A Novel Perfluoroelastomer Seeded with Adipose-Derived Stem Cells for Soft-Tissue Repair

Wound management and soft-tissue repair can vary depending on the location. The head and neck, chest and back, arm and forearm, hand, abdomen, gluteal area and perineum, thigh, knee, lower leg, and foot all have different local options and preferred free flaps to use for reconstruction. Secondary reconstruction requires a detailed analysis of all aspects of the wound including any scars, soft tissue and/or skin deficits, functional defects, contour defects, complex or composite defects, and/or unstable previous wound coverage. Careful monitoring of both the patient and reconstruction is necessary in the postoperative period to ensure long-term success. This review contains 2 figures and 17 references. Key Words: free tissue transfer, pedicle flaps, soft-tissue coverage, wound closure, wound healing, wound management, wound reconstruction, tissue flaps

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Shape-memory Polymers for Orthopaedic Soft-Tissue Repair

Techniques in Orthopaedics ◽

10.1097/bto.0000000000000247 ◽

2017 ◽

Vol 32 (3) ◽

pp. 141-148 ◽

Cited By ~ 1

Author(s):

Kathryn E. Smith ◽

Mateo Garcia ◽

Kenneth M. Dupont ◽

Geoffrey B. Higgs ◽

Ken Gall ◽

...

Keyword(s):

Soft Tissue ◽

Shape Memory ◽

Tissue Repair ◽

Shape Memory Polymers ◽

Soft Tissue Repair

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Ultrafine fibrous gelatin scaffolds with deep cell infiltration mimicking 3D ECMs for soft tissue repair

Journal of Materials Science Materials in Medicine ◽

10.1007/s10856-014-5208-2 ◽

2014 ◽

Vol 25 (7) ◽

pp. 1789-1800 ◽

Cited By ~ 14

Author(s):

Qiuran Jiang ◽

Helan Xu ◽

Shaobo Cai ◽

Yiqi Yang

Keyword(s):

Soft Tissue ◽

Tissue Repair ◽

Cell Infiltration ◽

Soft Tissue Repair

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Porous Cellulose-Collagen Scaffolds For Soft Tissue Regeneration: Influence of Cellulose Derivatives On Mechanical Properties And Compatibility With Adipose-Derived Stem Cells.

10.21203/rs.3.rs-1187939/v1 ◽

2022 ◽

Author(s):

Katarína Kacvinská ◽

Martina Trávničková ◽

Lucy Vojtová ◽

Petr Poláček ◽

Jana Dorazilová ◽

...

Keyword(s):

Mechanical Properties ◽

Tissue Engineering ◽

Stem Cells ◽

Cell Adhesion ◽

Soft Tissue ◽

Vascular Tissue ◽

Biological Properties ◽

Cellulose Derivatives ◽

Adipose Derived Stem Cells ◽

Soft Tissue Regeneration

Abstract This study deals with cellulose derivatives in relation to the collagen fibrils in composite collagen-cellulose scaffolds for soft tissue engineering. Two types of cellulose, i.e., oxidized cellulose (OC) and carboxymethyl cellulose (CMC), were blended with collagen (Col) to enhance its elasticity, stability and sorptive biological properties, e.g. hemostatic and antibacterial features. The addition of OC supported the resistivity of the Col fibrils in a dry environment, while in a moist environment OC caused a radical drop. The addition of CMC reduced the mechanical strength of the Col fibrils in both environments. The elongation of the Col fibrils was increased by both types of cellulose derivatives in both environments, which is closely related to tissue like behaviour. In these various mechanical environments, the ability of human adipose-derived stem cells (hADSCs) to adhere and proliferate was significantly greater in the Col and Col/OC scaffolds than in the Col/CMC scaffold. This is explained by deficient mechanical support and loss of stiffness due to the high swelling capacity of CMC. Although Col/OC and Col/CMC acted differently in terms of mechanical properties, both materials were observed to be cytocompatible, with varying degrees of further support for cell adhesion and proliferation. While Col/OC can serve as a scaffolding material for vascular tissue engineering and for skin tissue engineering, Col/CMC seems to be more suitable for moist wound healing, e.g. as a mucoadhesive gel for exudate removal, since there was almost no cell adhesion.

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