scholarly journals High Urinary Excretion of Kidney Injury Molecule-1 Is an Independent Predictor of Graft Loss in Renal Transplant Recipients

2007 ◽  
Vol 84 (12) ◽  
pp. 1625-1630 ◽  
Author(s):  
Mirjan M. van Timmeren ◽  
Vishal S. Vaidya ◽  
Rutger M. van Ree ◽  
Leendert H. Oterdoom ◽  
Aiko P. J. de Vries ◽  
...  
Keyword(s):  
Renal Transplant ◽  
Urinary Excretion ◽  
Independent Predictor ◽  
Graft Loss ◽  
Kidney Injury ◽  
Renal Transplant Recipients ◽  
Transplant Recipients ◽  
High Urinary Excretion ◽  
Kidney Injury Molecule 1

Urinary Excretion of Kidney Injury Molecule -1 in Renal Transplant Recipients

2012 ◽  
Vol 94 (10S) ◽  
pp. 1166
Author(s):  
S. Kesiraju ◽  
P. Paritala ◽  
C. Uma Maheswara Rao ◽  
A. S. Murthy ◽  
V. S. Reddy ◽  
...  
Keyword(s):  
Renal Transplant ◽  
Urinary Excretion ◽  
Kidney Injury ◽  
Renal Transplant Recipients ◽  
Transplant Recipients ◽  
Kidney Injury Molecule 1

Skin-Autofluorescence Is an Independent Predictor of Graft Loss in Renal Transplant Recipients

2009 ◽  
Vol 87 (7) ◽  
pp. 1069-1077 ◽  
Author(s):  
Jasper W. L. Hartog ◽  
Sascha Gross ◽  
Leendert H. Oterdoom ◽  
Rutger M. van Ree ◽  
Aiko P. J. de Vries ◽  
...  
Keyword(s):  
Renal Transplant ◽  
Independent Predictor ◽  
Graft Loss ◽  
Renal Transplant Recipients ◽  
Skin Autofluorescence ◽  
Transplant Recipients

scholarly journals Assessment of renal function and acute rejection using Cystatin C and kidney injury Molecule-1 in renal transplant recipients

2018 ◽  
Vol 12 (1) ◽  
pp. 53
Author(s):  
Sailaja Kesiraju ◽  
LakshmiKiran Chelluri ◽  
Sumanlatha Gaddam ◽  
VijayaLakshmi Valluri ◽  
UmaMaheswara Rao Ch ◽  
...  
Keyword(s):  
Renal Function ◽  
Renal Transplant ◽  
Acute Rejection ◽  
Cystatin C ◽  
Kidney Injury ◽  
Renal Transplant Recipients ◽  
Transplant Recipients ◽  
Kidney Injury Molecule 1

scholarly journals FP247The urinary microbiome during acute kidney injury in renal transplant recipients versus non-transplant recipients

2019 ◽  
Vol 34 (Supplement_1) ◽  
Author(s):  
Daniela Knafl ◽  
Wolfgang Winnicki ◽  
Alexander Zimprich ◽  
Christoph Hotzy ◽  
Wolfgang Barousch ◽  
...  
Keyword(s):  
Acute Kidney Injury ◽  
Renal Transplant ◽  
Kidney Injury ◽  
Renal Transplant Recipients ◽  
Transplant Recipients ◽  
Urinary Microbiome

Human BK Polyomavirus Nephropathy (BKVN) In Non- Kidney-Transplant Patients

2020 ◽  
Vol 154 (Supplement_1) ◽  
pp. S118-S118
Author(s):  
Y Chen Wongworawat ◽  
C Zuppan
Keyword(s):  
Renal Transplant ◽  
Kidney Transplant ◽  
Graft Loss ◽  
Renal Transplant Recipients ◽  
Transplant Recipients ◽  
Transplant Patients ◽  
Bk Polyomavirus ◽  
Pathologic Features ◽  
Renal Biopsies ◽  
Renal Transplant Patients

