease.ConclusionsThese data uncover an important pathogenic role for resident macrophages during rapid cyst progression.

scholarly journals Spontaneous Hemorrhage in Acquired Renal Cystic Disease

2010 ◽  
Vol 21 (1) ◽  
pp. 58-62
Author(s):  
Fee-Le Chen ◽  
Yuan-Lung Yang ◽  
Pi-Jen Hong
Keyword(s):  
Cystic Disease ◽  
Renal Cystic Disease ◽  
Spontaneous Hemorrhage ◽  
Acquired Renal Cystic Disease

Miscellaneous urological diseases of the kidney

2013 ◽  
pp. 395-426
Author(s):  
John Reynard ◽  
Simon Brewster ◽  
Suzanne Biers
Keyword(s):  
Vesicoureteric Reflux ◽  
Horseshoe Kidney ◽  
Renal Cysts ◽  
Cystic Disease ◽  
Ectopic Kidney ◽  
Medullary Sponge Kidney ◽  
Renal Cystic Disease ◽  
Calyceal Diverticulum ◽  
Autosomal Dominant Polycystic Kidney ◽  
Urological Diseases

Simple and complex renal cysts 396 Calyceal diverticulum 399 Medullary sponge kidney (MSK) 400 Acquired renal cystic disease (ARCD) 402 Autosomal dominant polycystic kidney disease (ADPKD) 404 Vesicoureteric reflux in adults 408 Pelviureteric junction obstruction in adults 412 Anomalies of renal fusion and ascent: horseshoe kidney, ectopic kidney ...

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