Abstract Introduction/Objective Human BK polyomavirus nephropathy (BKVN) occurs in up to 10% of renal transplant recipients, and can result in graft loss. Transplant biopsy is the gold standard to diagnose BKVN, and SV40 immunohistochemical (IHC) staining is helpful in confirming the diagnosis. BKVN is uncommon outside the setting of renal transplantation. To understand more about its occurrence in other contexts, we reviewed our renal biopsies files for cases of BKVN. Methods Our renal biopsy files for the past 20 years were reviewed for all cases with a diagnosis of BKVN or polyoma virus infection, and the clinical characteristics of the affected patients noted. Results Evidence of BKVN was found in 44 renal biopsies, of which 39 (86%) were renal transplant patients. Of the remaining five patients (14%), two had undergone heart transplantation, one lung transplantation, one was undergoing chemotherapy for acute lymphoblastic leukemia, and one patient had active HIV infection. All patients had elevated serum creatinine, and four out of five patients had documented BK viremia. Four of the five biopsies showed typical tubular injury with viral nuclear cytopathic changes (inclusions). In the lung transplant patient, the biopsy showed advanced chronic tubulointerstitial injury without distinct viral inclusions, but SV40 staining confirmed the presence of BK virus antigen. Conclusion The BKVN is distinctly uncommon outside the context of kidney transplantation. In our series, 14% of patients with BKVN were not kidney transplant recipients, but all were immune compromised in some fashion. The pathologic features of BKVN appear similar, regardless of whether the host is a renal transplant recipient or not. Although uncommon, it is important to consider the possibility of BKVN in non-renal transplant patients with persistent or progressive renal dysfunction.

MO998EARLY VERSUS LATE ACUTE GRAFT PYELONEPHRITIS: A RETROSPECTIVE ANALYSIS OF GRAFT AND PATIENT OUTCOMES

2021 ◽  
Vol 36 (Supplement_1) ◽  
Author(s):  
Anupma Kaul ◽  
Thomas Mathews
Keyword(s):  
Renal Transplant ◽  
Graft Survival ◽  
Patient Survival ◽  
Univariate Analysis ◽  
Graft Loss ◽  
Renal Transplant Recipients ◽  
Transplant Recipients ◽  
Kaplan Meier ◽  
Baseline Characteristics ◽  
Acute Graft

Abstract Background and Aims Acute graft pyelonephritis(AGPN) is thought to affect graft and patient survival among renal transplant recipients. Our objective was to compare these outcomes in those having early AGPN(<6 months from transplant) versus those having late AGPN(>6months from transplant) Method This retrospective study analyzed 150 patients who had AGPN over a period of 8 years from 2005 to 2013. They were divided into early AGPN group and late AGPN group. Their baseline characteristics were compared. Predictors of graft loss and mortality were compared using logistic regression analysis. Graft survival and patient survival were analyzed using Kaplan-Meyer survival plots Results A total of 150 patients with AGPN were analyzed. Of these 55.3% (n=83) had early AGPN and 44.7% (n=67) had late AGPN. These two groups were comparable regarding baseline characteristics and immunosuppression. In early AGPN group, 13.3% (n=11) patients had CMV disease during follow up compared to 3% (n=2) in late AGPN group(p<0.05). In the early AGPN group, 26.5% (n=22) had prolonged Foley’s catheterization (>5days) following transplant surgery compared to 7.5% (n=5) in late AGPN group (p<0.05). In the early AGPN group, 38.6% (n=32) had prolonged DJ stent in-situ (>2weeks) following transplant surgery compared to 19.4% (n=13) in the late AGPN group (p<0.05). Recurrent GPN was more common in the late AGPN group than the early AGPN group - 35.8% (n=24) versus 18.1% (n=15). Predictors for graft loss were assessed in patients with AGPN and the presence of renal abscess was predictive of graft loss in univariate analysis (HR-6.129, 95% CI 1.776–21.154, p-0.004). There were no significant predictors of mortality in univariate analysis. Kaplan Meier survival analysis showed decreased death censored graft survival in the early AGPN group (p-0.035). There was no Conclusion Occurrence of early AGPN had a significant impact on long term graft survival in renal transplant recipients with no significant effect on patient survival. This study underlines the paramount importance of the prevention of UTIs in renal transplant recipients.

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